1st Edition
Pharmacokinetic Principles of Dosing Adjustments Understanding the Basics
By Ronald D. Schoenwald
Copyright 2000
270 Pages
by
Routledge
272 Pages
by
Routledge
Also available as eBook on:
This book has evolved over the last twenty years from a cumulative effort to develop a professional course in pharmacokinetics that would assist future practitioners in therapeutic decision making. As practicing pharmacists become more involved with patient advising, it becomes apparent that clinicians will be required to make dosing adjustments for certain drugs. This will become increasingly... Read more
BASIC CONCEPTS
Pharmacokinetic Processes
Introduction
Overview of Pharmacokinetic Processes
Study Guide
Kinetic Processes Applied to the Whole Body
Introduction
Classical Pharmacokinetic Models
Justification for Application of a One-Compartment Model
Study Guide
Disposition Parameters of the One-Compartment Model
Introduction
Elimination Rate Constant
Half-Life
Volume of Distribution
Area Under the Plasma Concentration-Time Curve
Systemic Clearance
Study Guide
Parameters Used In Adjusting Doses
Therapeutic Drug Monitoring and the Retrospective Approach
Prospective Approach
Urine Measurements of Drugs and Renal Clearance
Dosage Adjustment in Renal Failure
Hepatic Elimination and Dosing Adjustments
Study Guide
PARENTERAL DOSING ADJUSTMENTS
Infusion
Introduction
Basic Infusion Principles
Bolus Dose Plus Constant Rate Infusion
Rapid Infusion Followed by Slow Infusion
Intermittent Infusion
Study Guide
ORAL DOSING
Important Parameters
Introduction
Fraction Absorbed (F)
Absorption Rate Constant
Factors Affecting the Absorption of Drugs
Study Guide
Bioavailability/Bioequivalence
Introduction
Definitions
Bioavailability Measurements
Bioequivalence
Generic Substitution
Study Guide
Multiple Dosing Regimens
Introduction
Superposition Principle and Multiple Dosing
Multiple Dosing Factor
Multiple Dosing Equations
Accumulation
Missed Dose
Study Guide
ADVANCED CONSIDERATIONS
Two-Compartment Model
Introduction
Volumes of Distribution
IV Infusion: Two-Compartment Model
Dosing Strategies
Advanced Considerations
Study Guide
An Introduction to Nonlinear Pharmacokinetics
Introduction
Application to Phenytoin Dosing Regimens
Single-Point Method
Bayesian Approach
Study Guide
Appendix: Study Guide Solutions
Index
Pharmacokinetic Processes
Introduction
Overview of Pharmacokinetic Processes
Study Guide
Kinetic Processes Applied to the Whole Body
Introduction
Classical Pharmacokinetic Models
Justification for Application of a One-Compartment Model
Study Guide
Disposition Parameters of the One-Compartment Model
Introduction
Elimination Rate Constant
Half-Life
Volume of Distribution
Area Under the Plasma Concentration-Time Curve
Systemic Clearance
Study Guide
Parameters Used In Adjusting Doses
Therapeutic Drug Monitoring and the Retrospective Approach
Prospective Approach
Urine Measurements of Drugs and Renal Clearance
Dosage Adjustment in Renal Failure
Hepatic Elimination and Dosing Adjustments
Study Guide
PARENTERAL DOSING ADJUSTMENTS
Infusion
Introduction
Basic Infusion Principles
Bolus Dose Plus Constant Rate Infusion
Rapid Infusion Followed by Slow Infusion
Intermittent Infusion
Study Guide
ORAL DOSING
Important Parameters
Introduction
Fraction Absorbed (F)
Absorption Rate Constant
Factors Affecting the Absorption of Drugs
Study Guide
Bioavailability/Bioequivalence
Introduction
Definitions
Bioavailability Measurements
Bioequivalence
Generic Substitution
Study Guide
Multiple Dosing Regimens
Introduction
Superposition Principle and Multiple Dosing
Multiple Dosing Factor
Multiple Dosing Equations
Accumulation
Missed Dose
Study Guide
ADVANCED CONSIDERATIONS
Two-Compartment Model
Introduction
Volumes of Distribution
IV Infusion: Two-Compartment Model
Dosing Strategies
Advanced Considerations
Study Guide
An Introduction to Nonlinear Pharmacokinetics
Introduction
Application to Phenytoin Dosing Regimens
Single-Point Method
Bayesian Approach
Study Guide
Appendix: Study Guide Solutions
Index
Biography
Ronald D. Schoenwald
"...introductory text... With its concise presentation and user-friendly examples, this text would best be utilized in introductory pharmocokinetics courses at the undergraduate level. It would also be a valuable addition to the reference collection of any medical library or drug information center."
-American Journal of Pharmaceutical Education, vol. 65, Fall 2001
