Molecular Manipulation with Atomic Force Microscopy: 1st Edition (Hardback) book cover

Molecular Manipulation with Atomic Force Microscopy

1st Edition

Edited by Anne-Sophie Duwez, Nicolas Willet

CRC Press

287 pages | 118 B/W Illus.

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Description

With the invention of scanning probe techniques in the early 1980s, scientists can now play with single atoms, single molecules, and even single bonds. Force, dynamics, and function can now be probed at the single-molecule level. Molecular Manipulation with Atomic Force Microscopy (AFM) presents a series of topics that discuss concepts and methodologies used to manipulate and study single (bio)molecules with AFM. The first part is dedicated to the pulling of single molecules with force spectroscopy to investigate molecular interactions, mechanics, and mechanochemical processes, and the second part to the manipulation, repositioning, and targeted delivery of single molecules on substrates.

Single molecule manipulation is an exciting area of research which made important breakthroughs in nanoscience and which could find potential applications in a diverse range of disciplines, including chemistry, biology, physics, material and polymer science, and engineering. New and experienced AFM researchers looking for applications beyond imaging will find a wealth of information in this informative volume.

Reviews

Single molecule manipulation is an exciting area of research which made important breakthroughs in nanoscience and which could find potential applications in a diverse range of disciplines, including chemistry, biology, physics, material and polymer science, and engineering. New and experienced AFM researchers looking for applications beyond imaging will find a wealth of information in this informative volume.

Anticancer Research, 32: 715-720 (2012)

Table of Contents

Pulling on Single Molecules with Force Spectroscopy

Molecular Recognition Force Spectroscopy

Nicolas Willet, Constanze Lamprecht, Christian Rankl, Martina Rangl, Rhiannon Creasey, Andreas Ebner, Nicolas H. Voelcker, and Peter Hinterdorfer

Mechanics of Proteins and Tailored Mechanics of Engineered Proteins

Ashlee Jollymore, Yi Cao, and Hongbin Li

Mechanics of Polysaccharides

Whasil Lee, Piotr E. Marszalek, Xiancheng Zeng, and Weitao Yang

Mechanics and Interactions in DNA and RNA

Robert Ros

Mechanics of Synthetic Polymers

Wenke Zhang, Ying Yu, and Xi Zhang

Interplays between Chemistry and Mechanics in Single Molecules

Dhruv Kumar and Bruno Samorì

Manipulation, Repositioning, and Targeted Delivery of Single Molecules on Substrates

Molecular Construction: Pushing, Moving, Stretching, and Connecting Individual Molecules

Fouzia Bano and Anne-Sophie Duwez

Extracting Molecules from Surfaces

Atsushi Ikai, Rehana Afrin, Takahiro Nakayama, and Shin-ichi Machida

Single Molecule Delivery by Mechanochemistry

Tiziana Svaldo-Lanero and Anne-Sophie Duwez

Single-Molecule Cut and Paste

Stefan W. Stahl, Mathias Strackharn, and Hermann E. Gaub

Index

About the Editors

Anne-Sophie Duwez received her Ph.D. in Chemistry in 1997 from the University of Namur, Belgium. She then moved to the Catholic University of Louvain as a Post-doctoral Researcher of the Belgian National Fund for Scientific Research. In 2002-2003, she was visiting scientist at the Max-Planck Institute for Polymer Research in Mainz, Germany. She then returned to the Catholic University of Louvain as a senior scientist to develop AFM-based single molecule force spectroscopy. In 2006, she took up the Chair of Chemistry at Surfaces at the University of Liège. In 2007, she received a Starting Grant from the National Fund for Scientific Research to set up a new lab dedicated to advanced AFM techniques. She is currently professor of surface chemistry, chemistry of organic and bio materials, and nanotechnology. Her research interests focus on the development of AFM-based techniques, probes, and methods to manipulate single molecules. They include the investigation of mechanochemical processes in bio- and synthetic systems and the design of single molecule devices.

Nicolas Willet studied chemistry at the University of Liège, Belgium. He studied protein folding during his master thesis and received his Ph.D. in 2007 for his work on the synthesis and characterization of triblock copolymer self-assemblies, carried out under the supervision of Professor Robert Jérôme (polymer chemistry). He then moved to the team of Professor Anne-Sophie Duwez where he performed AFM force spectroscopy on bio-inspired polymers. After his postdoctoral work with Professor Peter Hinterdorfer at the Institute of Biophysics of the University of Linz, Austria, he went back to the University of Liège in 2011, where he is currently working as an FNRS postdoctoral researcher. His research interests concern functional and responsive polymers, single-molecule force spectroscopy, molecular recognition, with a particular focus on the investigation of biological macromolecules' conformation.

Subject Categories

BISAC Subject Codes/Headings:
SCI013060
SCIENCE / Chemistry / Industrial & Technical
SCI077000
SCIENCE / Solid State Physics
TEC021000
TECHNOLOGY & ENGINEERING / Material Science