Nonclassical Ion Channels in the Nervous System  book cover
1st Edition

Nonclassical Ion Channels in the Nervous System

Edited By

Xu Tian-le


Long-Jun Wu

ISBN 9780367623951
Published August 20, 2021 by CRC Press
427 Pages 39 Color & 1 B/W Illustrations

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Book Description

Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.

Table of Contents




1. Endogenous Activation and Neurophysiological Functions of Acid-Sensing Ion Channels

Wei-Zheng Zeng, Yi-Zhi Wang, and Tian-Le Xu

2. Acid-Sensing Ion Channels and Synaptic Plasticity: A Revisit

Ming-Gang Liu, Michael X. Zhu, and Tian-Le Xu

3. Trimeric Scaffold Ligand-Gated Ion Channels

Xiao-Na Yang, Si-Yu Wang, Jin Wang, and Ye Yu

4. Eukaryotic Mechanosensitive Ion Channels

Wei-Zheng Zeng and Bailong Xiao

5. Ion Channels in Human Pluripotent Stem Cells and Their Neural Derivatives

Ritika Raghavan, Robert Juniewicz, Maharaib Syed, Michael Lin, and Peng Jiang

6. Exocytosis of Nonclassical Neurotransmitters

Xiao Su, Vincent R. Mirabella, Kenneth G. Paradiso, and Zhiping P. Pang

7. Nonclassical Ion Channels in Learning and Memory

Ze-Jie Lin, Xue Gu, Tian-Le Xu, and Wei-Guang Li

8. Neuropeptide Regulation of Ion Channels and Food Intake

Xiaobing Zhang

9. Prefrontal Inhibitory Signaling in the Control of Social Behaviors

Qian Yang, Jun Wang, and Han Xu

10. Studying Brain Function Using Non-human Primate Models

Neng Gong

11. Application of In Vivo Ca2+ Imaging in the Pathological Study of Autism Spectrum Disorders

Pan Xu, Yuanlei Yue, and Hui Lu

12. Nonclassical Ion Channels in Depression

Zahra Farzinpour and Zhi Zhang

13. Ion Channels of Reward Pathway in Drug Abuse

Wen Zhang

14. Ion Channel Conformational Coupling in Ischemic Neuronal Death

Yi-Zhi Wang and Michael X. Zhu

15. Nonclassical Ion Channels and Ischemia

Jun Gao and Hui-Xin Zhang

16. Transient Receptor Potential Channels and Itch

Mahar Fatima, Jingyi Liu, and Bo Duan

17. Two-Pore Domain Potassium Channels in Pain and Depression

Shaoying Zhang and Huaiyu Yang

18. Lysosomal Ion Channels and Human Diseases

Peng Huang, Mengnan Xu, Yi Wu, and Xian-Ping Dong

19. Microglial Voltage-Gated Proton Channel Hv1 in Neurological Disorders

Madhuvika Murugan and Long-Jun Wu


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Tian-Le Xu, PhD, Principal Investigator and Professor

Collaborative Innovation Center for Brain Science, Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine, Shanghai

Dr. Tian-Le Xu obtained PhD of Neurobiology from Fourth Military Medical University. He did his postdoc training at Kyushu University and then joined University of Science and Technology of China as Professor. He was a principal investigator at Institute of Neuroscience, Chinese Academy of Sciences. Currently, he is Professor at Department of Anatomy and Physiology, Shanghai Jiao Tong University School of Medicine. Dr. Xu’s research focuses on neuronal signaling and related neural disorders including chronic pain and ischemic stroke, with an emphasis on the role of acid-sensing ion channels (ASICs) in these processes. The research from Dr. Xu’s lab has unveiled rich and new knowledge on the regulation and diverse functions of ASICs in health and disease.


Long-Jun Wu, PhD, Professor and Consultant

Department of Neurology, Mayo Clinic

Dr. Long-Jun Wu received PhD of Neurobiology from University of Science and Technology of China. After postdoc trainings at University of Toronto and Harvard Medical School, Dr. Wu was Instructor at Harvard Medical School and then Assistant Professor at Rutgers University. Currently, he is Professor and Consultant at Department of Neurology, Mayo Clinic. Dr. Wu’s recent research primarily focuses on the neuroimmune interaction, particularly the function of microglial ion channels and receptors, in normal and diseased brain. By understanding and manipulating microglial functions, Dr. Wu’s research aim to develop potential therapeutics targeting microglia in the treatment of various neurological disorders, such as epilepsy, chronic pain, stroke, neurodegeneration and autoimmune neurology.