This book describes the methodology of monoclonal antibody-mediated immunohistochemistry, as applied to practical tissue diagnosis. It focuses on human disease and discusses the spectrum of monoclonal antibodies in relation to its utility in solving differential diagnostic problems.
1. Theoretical and Technical Considerations for the Use of Monoclonal Antibodies in Diagnostic Immunohistochemistry 2. Monoclonal Antibodies to Cytokeratins in Diagnostic Immunocytochemistry 3. Monoclonal Antibodies to Vimentin 4. Antibodies to Desmin in Diagnostic Pathology 5. Neurofilament and Glial Filament Proteins 6. Monoclonal Antibodies to Lymphoreticular and Myeloid Antigens 7. Monoclonal Antibodies to Human Milk Fat Globule Proteins 8. Monoclonal Antibodies to Leukocyte Common Antigen 9. Monoclonal Antibodies to Monomorphic Human Histocompatibility Antigens: Class I (HLA A, B, C), Class II (HLA-DR or IA-Like Antigen), and (β2 Microglobulin 10. Monoclonal and Polyclonal Antibodies to Blood Group Antigens A, B, and H 11. Immunohistochemical Localization of Estrogen Receptors with Monoclonal Antibodies 12. Monoclonal and Polyclonal Antibodies to Prostatic Acid Phosphatase and Prostatic-Specific Antigen 13. Antibodies to Creatine Kinase Isoenzymes 14. The Anterior Pituitary Hormones with Special Reference to the Immunocytology of Pituitary Adenomas and Neuroendocrine Neoplasms 15. The Use of Monoclonal Antibodies to S100 Protein in Diagnostic Immunohistochemistry 16. Gross Cystic Disease Fluid Protein-15 17. Monoclonal Antibodies to Chromogranin: Characterization and Comparison with Other "Neuroendocrine" Markers 18. Monoclonal Antibodies to Carcinoembryonic Antigen in Diagnostic Immunohistochemistry 19. Antibodies to Placental Alkaline Phosphatase 20. Antibodies to Human Chorionic Gonadotropin 21. The Use of Monoclonal Antibodies in the Search for Tumor-Specific Antigens 22. Monoclonal Antibodies to Microbial Antigens in Diagnostic Pathology 23. Monoclonal Antibodies in Diagnostic Immunohistology: A Brief Perspective and a Look at the Future