1st Edition

Programmed Cell Death in Animals and Plants

Edited By John Bryant, Jeff Garland, S.G. Hughes Copyright 2000
    328 Pages
    by Garland Science

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    This title, the 52nd in symposium series, presents a comprehensive review of apoptosis and features contributions from many internationally recognised authors. The book is the first to integrate programmed cell death in plants, invertebrates and vertebrates. Rapid publication ensures that the very latest research is included.

    Contributors -- Abbreviations -- Preface -- 1 Apoptotic cell death: from worms to wombats ... but what about the weeds? 1 /M.O. Hengartnerand J.A. Bryant -- Caenorhabditis elegans: the worm that turned ... into a model multicellular eukaryote -- The molecular mechanisms of programmed cell death in Caenorhabditis elegans -- Comparison with mammalian apoptosis -- Plants, from Arabidopsis to Zinnia -- General conclusions -- 2 Caspases - at the cutting edge of cell death /H.R. Stennicke -- Introduction -- Caspases and their properties -- Structure of the caspases -- Activation and regulation of the caspases -- Evolution of the caspases -- 3 Modulation of death receptor signalling /P. Schneider and J.Tschopp -- Introduction -- Death receptors and apoptosis -- Activation of death receptors by death ligands -- Decoy receptors -- Inhibition of death receptor by FLIP -- Conclusion -- 4 The role of the Bcl-2 family in the modulation of apoptosis /C. Pepper and P. Bentley -- Introduction -- Bcl-2 family: life or death promoters -- Function of the Bcl-2 family proteins -- Cellular control of Bcl-2 family proteins -- Over-expression of Bcl-2 family proteins and chemoresistance -- Drug resistance in B-CLL -- Strategies for inhibiting Bcl-2 function in B-CLL -- Conclusions -- 5 The role of granzymes and serpins in regulating cell growth and death /P. Coughlin, E. Morris and L. Hampson -- Introduction -- Induction of apoptosis by cytotoxic T cells and natural killer cells -- How does granzyme B gain access to the interior of target cells? -- Molecular targets of granzyme B -- Regulation of granzyme B activity -- The intracellular regulation of granzyme B by PI-9 -- The role of intracellular serpins in cell growth and death -- Conclusions -- 6 Mitochondria and cell death: a pore way to die? /A.P. Halestrap, J.P. Gillespie, A. O'Toole and E. Doran -- Introduction -- The mitochondrial permeability transition -- Mitochondria and apoptosis -- 7 Regulation of apoptosis by cell metabolism


    School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK. School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK. School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK.

    'This will be an excellent reference source for the expert.' - Aslib Book Guide

    'The book provides an excellent overview of the burgeoning field of apoptosis. It is a superb reference for basic scientists or anyone interested in this fast growing research area that shows no sign of apoptotic shrinkage in the near future.' - The Quarterly Review of Biology