1st Edition
Phytochemicals in the Management of Rheumatoid Arthritis
Section A
Chapter 1: Introduction to chemistry of phytochemicals
Alam Zeb
Chapter 2: Introduction to Rheumatoid arthritis
Mehak Fatima, Ammara Saleem, Justyna Wozniak, Muhammad Furqan Akhtar
Chapter 3: Current pharmacotherapy for Rheumatoid arthritis
Mehak Fatima, Ammara Saleem, Aisha Mobashar, Muhammad Furqan Akhtar
Chapter 4: Combination therapy and dual inhibition of signaling pathways in Rheumatoid arthritis
Tanzeela Awan, Uzma Saher, Justyna Wozniak, Ayesha Fatima, Ammara Saleem
Section B
Chapter 5: Phytochemicals targeting Nuclear factor kappa B and matrix metalloproteinases pathways to treat Rheumatoid arthritis
Hamna Mehmood, Ammara Saleem, Aisha Mobashar, Muhammad Furqan Akhtar, Justyna Wozniak, Joham Javed
Chapter 6: Phytochemicals targeting arachidonic acid pathway to treat Rheumatoid arthritis
Aisha Shehzad, Aqsa Mushtaq , Hafiza Sidra Yaseen, Ammara Saleem
Chapter 7: Phytochemicals targeting JAK/STAT pathway to treat Rheumatoid arthritis
Sara Zahid, Sampath Chinnam, Sana Kashan, Ammara Saleem
Chapter 8: Phytochemicals targeting PI3K/Akt/mTOR signaling pathway to treat Rheumatoid arthritis
Ramla Shabbir, Rukhsar Imran, Shaneel Kousar, Yusuf Tatur, Ammara Saleem
Chapter 9: Phytochemicals targeting transforming growth factor (TGF)-β and Inducible nitric oxide synthase to treat Rheumatoid arthritis
Humaira Gul, Rida Siddique, Muntaha Maqbool, Noor-ul-Eman, Atika Afzal, Faraza Javaid, Yusuf Tatur, Ammara Saleem
Chapter 10: Phytochemicals targeting Vascular endothelial growth factor (VEGF) and RANKL pathway in the treatment of Rheumatoid arthritis
Rida Siddique, Muhammad Asim Shehzad, Rabia Arshad, Ammara Saleem
Chapter 11: Clinical studies about phytomedicines for the management of Rheumatoid arthritis
Atika Afzal, Ayesha Mahmood, Shaneel Kousar, Sajid Ali, Ammara Saleem
Section C
Chapter 12: Phytochemicals as nutraceuticals in the management of Rheumatoid arthritis
Shakila Sabir, Muhammad Naeem, Ammara Saleem, Ghulam Md Ashraf, Muhammad Furqan Akhtar
Chapter 13: Adverse effects of phytochemicals used to treat Rheumatoid arthritis
Shakila Sabir, Muhammad Ejaz-ul-Haq, Ammara Saleem, Syed Haroon Khalid, Muhammad Furqan Akhtar
Section D
Chapter 14: Novel pharmaceutical dosage forms of Phytochemicals for the treatment of Rheumatoid arthritis
Samia Gul Niazi, Mahdia Arshad, Chanda Javed, Shahida Shaeen, Anil Ahsan, Muhammad Furqan Akhtar, Ammara Saleem
Chapter 15: Photodynamic therapy using photoactive phytochemicals
Maria Tahir, Ammara Saleem, Qadeer Ahmad, Muhammad Furqan Akhtar, Mirza Muhammad Faran Ashraf Baig, Muhammad Imran Khan
Chapter 16: Pharmaceutical and regulatory considerations, and future prospective of Phytomedicines and nutraceuticals
Ejaz Basheer, Shahid Rasool, Muhammad Talha, Muhammad Najeeb Ullah, Ammara Saleem, Mhammad Furqan Akhtar
Biography
Dr. Ammara Saleem is the Assistant Professor, Department of Pharmacology, Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, Pakistan. She has published more than 117 research papers in renowned journals with impact factor more than 440. She has 11 years of teaching and research experience. Her specific research area is inflammatory diseases, metabolic disorders, neurological and immunological disorders. She has published various research articles regarding medicinal plants for the treatment of inflammatory and immune disorders. She is the editorial board member in BioMed research international journal and Canadian respiratory journal. She has reviewed for different well reputed international scientific journals such as Molecules, Food, Frontier in Pharmacology etc.
Dr. Muhammad Furqan Akhtar is the Associate Professor, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Pakistan.
He has fourteen years of teaching and research experience. He is the author of more than 150 peer reviewed ISI-indexed articles with a cumulative impact factor of 500. He has supervised more than 49 post-graduate pharmacology students and is serving as academic/Associate editor of several prestigious international journals such as international journal of Endocrinology, Plos One. Evidence based complementary and alternative medicine, Frontier in Pharmacology, Heliyon. His research work focusses on pre-clinical exploration of neurological, endocrine, metabolic and immune diseases such as infertility, polycystic ovarian syndrome, obesity, drug induced infertility, diabetes and arthritis by drug-repurposing, nutraceuticals and, natural and synthetic drugs in animal models of disease and in-vitro methods. More specifically, he carries out research to investigate the role of potential drugs in ameliorating oxidative stress, genotoxicity and inflammation through a range of molecular and biochemical techniques so as to elucidate their mechanism of action. At larger scales, He is interested in the treatment of neurological and endocrine diseases, immune-stimulation as well as phytomedicines and ethnopharmacology. He also investigates the potential health hazardous effects, especially genotoxicity, endocrine disruption and neuro-degenerative diseases associated with the environmental pollutants such as microplastics and herbicides, so as to develop strategies to overcome these problems. Through these studies, he has investigated, compared and corroborated a range of nutraceuticals, herbal remedies and repurposed drugs for the management of various chronic ailments.
Dr. Alam Zeb is a Professor of Biochemistry. He currently works in The Bioactive Lab, Center for Desert Agriculture, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. He worked for 21 years at the Department of Biochemistry, University of Malakand, Pakistan. He is serving for 22 years at the same university teaching chemistry and biochemistry courses to undergraduate, graduate and postgraduate students of biotechnology and biochemistry. Dr. Zeb has received his PhD with distinction from the Institute of Biochemistry, Technical University of Graz, Austria. Dr. Zeb published more than 109 research articles regarding the subject in various international peer-reviewed journals. Dr. Zeb had authored two books, the recent one is a textbook “Phenolic antioxidants in Foods: Chemistry, Biochemistry and Analysis” published by Springer Nature, Switzerland in 2021. The second textbook “Food Frying: Chemistry, Biochemistry and Safety” had been published by John Wiley and Sons, UK, in 2019. This book has been ranked 4th among the best top 10 books of all times in the field of chemistry and safety by Bookauthority.org. He had supervised several PhD and MPhil research students during his service at the University of Malakand. He is a member of the editorial board of several international journals including Frontiers in Nutrition, Journal of Food Processing and Preservation, and Current Functional Foods. Dr. Zeb is a productive scientist of Pakistan since 2009 and had received research productivity awards from Pakistan Council for Science and Technology, Pakistan, for several consecutive years, representing his contribution in the field of biochemistry.
