1st Edition

Non-Classical Ion Channels in the Nervous System

Edited By

Xu Tian-le


Long-Jun Wu

  • Available for pre-order. Item will ship after July 15, 2021
ISBN 9780367623951
July 15, 2021 Forthcoming by CRC Press
464 Pages 39 Color & 1 B/W Illustrations

USD $220.00

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Book Description

Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.

Table of Contents

Chapter 1: Endogenous activation and neurophysiological functions of acid-sensing ion channels

Author: Wei-Zheng Zeng, Yi-Zhi Wang, Tian-Le Xu*

Chapter 2:
Acid-sensing ion channels and synaptic plasticity: a revisit

Author: Ming-Gang Liu*, Michael X. Zhu, Tina-Le Xu*

Chapter 3:
Trimeric scaffold ligand-gated ion channels

Author: Xiao-Na Yang, Si-Yu Wang, Jin Wang, Ye Yu*

Chapter 4: Eukaryotic mechanosensitive ion channels

Author: Wei-Zheng Zeng*, Bailong Xiao*

Chapter 5: Ion channels in human pluripotent stem cells and their neural derivatives

Authors: Ritika Raghavan, Robert Juniewicz, Maharaib Syed, Michael Lin, Peng Jiang*

Chapter 6:
Exocytosis of non-classical neurotransmitters

Author: Xiao Su, Vincent R. Mirabella, Kenneth G. Paradiso and Zhiping P. Pang*

Chapter 7: Nonclassical ion channels in leaning and memory

Author: Ze-Jie Lin, Xue Gu, Tian-Le Xu, Wei-Guang Li*

Chapter 8: Neuropeptide regulation of ion channels and food intake

Author: Xiaobing Zhang*

Chapter 9: Prefrontal inhibitory signaling in the control of social behaviors

Author: Qian Yang, Jun Wang,Han Xu*

Chapter 10: Studying brain function using non-human primate models

Author: Neng Gong*

Chapter 11: Application of in vivo Ca2+ imaging in the pathological study of autism spectrum disorders

Author: Pan Xu, Yuanlei Yue, Hui Lu*

Chapter 12: Nonclassical ion channels in depression

Author: Zahra Farzinpour, Zhi Zhang*

Chapter 13: Ion channels of reward pathway in drug abuse

Author: Wen Zhang*

Chapter 14:
Ion channel conformational coupling in ischemic neuronal death

Author: Yi-Zhi Wang*, Michael X. Zhu*

Chapter 15: Nonclassical ion channels and ischemia

Author: Jun Gao*

Chapter 16:
Transient receptor potential channels and itch

Author: Mahar Fatima, Jingyi Liu, Bo Duan*

Chapter 17: Two-pore domain potassium channels in pain and depression

Author: Shaoying Zhang, Huaiyu Yang*

Chapter 18: Lysosomal ion channels and human diseases

Author: Peng Huang, Mengnan Xu, Yi Wu, Xian-Ping Dong*

Chapter 19: Microglial voltage-gated proton channel Hv1 in neurological disorders

Author: Madhuvika Murugan, Long-Jun Wu*

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Tian-Le Xu, PhD, Principal Investigator and Professor

Collaborative Innovation Center for Brain Science, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai

Dr. Tian-Le Xu obtained PhD of Neurobiology from Fourth Military Medical University. He did his postdoc training at Kyushu University and then joined University of Science and Technology of China as Professor. He was a principal investigator at Institute of Neuroscience, Chinese Academy of Sciences. Currently, he is Professor at Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine. Dr. Xu’s research focuses on neuronal signaling and related neural disorders including chronic pain and ischemic stroke, with an emphasis on the role of acid-sensing ion channels (ASICs) in these processes. The research from Dr. Xu’s lab has unveiled rich and new knowledge on the regulation and diverse functions of ASICs in health and disease.


Long-Jun Wu, PhD, Professor and Consultant

Department of Neurology, Mayo Clinic

Dr. Long-Jun Wu received PhD of Neurobiology from University of Science and Technology of China. After postdoc trainings at University of Toronto and Harvard Medical School, Dr. Wu was Instructor at Harvard Medical School and then Assistant Professor at Rutgers University. Currently, he is Professor and Consultant at Department of Neurology, Mayo Clinic. Dr. Wu’s recent research primarily focuses on the neuroimmune interaction, particularly the function of microglial ion channels and receptors, in normal and diseased brain. By understanding and manipulating microglial functions, Dr. Wu’s research aim to develop potential therapeutics targeting microglia in the treatment of various neurological disorders, such as epilepsy, chronic pain, stroke, neurodegeneration and autoimmune neurology.