This publication is a collection of essays on the biology of intracellular parasitisms where both bacterial and protozoan parasites are discussed. The juxtaposition of authors representing fields of research emphasizes the many common problems facing intracellular parasites and the hosts that harbor them. In addition, numerous illustrations of how different parasites and host attempt to solve these problems in different ways are provided. The book includes one or more chapters on Bdellovibrio, Chlamydia, Rickettsia, Coxiella, Legionella, Shigellae, Mycobacterium, Microsporidium, Plasmodium, and Toxoplasma. The authors frequently speculate and generalize on the subject matter discussed.
Table of Contents
Polyphyletic Origin of Bacterial Parasites. Cell Envelope Modifications Accompanying Intracellular Growth of Bdellovibrie bacteriovorus. The Host Cell Host Immune Responses and the Intracellular Growth of Chlamydia. Antigenic Variation of Chlamydia Trachomatis. Rickettsia rickettsii: An Enigmatic Pathogen. The Rickettsia - Host Interaction. A Preview of Rickettsial Gene Structure and Function. Persistent Infection with Coxiella burnetii in vitro and in vivo. Genetic Diversity of Coxiella burnetii. Molecular Strategies for Uptake and Intraphagosomal Growth of Coxiella burnetii in Non-Immune and Immune Hosts. The Immunobiology of Legionella pneumophila. Intracellular Parasitism of Shigellae. The Interaction of Mycobacterium leprae with the Immune System in Man and Experimental Animals. Microsporidian Spores as Missile Cells. Protein Transport and Membrane Biogenesis in Malaria-Infected Erythrocytes. Interactions of Malaria Parasites and Their Host Erythrocytes. Sexual and Mosquito Stages of Plasmodium falciparum. Active Modification of Host Cell Phagosomes by Toxoplasma gondii. Biology of Toxoplasma gondii Host Cell Entry - The Role of Recognition and Attachment for Invasion of Host Cells. Index.
James W. Moulder, Ph. D., is Professor Emeritus of Molecular Genetics and Cell Biology at The University of Chicago. He is presently a Visiting Scientist in the Department of Microbiology and Immunology at The University of Arizona, Tucson. After receiving S.B. and Ph. D. degrees in Biochemistry from The University of Chicago, Professor Moulder joined its faculty in 1944, where he remained, first in Microbiology and later in Molecular Genetics and Cell Biology, until his retirement in 1986. He was Chairman of the Department of Microbiology from 1959 through 1968. Professor Moulder was a Fellow of the John Simon Guggenheim Foundation and a Senior Fulbright Research Fellow in the Department of Biochemistry, University of Oxford, in 1952 to 1953. He received the Eli Lilly Award in Bacteriology in 1954 and was a Burroughs-Welcome Visiting Professor of Microbiology at Western Kentucky University in 1984. Professor Moulder was editor of The Journal of Infectious Diseases from 1957 through 1968. He has been a trustee of the Bergey’s Manual Trust since 1981. He is a member of the American Association for the Advancement of Science, the American Society for Microbiology, and the American Society for Biochemistry and Molecular Biology. He is also an honorary member of the American Society for Rickettsiology and Rickettsial Diseases. Professor Moulder’s chief research interest is the biochemistry of intracellular parasitism, with emphasis on members of the genus Chlamydia. He has written books, book chapters, reviews, and many original articles on this subject.