1st Edition

Modern Avenues in Metal-Nucleic Acid Chemistry

Edited By Jens Müller, Bernhard Lippert Copyright 2023
    464 Pages 89 Color & 71 B/W Illustrations
    by CRC Press

    464 Pages 89 Color & 71 B/W Illustrations
    by CRC Press

    Volume 25, entitled Modern Avenues in Metal-Nucleic Acid Chemistry, of the series Metal Ions in Life Sciences (MILS), provides a timely overview of selected relevant developments in a field which previously had a pronounced focus on fundamental chemistry aspects such as coordination principles, structural chemistry, and consequences for biological processes and disease-related medicinal issues. More recently, also as a consequence of the advent of supramolecular chemistry, advancements in nanochemistry, and new bio-analytical methods, novel aspects of this field have emerged. MILS-25 gives a state-of-the-art account on the present state of research in this field, addressing, among others, porous materials, non-covalent interactions, stimuli-responsive bioconjugates, DNA-templated metal arrays and nanoclusters, genotyping, guanine quadruplexes, and riboswitches. It consists of 15 comprehensive chapters with over 1600 citations, 160 figures (90 of them in color), with key contributions from 40 international experts from Europe, Asia, and America. It is an essential resource for scientists from numerous disciplines, ranging from materials science to biochemistry, by way of classical chemistry and physics.

    • It offers an update on nucleic acid – metal complex bioconjugates and their applications
    • It provides an insight into coordination polymers involving nucleic acid components
    • It covers a wide range of nucleic acids, from DNA duplexes, triplexes and quadruplexes to RNA

    Chapter 1 Porous materials built up from metal-nucleobase materials

    Garikoitz Beobide, Oscar Castillo, Antonio Luque, and Sonia Pérez-Yáñez

    Chapter 2 Cytosine and its derivatives as useful tools to build unusual and fascinating architectures

    Teresa F. Mastropietro and Giovanni De Munno

    Chapter 3 Coordination polymers with nucleobase derivatives: from electronic nanodevices to sensors

    Noelia Maldonado and Pilar Amo-Ochoa

    Chapter 4 Heavy coinage metal nucleobase, nucleoside and (oligo)nucleotide systems: recent developments in self-assembly, opto-electronics and DNA integration

    Andrew Houlton

    Chapter 5 Interplay between non-covalent interactions and metal ions in nucleic acids and their constituents

    Miquel Barceló-Oliver, Antonio Frontera, Juan Jesús Fiol, Ángel García-Raso, and Ángel Terrón

    Chapter 6 Biological implications of metal-nucleobase complexes

    Saurabh Joshi, Ankita Jaiswal, Rajneesh Kumar Prajapati, and Sandeep Verma

    Chapter 7 Stimuli-responsive DNA-binding metal complexes

    Tim Kench and Ramon Vilar

    Chapter 8 How do cationic Pt(II) complexes modify the higher-order structure of DNA?

    Seiji Komeda, Masako Uemura, Yuko Yoshikawa, and Kenichi Yoshikawa

    Chapter 9 Metals in genotyping – from SNPs to sequencing

    Tuomas Lönnberg

    Chapter 10 Nucleic acids for the preparation and control of continuous hybrid metallic assemblies

    Miguel A. Galindo, Fátima Linares, Alicia Domínguez-Martín, and Antonio Pérez-Romero

    Chapter 11 Recent advances in the development of metal-responsive functional DNAs based on metal-mediated artificial base pairing

    Yusuke Takezawa and Mitsuhiko Shionoya

    Chapter 12 Nucleic acid-templated metal nanoclusters

    Rweetuparna Guha and Stacy M. Copp

    Chapter 13 G-Quadruplex nucleic acids and the role of metal ions: insights from quantum chemical bonding analyses

    Celine Nieuwland and Célia Fonseca Guerra

    Chapter 14 Transition Metal-Binding G-Quadruplex DNA

    Lukas M. Stratmann and Guido H. Clever

    Chapter 15 Metabolite regulation by riboswitches: the role of metal ions in folding, ligand binding, and functionality

    Maria Reichenbach, Sofia Gallo, and Roland K.O. Sigel



    Jens Müller holds a Chair of Inorganic Chemistry (2018) at the Department of Chemistry and Pharmacy, Westfälische Wilhelms-Universität Münster, Germany. He obtained his doctoral degree (1999, summa cum laude) from the Technische Universität Dortmund, working with Bernhard Lippert. After a postdoctoral stay in the groups of Stephen J. Lippard (MIT) and Gerhard Wagner (Harvard Medical School), he started his independent career at the Technische Universität Dortmund in 2002, funded by the prestigious Emmy Noether Programme. After having received his Habilitation in 2008, he became Professor of Inorganic Chemistry at the Westfälische Wilhelms-Universität Münster. His research focuses on the bioinorganic chemistry of nucleic acids, with a particular interest in metal-mediated base pairing. He was Dean of Student Affairs from 2011–2014, Chair of the European research initiative COST Action CM1105 ("Functional metal complexes that bind to biomolecules"), and guest Editor of several themed issues of chemistry journals. Since 2018, he has served as the Editor of Inorganica Chimica Acta. He is the Chair of EuroBIC-17 (2024 in Münster, Germany).

    Bernhard Lippert retired in 2011 from Chair of Bioinorganic Chemistry at the Technische Universität Dortmund, Germany. He received his Ph.D. degree from Technische Universität München (TUM), Germany, in 1974. Following a postdoctoral stay with Barnett Rosenberg at the Biophysics Department of Michigan State University, USA, he started his independent research at TUM, which was focused on fundamental aspects of interactions of metal species, notably of Pt, with nucleobases, as well as supramolecular constructs derived from these components. During his career at TUM, the University of Freiburg, Germany, and TU Dortmund, he has trained 70 PhD students and in addition numerous Bachelor and Master students as well as postdoctoral fellows, a fair number of whom eventually earned academic positions. Results of his group’s work are documented in over 400 refereed scientific articles and have been communicated at many international conferences and lectureships. He served the community as Editorial Board member of several journals (Inorg. Chem., Dalton Trans., Inorg. Chim. Acta, J. Biol. Inorg. Chem., Biometals), and was the Editor of Inorg. Chim. Acta from 2008 to 2019. He was (Co)-Editor of a number of themed issues in chemistry journals, and Editor of the book Cisplatin: Chemistry and Biochemistry of a Leading Anticancer Drug, which reviewed the knowledge on Pt antitumor complexes at the turn of the century. He has been involved in the management of European research activities in the COST frame, has been the Secretary of EuroBIC conferences for 11 years and has organized numerous scientific meetings such as the "EURESCO Research conference on the Inorganic Side of Molecular Architecture" (2002), EuroBIC-7 (2004), and "4th EuCheMS Conference on Nitrogen Ligands" (2008), among others. Since 2014 he has been an Honorary Member of the Society of Biological Inorganic Chemistry (SBIC).