1st Edition

Learning from Disease in Pets A ‘One Health’ Model for Discovery

Edited By Rebecca A. Krimins Copyright 2021
    306 Pages 17 B/W Illustrations
    by CRC Press

    306 Pages 17 B/W Illustrations
    by CRC Press

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    Learning from Disease in Pets: A ‘One Health’ Model for Discovery is the first encompassing reference guide for veterinarians, researchers and physicians on conducting studies using spontaneous models of disease in animals. The study of naturally occurring disease in (pet) animals can help model our understanding of the biology, prevention and therapy of human and animal diseases. Studies of pet dogs, for instance, can aid treatment of complex medical problems such as cancer, orthopedic, cardiopulmonary, and neuro-inflammatory diseases, and zoonotic infections. Each chapter within this novel cross-species approach is contributed by a leader, or leaders, in their field of research.

    Using clinical trials to learn how pets with real diseases respond to therapy can lead to breakthroughs in human medicine, as well as benefiting pets suffering from otherwise debilitating illness. Despite similarities of diseases across species, there are very few spontaneous models of disease used in research compared with models where disease is induced in healthy laboratory animals. Many medical researchers and veterinarians have a multitude of questions regarding how to use naturally occurring diseases in pets for the discovery of treatments and diagnostics: this book will demonstrate how to safely make this happen.

    This book encourages veterinarians to build on and disseminate existing findings for the wider benefit of pets and humans. Many pets suffering from incurable illnesses may benefit from clinical trials; the book includes a section on the imperative communication styles necessary within the research environment and with clients, a compelling discussion on the ethics of using pets in veterinary clinical research, comprehensive tables of diseases that spontaneously occur in animals and humans, the regulatory requirements necessary to move therapy from benchside research to patient bedside, as well as intricate details on how to design a robust clinical study.



    Foreword by Chand Khanna, Ethos Veterinary

    1. The Contribution of Pets to Human and Veterinary Medicine by Rebecca Krimins, Johns Hopkins University

    2. Companion Animals Models of Human Disease by David Bruyette, Anivive LifeSciences
    3. Specific Diseases of Large Animals and Man by Timothy Lescun, Purdue University
    4. Cancer Research is Leading the Way by Diane Peters, Johns Hopkins University
    5. Investment Dynamics in the World of Pharma by Bryan Jones, Sollis Therapeutics
    6. How to Perform Research in Spontaneous Models of Disease by Kristen Khanna, Animal Clinical Investigations
    7. The Use of Animals in Research by Victoria Baxter, North Carolina State University
    8. DNA Methods in Veterinary Medicine by Alan Scott, Johns Hopkins University
    9. The Importance of Collecting Tissue from Pets by Rebecca Krimins, Johns Hopkins University
    10. The FDA New Animal Drug Approval Process by Jacob Michael Froehlich, Alice Ignaszewski and Anna O’Brien, FDA
    11. Clinical Trials, Patient Recruitment and Advertising, by Krista Vermillion, Vanderbilt University
    12. One Health: Animals, Humans and Our Planet by Radford Davis, Iowa State University
    13. Communications and Expectations by Kristen V. Khanna, Animal Clinical Investigations, and Karen Gozdan-Aiken, Elevate DVM
    14. Ethical Considerations by Steven M. Niemi, Harvard University
      • Appendix A: Funding for Veterinary Clinical Research

        Appendix B: Resources for Veterinary Clinical Research

        (also available as online Download)


      Dr. Rebecca Krimins is an Assistant Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science, with additional appointments in the Department of Anesthesiology and Critical Care Medicine and the Department of Molecular and Comparative Pathobiology. A native of Annapolis, Maryland, Dr. Krimins completed her veterinary anesthesia and analgesia residency at the Purdue University School of Veterinary Medicine. Dr. Krimins has more than 15 years of experience in managing critically ill patients during advanced imaging procedures and conducting cutting-edge clinical studies. Dr. Krimins’ specialty in veterinary anesthesia, sedation and pain management in combination with her experience in directing advanced clinical research offers each veterinary patient the best opportunities for diagnosis and therapy. Dr. Krimins works closely with each patient's personal veterinarian and pet family to ensure accurate and timely results that are crucial for therapeutic options. The Veterinary Clinical Trials Network at Johns Hopkins University is designed to leverage the expertise and platforms available at Johns Hopkins University in order to transform newly discovered diagnostics and therapeutics into real-life practical approaches that benefit veterinary patients

      The inclusion of naturally occurring disease in pet animals is an attractive and increasingly recognized approach to model our understanding of the biology, prevention and therapy of human disease. In this text, successful examples of this cross-species approach are reviewed in a variety of therapeutic areas, including the notable progress in oncology.

      -- Chand Khanna, DVM, PhD, DACVIM (Onc), DACVP (Hon), Chief Science Officer, Ethos Veterinary Health, and President, Ethos Discovery