Ocular Drug Delivery Systems: Barriers and Application of Nanoparticulate Systems, 1st Edition (Hardback) book cover

Ocular Drug Delivery Systems

Barriers and Application of Nanoparticulate Systems, 1st Edition

Edited by Deepak Thassu, Gerald J. Chader

CRC Press

473 pages | 11 Color Illus. | 103 B/W Illus.

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pub: 2012-10-02
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Drug discovery for ocular diseases has taken great strides in the last two decades. From cornea to choroid, new drugs have been formulated to address a great variety of ocular diseases. Yet without good drug delivery systems, these drugs are less effective than they might be or could even cause serious side effects. Ocular Drug Delivery Systems: Barriers and Application of Nanoparticulate Systems presents research on the development of currently marketed devices and recent trends in the topical delivery of drugs to the posterior of the eye.

With contributions from leading pharmaceutical researchers and industry experts, eye researchers, surgeons, pharmacologists from academia, the National Eye Institute, and leading ophthalmic companies such as Pfizer, Allergan, and Novartis, the book presents the state of the art in the use of nanoparticles in ocular drug delivery systems and also sets the stage for future developments.

This volume provides both a current evaluation and a future roadmap for developments in ocular drug delivery. The subjects range from biological needs to material challenges and finally to clinical applications for improving drug delivery for conditions where treatments already exist. It also explores areas where effective drugs may be currently available but yet need a safe, efficient, and efficacious delivery vehicle.

Table of Contents

Basic Considerations

Nanoparticle-Based Therapeutics: An Overview

Deepak Thassu, Kris Holt, and Gerald J. Chader

Eye Anatomy, Physiology and Ocular Barriers: Basic Considerations for Drug Delivery

Gerald J. Chader and Deepak Thassu

Animal Models to Evaluate Ocular Nanoparticular Drug Delivery Systems

Vinson M. Wang, Jingsheng Tuo, and Chi-Chao Chan

Computer Modeling for Ocular Drug Delivery

Paul J. Missel

Challenges in the Development of Nanotechnology-Based Ophthalmic Systems

Banu S. Zolnik, Sheriza Baksh, and Nakissa Sadrieh

Ocular Barriers

Blood–Retinal Barrier: The Fundamentals

Rosa Fernandes, Andreia Gonçalves, and José Cunha-Vaz

Barriers to Transscleral Drug Delivery to the Retina

Alexandra Almazan, Susan S. Lee, Aron D. Ross, and Michael R. Robinson

Ocular Compartment Drug Delivery

Drug Delivery to the Vitreous Humor

Francine Behar-Cohen

Transscleral and Suprachoroidal Drug Delivery

Damian E. Berezovsky and Henry F. Edelhauser

Protein Drug Delivery to Retina and Choroid

Hongwen M. Rivers and Patrick M. Hughes

Transscleral Drug Delivery to the Posterior Segment of the Eye

Bernard F. Godley, Cheryl L. Rowe-Rendleman, Ed Kraft, and Gabriella Kulp

Drug Delivery to the Suprachoroidal Space

Sung Won Cho and Timothy W. Olsen

Use of Nanoparticles in the Treatment of Age-Related Macular Degeneration, Glaucoma, and Other Degenerative Retinal Diseases

Marco A. Zarbin, Carlo Montemagno, James F. Leary, and Robert Ritch

Drug Delivery Systems

Drug Molecule Characteristics, Drug Delivery Strategies and Their Impact on Ophthalmic Drug Delivery to Anterior versus Posterior Segments

Kay D. Rittenhouse

Surface Modulation of Nanoparticles

Deepak Thassu and Kris Holt

Nanoparticles for the Treatment of Retinal Diseases

Amin Famili and Uday B. Kompella

Gene-Based Medicine for Ocular Diseases

Shannon M. Conley and Muna I. Naash

Stealth-Type Polymeric Nanoparticles with Encapsulated Betamethasone Phosphate for Treatment of Intraocular Inflammation

Tsutomu Sakai, Tsutomu Ishihara, and Megumu Higaki

Technology and Materials Development

Nanotechnology-Guided Imaging of Retinal Vascular Disease

Joshua R. Trantum and Ashwath Jayagopal

Photoresponsive Polymers for Ocular Drug Delivery

Laura A. Wells and Heather Sheardown

Nanosuspensions in Ocular Drug Delivery Systems

Himanshu Bhattacharjee and Sonia Bedi

About the Editors

Deepak Thassu is the Vice President of Pharmaceutical Development at Pharmanova, Inc., in Victor, New York.

Gerald Chader is Chief Scientific Officer of the Doheny Retina Institute at USC Medical School in Los Angeles.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacy
MEDICAL / Surgery / General
SCIENCE / Biotechnology
SCIENCE / Chemistry / General