Pharmacokinetic Principles of Dosing Adjustments: Understanding the Basics, 1st Edition (Paperback) book cover

Pharmacokinetic Principles of Dosing Adjustments

Understanding the Basics, 1st Edition

By Ronald D. Schoenwald

Routledge

272 pages

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Paperback: 9781566768993
pub: 2000-11-30
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Description

This book has evolved over the last twenty years from a cumulative effort to develop a professional course in pharmacokinetics that would assist future practitioners in therapeutic decision making. As practicing pharmacists become more involved with patient advising, it becomes apparent that clinicians will be required to make dosing adjustments for certain drugs. This will become increasingly more likely as pharmacy practitioners have access to patient information that requires careful attention to dose and dosing interval, which in turn correlates to various pharmacokinetic parameters such as half-life and the volume of distribution of drugs.

Although many handbooks are available on this subject, they do not devote more than a brief chapter to the concepts behind the dosing adjustment approach. Pharmacokinetic Principles of Dosing Adjustments provides the concepts used to formulate approaches. Equations that appear in various chapters are developed, not through lengthy derivations, but by more of an intuitive approach. The equations are presented in their conceptual form, rather than a separate convenient form applicable to each clinic situation. This method is used to demonstrate how you can apply the initial conditions to the properties of the drug, patient and/or route of administration, rather than memorizing each variation of the basic equation. The author defines pertinent pharmacokinetic terms as well as kinetic processes and classical modeling relevant to dosing adjustments. Examples are included within each chapter that emphasize an understanding of the concepts.

Pharmacokinetic Principles of Dosing Adjustments was written for practitioners who operate in a setting that requires careful consideration to dosing parameters and, in particular, with patients that require constant monitoring of therapeutic outcomes including dosing adjustments. Based on the introductory course in pharmacokinetics taught by Dr. Schoenwald for the past twenty years, this book is intended as a review and resource for practicing pharmacists.

Reviews

"…introductory text… With its concise presentation and user-friendly examples, this text would best be utilized in introductory pharmocokinetics courses at the undergraduate level. It would also be a valuable addition to the reference collection of any medical library or drug information center."

-American Journal of Pharmaceutical Education, vol. 65, Fall 2001

Table of Contents

BASIC CONCEPTS

Pharmacokinetic Processes

Introduction

Overview of Pharmacokinetic Processes

Study Guide

Kinetic Processes Applied to the Whole Body

Introduction

Classical Pharmacokinetic Models

Justification for Application of a One-Compartment Model

Study Guide

Disposition Parameters of the One-Compartment Model

Introduction

Elimination Rate Constant

Half-Life

Volume of Distribution

Area Under the Plasma Concentration-Time Curve

Systemic Clearance

Study Guide

Parameters Used In Adjusting Doses

Therapeutic Drug Monitoring and the Retrospective Approach

Prospective Approach

Urine Measurements of Drugs and Renal Clearance

Dosage Adjustment in Renal Failure

Hepatic Elimination and Dosing Adjustments

Study Guide

PARENTERAL DOSING ADJUSTMENTS

Infusion

Introduction

Basic Infusion Principles

Bolus Dose Plus Constant Rate Infusion

Rapid Infusion Followed by Slow Infusion

Intermittent Infusion

Study Guide

ORAL DOSING

Important Parameters

Introduction

Fraction Absorbed (F)

Absorption Rate Constant

Factors Affecting the Absorption of Drugs

Study Guide

Bioavailability/Bioequivalence

Introduction

Definitions

Bioavailability Measurements

Bioequivalence

Generic Substitution

Study Guide

Multiple Dosing Regimens

Introduction

Superposition Principle and Multiple Dosing

Multiple Dosing Factor

Multiple Dosing Equations

Accumulation

Missed Dose

Study Guide

ADVANCED CONSIDERATIONS

Two-Compartment Model

Introduction

Volumes of Distribution

IV Infusion: Two-Compartment Model

Dosing Strategies

Advanced Considerations

Study Guide

An Introduction to Nonlinear Pharmacokinetics

Introduction

Application to Phenytoin Dosing Regimens

Single-Point Method

Bayesian Approach

Study Guide

Appendix: Study Guide Solutions

Index

About the Series

Pharmacy Education Series

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
MED072000
MEDICAL / Pharmacy