This book provides an updated overview of eicosanoid metabolism. It also presents a timely discussion of eicosanoid metabolism in the process of tumor cell metastasis, in chemoprotection and radioprotection associated with cancer therapy, and in cell differentiation. The book focuses on the role of eicosanoids in the immunology of malignant disease. This includes how various immune cell populations in cancer are affected by the secretion and action of various eicosanoids and metabolites of eicosanoids and how these processes may be affected by various pharmacological manipulations and interventions to augment anti-tumor immunity. Head and neck cancer is covered in great detail to illustrate a cancer in humans where these considerations are particularly relevant. This important volume demonstrates that the principal factor in cancer patient immunologic deficiency is related to excess secretion by monocytes of prostaglandins.
Cyclooxygenase and Lipoxygenase Pathways of Arachidonic Acid Metabolism (W.L. Smith and O. Laneuville). Participation of Lipoxygenase Products in Lymphohematopoietic and Other Cell Proliferation and Differentiation (K.M. Anderson, M. Wiederhold, and F. Ondrey). Eicosanoids and Tumor Cell Metastasis (D.G. Tang and K.V. Honn). The Impact of Prostaglandins on Cancer Patient Immunity (D.P. Braun and J.E. Harris). Prostaglandins and Host Immune Response in Squamous Cell Carcinoma of the Head and Neck (D.S. Cross, F. Ondrey, S.K. Juhn, and G.L. Adams). Eicosanoid-Induced Radioprotection and Chemoprevention of Normal Tissue During Cancer Treatment (W.R. Hanson). Prostaglandins and the Host Immune System: Application of Prostaglandin Inhibitors for Cancer Immunotherapy (P.K. Lala and M.-N. Saarloos).