Integrated Microfabricated Biodevices: Advanced Technologies for Genomics, Drug Discovery, Bioanalysis, and Clinical Diagnostics, 1st Edition (Hardback) book cover

Integrated Microfabricated Biodevices

Advanced Technologies for Genomics, Drug Discovery, Bioanalysis, and Clinical Diagnostics, 1st Edition

Edited by Michael J. Heller, Andras Guttman

CRC Press

456 pages

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Hardback: 9780824706067
pub: 2002-01-03
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Description

This book discusses the new generation of integrated microfabricated devices, including DNA chips, Lab-on-a-Chip, microcapillary electrophoresis systems, biosensors, and microanalytical systems. It traces their development with the established and evolving technologies such as microlithography, micromachining, microelectromechanical systems, microfluids, and nanotechnology.

Table of Contents

Towards integrated electrophoretic microdevice for clinical diagnostics; creating a lab-on-a-chip with microfluidic technologies; Short Tandem Repeat (STR) analysis on microfabricated electrophoretic devices; basic sample preparation - DNA separation and purification; multiplex integrated online sample preparation for DNA sequencing and genetic typing; interfacing capillaries to microseparation devices for sample introduction; electric field meditated separation of DNA fragments on planar gel microchips; development of battery powered, portable instrumentation for rapid PCR analysis; practical aspects of sheath flow fraction collection in CE; microelectric array systems for DNA diagnostic and pharmacogenomic applications; the flowthru chip - a miniature, three-dimensional biochip platform; DNA arrays on plastic devices; microfluidic devices fabricated by polymer hot embossing; microfabricated reactor technology; approaches toward miniaturization of high throughput screening of chemical libraries; integrated microsystems in clinical chemistry - constraints and consequences.

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
SCI045000
SCIENCE / Life Sciences / Biology / Microbiology