332 Pages 50 B/W Illustrations
    by CRC Press

    This new edition presents an integrated approach to neurotoxicology, the study of organisms’ responses to changes in their environment and how interruption of the flow of information by chemical exposure causes a wide range of effects – from learning deficits, sensory disturbances in the extremities, and muscle weakness to seizures and signs similar to neurodegenerative disorders such as Parkinson’s or Alzheimer’s disease.  It is an essential resource for understanding the sites and mechanisms of neurotoxicity, for formulating testable hypotheses about the effects of neurotoxicants, and for improving the risk assessment process. 

    1. Molecular Approaches to Identify Specific Modes of Action for Neurotoxicity In vitro

    Ram Ramabhadran, Steven O. Simmons, William R. Mundy

    2. Bioinformatic and Computational Approaches for Analysis of Genomics Data in Neurotoxicology Research

    Julia M Gohlke, Willard M. Freeman, Kent E. Vrana

    3. Neurotoxicology of Barriers in the Developing Brain

    Norman R Saunders, Mark D Habgood, Katarzyna M Dziegielewska

    4. Thyroid Hormones – Impact on the Developing Brain: Possible Mechanisms of Neurotoxicity

    Mary E. Gilbert, R.T. Zoeller

    5. Dopaminergic Nerves as Targets for Neurotoxins

    Richard M. Kostrzewa, Lucyna Antkiewicz-Michaluk, Francisco Fornai

    6. Endocrine Disruption and Senescence: Consequences for Reproductive Endocrine and Neuroendocrine Systems, Behavioral Responses and Immune Function

    Mary Ann Ottinger, Emma Lavoie, Karen Dean, Brandon Sitzmann, Michael J. Quinn, Jr.

    7. White Fat Tissue, Obesity, and Possible Role in Neurodegeneration

    Palaniyandi Ravanan, Christian Lefebvre d’Hellencourt

    8. Microglia: Neuroprotective and Neurodestructive Properties

    G. Jean Harry

    9. The Slice Culture Model: Considerations for Neurotoxicity Assessment

    Andrew D. Kraft

    10. Design-Based Stereology and Video Densitometry For Assessment Of Neurotoxicological Damage

    P. R. Mouton, M. N. Gordon

    11. Effect of Neurotoxins on Brain Tissue and Function Revealed Through in vivo MR Imaging and Spectroscopy

    Margaret J. Rosenbloom, Edith V. Sullivan, Adolf Pfefferbaum

    12. Principles of Behavioral Phenotyping of Neonatal and Adult Mice

    S. H. Brunssen, S. S. Moy, G. E. Kissling


    G. Jean Harry, Ph.D., is Head of the Neurotoxicology Group at the National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH) and Adjunct Associate Professor at the University of North Carolina (UNC) and Duke University. She obtained an M.S. in PsychoPharmacology from Virginia Commonwealth University (VCU) in 1977 and a Ph.D. in NeuroPharmacology from VCU in 1981. Dr Harry is currently an Associate Editor for Neurotoxicology.

    Hugh A. Tilson, Ph.D. received his doctorate in 1971 from the University of Minnesota and postdoctoral training in Pharmacology at Michigan State University. In 2005, Dr. Tilson was named National Program Director for human health research at the Office of Research and Development at the U.S. Environmental Protection Agency. He joined Environmental Health Perspectives as Editor-in-Chief in 2007.