Nanoparticle-Based Drug Delivery in Cancer Treatment  book cover
1st Edition

Nanoparticle-Based Drug Delivery in Cancer Treatment

ISBN 9781032135205
Published March 15, 2022 by CRC Press
558 Pages 87 Color & 161 B/W Illustrations

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Book Description

The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field.

Key Features:

  • Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy
  • Focuses on material platforms that establish NPs and both localized and controlled gene silencing
  • Emphasizes the most promising systems for clinical application
  • Surveys progress in nanoparticle-based nanomedicine in cancer treatment
  • Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells

This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.

Table of Contents

Chapter 01

The advantages and versatility of carrier—free nanodrugs and nanoparticles systems for cancer therapy

Chapter 02

Strategies, design, and chemistry in siRNA delivery vehicles systems for cancer therapy

Chapter 03

DNA/RNA nanoparticles structures for siRNA deliver applications

Chapter 04

Co-delivery in nanoparticle-based siRNA for cancer therapy

Chapter 05

Small interfering RNAs (siRNAs), MicroRNAs and NPs in gynecological cancers

Chapter 06

Nanoparticle–based RNA (siRNA) combination therapy toward overcoming drug resistance in cancer

Chapter 07

Imaging modalities delivery of RNAi therapeutics in cancer therapy and clinical applications

Chapter 08

Recent development of Silica nanoparticles as delivery biomedical applications for cancer imaging and therapy

Chapter 09

Application of carbon nanotubes (CNTs) in cancer vaccines as drug delivery tools

Chapter 10

Development of oligonucleotides delivery, (siRNAs), and (miRNA) systems for anticancer therapeutic strategy immunotherapy

Chapter 11

Pharmacogenomics-synergistic strategies using a chimerical peptide for enhanced chemotherapy based on ROS and DNA nanosystem

Chapter 12

Pharmacokinetics, biodistribution and therapeutic applications of recently-developed siRNA and DNA repair genes recurrence

Chapter 13

Nanotechnologies assemblies of siRNA and chemotherapeutic drugs co-delivered for cancer therapeutic applications

Chapter 14

Targeted systemic combinatorial delivery of siRNA polyplexes-Functional quantum dot-siRNA nanoplexes

Chapter 15

Recent advances of nanotechnologies for cancer immunotherapy treatment


List of Abbreviations

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Prof. Loutfy H. Madkour is a professor of physical chemistry and nanoscience at Tanta University (Egypt). He received his BSc, MSc, and PhD in physical chemistry from the Cairo, Minia, and Tanta universities in Egypt, respectively. He has published 200 peer-reviewed original research articles, 20 review articles, and 8 books. He is an editorial board member of several international journals, including International Journal of Industrial Chemistry (IJIC-Springer), International Journal of Ground Sediment & Water, Global Drugs and Therapeutics, Chronicles of Pharmaceutical Science, Journal of Targeted Drug Delivery, UPI Journal of Pharmaceutical, Medical and Health Sciences, Global Journal of Nanomedicine, Clinical Pharmacology and Toxicology Research, Journal of Pharmacology & Pharmaceutical Research, LOJ Pharmacology & Clinical Research, CPQ Medicine, Pharmaceutical Sciences & Analytical Research Journal, Japan Journal of Research, Organic & Medicinal Chemistry International Journal, Nanotechnology & Applications, Materials Science Journal, Journal of Chemical Science and Chemical Engineering (Journals of– JCSCE), United Journal of Nanotechnology and Medicine, Clinical Practice (Therapy) journal, Journal of Materials New Horizons, Journal of Radiology and Medical Imaging. MedDocs Publishers, World Journal of Pharmacy and Pharmaceutical Sciences WJPPS and Journal of Material Science and Technology Research – RBM.