1st Edition

Ocular Drug Delivery Systems Barriers and Application of Nanoparticulate Systems

Edited By Deepak Thassu, Gerald J. Chader Copyright 2013
    473 Pages 11 Color & 103 B/W Illustrations
    by CRC Press

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    Drug discovery for ocular diseases has taken great strides in the last two decades. From cornea to choroid, new drugs have been formulated to address a great variety of ocular diseases. Yet without good drug delivery systems, these drugs are less effective than they might be or could even cause serious side effects. Ocular Drug Delivery Systems: Barriers and Application of Nanoparticulate Systems presents research on the development of currently marketed devices and recent trends in the topical delivery of drugs to the posterior of the eye.

    With contributions from leading pharmaceutical researchers and industry experts, eye researchers, surgeons, pharmacologists from academia, the National Eye Institute, and leading ophthalmic companies such as Pfizer, Allergan, and Novartis, the book presents the state of the art in the use of nanoparticles in ocular drug delivery systems and also sets the stage for future developments.

    This volume provides both a current evaluation and a future roadmap for developments in ocular drug delivery. The subjects range from biological needs to material challenges and finally to clinical applications for improving drug delivery for conditions where treatments already exist. It also explores areas where effective drugs may be currently available but yet need a safe, efficient, and efficacious delivery vehicle.

    Basic Considerations
    Nanoparticle-Based Therapeutics: An Overview
    Deepak Thassu, Kris Holt, and Gerald J. Chader
    Eye Anatomy, Physiology and Ocular Barriers: Basic Considerations for Drug Delivery
    Gerald J. Chader and Deepak Thassu
    Animal Models to Evaluate Ocular Nanoparticular Drug Delivery Systems
    Vinson M. Wang, Jingsheng Tuo, and Chi-Chao Chan
    Computer Modeling for Ocular Drug Delivery
    Paul J. Missel
    Challenges in the Development of Nanotechnology-Based Ophthalmic Systems
    Banu S. Zolnik, Sheriza Baksh, and Nakissa Sadrieh

    Ocular Barriers
    Blood–Retinal Barrier: The Fundamentals
    Rosa Fernandes, Andreia Gonçalves, and José Cunha-Vaz
    Barriers to Transscleral Drug Delivery to the Retina
    Alexandra Almazan, Susan S. Lee, Aron D. Ross, and Michael R. Robinson

    Ocular Compartment Drug Delivery
    Drug Delivery to the Vitreous Humor
    Francine Behar-Cohen
    Transscleral and Suprachoroidal Drug Delivery
    Damian E. Berezovsky and Henry F. Edelhauser
    Protein Drug Delivery to Retina and Choroid
    Hongwen M. Rivers and Patrick M. Hughes
    Transscleral Drug Delivery to the Posterior Segment of the Eye
    Bernard F. Godley, Cheryl L. Rowe-Rendleman, Ed Kraft, and Gabriella Kulp
    Drug Delivery to the Suprachoroidal Space
    Sung Won Cho and Timothy W. Olsen
    Use of Nanoparticles in the Treatment of Age-Related Macular Degeneration, Glaucoma, and Other Degenerative Retinal Diseases
    Marco A. Zarbin, Carlo Montemagno, James F. Leary, and Robert Ritch

    Drug Delivery Systems
    Drug Molecule Characteristics, Drug Delivery Strategies and Their Impact on Ophthalmic Drug Delivery to Anterior versus Posterior Segments
    Kay D. Rittenhouse
    Surface Modulation of Nanoparticles
    Deepak Thassu and Kris Holt
    Nanoparticles for the Treatment of Retinal Diseases
    Amin Famili and Uday B. Kompella
    Gene-Based Medicine for Ocular Diseases
    Shannon M. Conley and Muna I. Naash
    Stealth-Type Polymeric Nanoparticles with Encapsulated Betamethasone Phosphate for Treatment of Intraocular Inflammation
    Tsutomu Sakai, Tsutomu Ishihara, and Megumu Higaki

    Technology and Materials Development
    Nanotechnology-Guided Imaging of Retinal Vascular Disease
    Joshua R. Trantum and Ashwath Jayagopal
    Photoresponsive Polymers for Ocular Drug Delivery
    Laura A. Wells and Heather Sheardown
    Nanosuspensions in Ocular Drug Delivery Systems
    Himanshu Bhattacharjee and Sonia Bedi


    Deepak Thassu is the Vice President of Pharmaceutical Development at Pharmanova, Inc., in Victor, New York.

    Gerald Chader is Chief Scientific Officer of the Doheny Retina Institute at USC Medical School in Los Angeles.