Nanobiophysics is a new branch of science that operates at the interface of physics, biology, chemistry, material science, nanotechnology, and medicine. This book is the first one devoted to nanobiophysics and introduces this field with a focus on some selected topics related to the physics of biomolecular nanosystems, including nucleosomal DNA and model lipid membranes, nanobiohybrids involving DNA/RNA and single-walled carbon nanotubes, biomolecules deposited on nanoparticles, and nanostructured surfaces. It describes unique experimental physical methods that are used to study nanosized biostructures. It outlines the applied aspects of nanobiophysics, considering the state of art in the fabrication of two types of sensors: gas sensors, with a focus on breath gas detection, and nanophotonic sensors, with a focus on polycyclic aromatic hydrocarbon detection in water samples. It also covers the development of nanoscale scaffolds for delivery of therapeutic nucleic acids to cells, which is an important example of the possible application of nanobiophysics researches in nanomedicine.
Table of Contents
Quantum-Mechanical Investigations of Non-Covalent Interactions of Carbon Materials
Hybrids of siRNA with Carbon Nanotubes as RNA Interference Instruments
Single-Walled Carbon Nanotubes Interfaced with DNA/RNA
Nucleosome as an Example of a Nanosystem Formation: Structural Dynamics of Nucleosomal DNA
Structure Diagnostics of Biorelevant Associates and Complexes in Liquid Nanosystems by Small-Angle Scattering
Liquid Crystal Ordering and Nanostructuring in Model Lipid Membranes
Interactions of Biologically Active Redox-Sensitive Dyes with Nanomaterials: Mass Spectrometric Diagnostics
Nanosized Complexes of Bioorganic Molecules in Low-Temperature Matrices
Kinetics Framework for the Nanoscale Description of Environment-Induced Transition Processes in Biomolecular Structures
Polymer-Mediated Interactions between Nanocolloids and Their Effect on the Coagulation-Fragmentation of Colloid
Point-Contact Sensors and Their Medical Applications for Breath Analysis: A Review
Nanophotonic Sensor for Polycyclic Aromatic Hydrocarbon Detection
Victor Alexeevich Karachevtsev is head of the Molecular Biophysics Department and a professor of physics and mathematics at B. Verkin Institute for Low Temperature Physics and Engineering of the National Academy of Sciences of Ukraine (ILTPE), Ukraine. He received his master’s degree in physics (1977) from the University of Kharkov, Ukraine, and obtained his PhD (1986) and Dr. Sci. (1997) in physics and mathematics from ILTPE. He received the State Award of Ukraine in Science and Technology in 2012. His research interests concern the functionalization of carbon nanomaterials with biopolymers, enzymes, proteins, etc., and the developments of their applications in biosensing.
"Nanoscale materials, their physical and chemical properties, and even their biological effects have emerged as a new major branch of science. Interdisciplinary fields are always intriguing and exciting but also difficult to master. This book is an important contribution by an excellent group of scientists who came together to discuss the most relevant aspects of nanoscale materials from the standpoint of biophysics. It summarizes the new findings and developments in the field. The book is a valuable read for newcomers in the field, specialists in other aspects of nanomaterials, and scientists already working in nanobiophysics."
— Prof. Károly Vékey, Research Centre for Natural Sciences, Hungary