Microwave Heating as a Tool for Sustainable Chemistry: 1st Edition (Paperback) book cover

Microwave Heating as a Tool for Sustainable Chemistry

1st Edition

Edited by Nicholas E. Leadbeater

CRC Press

290 pages | 215 B/W Illus.

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Paperback: 9781138111981
pub: 2017-05-22
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pub: 2010-09-02
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Shorter reaction times, higher product yields, and enhanced selectivity are some of the advantages microwave heating has over conventional methods, causing its use to transition from a curiosity to mainstream, both in industrial and academic settings. Microwave Heating as a Tool for Sustainable Chemistry showcases the application of microwave heating in a number of areas of preparative chemistry as well as in the biosciences.

From organic chemistry to materials and biological applications

The book begins with an introduction to microwave heating, the physical concepts behind it, its application in synthetic chemistry, and commercially available microwave equipment. It shows how microwave heating can be used to facilitate the clean and sustainable synthesis of organic compounds. The authors examine microwave heating as a tool for sustainable polymer chemistry, with discussions of the use of alternative solvents and feedstocks, the design of degradable polymeric materials, and recycling polymers. They then discuss the significant contribution made by microwave-promoted synthesis in the drug discovery process, with a focus on how the technology has been used to generate discovery chemistry libraries and as a tool for medicinal chemists. Other topics examined in this application-driven text include the use of microwave heating in the preparation of inorganic and organometallic compounds, in the production of inorganic materials, and in the area of biosciences.

Academic and industrial settings

The book examines the scale-up of microwave-promoted chemistry and describes the various approaches and the current commercially available microwave reactors available for scale-up. It also discusses microwave heating as a tool for teaching in the undergraduate organic chemistry laboratory. It explores curriculum, the broad range of reactions that can be performed, and the incorporation of green chemistry principles.

The author maintains a website with supplemental information.


"Overall this book covers many areas which utilise microwave heating technology to enhance one or many aspects of chemical transformations. The text is best suited to postgraduate students and academics with an interest in synthetic methodology and serves as an excellent starting point to flesh out ideas potentially applicable to microwave irradiation. Well worth a read and an excellent addition to any professional library."

—Luke C Henderson, Reviews, July 2011, No. 22, Vol 12

… valuable for process chemists and should be read by all those thinking about scaling up a microwave reaction or purchasing equipment.

— Trevor Laird, Editor, Organic Process Research & Development

This book is a useful complement to literature reviews and other books on the topic. For those who are interested in green and sustainable chemistry, it is well worth reading.

—Wei Zhang, University of Massachusetts, Boston, in Journal of the American Chemical Society

Table of Contents

Microwave Heating as a Tool for Sustainable Chemistry: An Introduction,Jason R. Schmink and Nicholas E. Leadbeater

Microwave Heating

Microwave Effects

Microwave-Assisted Synthesis

Commercially Available Microwave Equipment

Microwave Heating as a Tool for Organic Synthesis, Robert A. Stockland, Jr.

Solvent-Free Reactions

Reactions Using Organic Solvents

Reactions in Water

Asymmetric Transformations

Microwave Heating as a Tool for Sustainable Polymer Chemistry, Mauro Iannelli

Use of Alternative Solvents

Use of Alternative Feedstocks

Design of Degradable Polymeric Materials

Recycling Polymers

Microwave Heating as a Tool for Drug Discovery, Ping Cao and Nicholas E. Leadbeater

Microwave-Based Synthetic Methodologies for Generation of Discovery Chemistry Libraries

Microwave-Assisted Medicinal Chemistry

Microwave Heating as a Tool for Process Chemistry, Jonathan D. Moseley


Commercially Available Microwave Apparatus

Practical Considerations

Examples of Scale-Up

Other Applications in Process Chemistry

Energy Efficiency of Microwave Heating

Recent Developments in Scale-Up

Microwave Heating as a Tool for the Undergraduate Organic Chemistry Laboratory, Cynthia B. McGowan and Nicholas E. Leadbeater

Motivation for Incorporation of Microwave Heating as a Tool in the Undergraduate Laboratory

Examples of Published Teaching Materials Incorporating Microwave Heating into the Undergraduate Laboratory

Microwave Heating as a Tool for Inorganic and Organometallic Synthesis, Gregory L. Powell

Microwave-Promoted Coordination Chemistry

Microwave-Promoted Organometallic Chemistry

Microwave Heating as a Tool for Materials Chemistry, Steven L. Suib and Nicholas E. Leadbeater

Microwave Heating for Preparation of Adsorbents

Microwave Heating for Preparation of Battery Materials

Microwave Heating for Preparation of Ceramics

Microwave Heating for Preparation of Zeolite Materials

Examples of Other Materials Prepared Using Microwave Heating

Microwave Heating as a Tool for the Biosciences, Grace S. Vanier

Synthesis of Peptides

Synthesis of Modified Peptides

Microwave-Assisted Proteomics

Other Bioscience Applications of Microwave Heating

Future Perspectives


About the Series

Sustainability: Contributions through Science and Technology

Sustainability is rapidly moving from the wings to center stage. Overconsumption of nonrenewable and renewable resources, as well as the concomitant production of waste has brought the world to a crossroads. Green chemistry, along with other green sciences technologies, must play a leading role in bringing about a sustainable society. The Sustainability: Contributions through Science and Technology series focuses on the role science can play in developing technologies that lessen our environmental impact. This highly interdisciplinary series discusses significant and timely topics ranging from energy research to the implementation of sustainable technologies. Our intention is for scientists from a variety of disciplines to provide contributions that recognize how the development of green technologies affects the triple bottom line (society, economic, and environment). The series will be of interest to academics, researchers, professionals, business leaders, policy makers, and students, as well as individuals who want to know the basics of the science and technology of sustainability.

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Chemistry / General
SCIENCE / Chemistry / Organic
SCIENCE / Chemistry / Industrial & Technical