1st Edition

Proteoglycans in Lung Disease




ISBN 9780824708153
Published October 16, 2002 by CRC Press
480 Pages

USD $200.00

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Book Description

Discusses new treatment strategies for malignant mesothelioma, pulmonary edema, fibrosis, asthma, emphysema, and bronchiectasis.

Proteoglycans in Lung Disease considers

  • glycosaminoglycans as novel therapeutic agents or targets in lung disease
  • the role of proteoglycans in determining mechanical behavior of lung tissue
  • hyaluronan and its receptors in wound healing, inflammation, vasculogenesis, and angiogenesis
  • the impact of small proteoglycans on matrix assembly
  • versican as a modulator of cell adhesion, migration, and proliferation
  • antiproliferative activity of heparin and its derivatives on pulmonary artery smooth muscle cells
  • the effects of mechanical strain on proteoglycans
  • the functions of proteoglycans in the vascular wall
  • the effect of hypoxia on glycosaminoglycans in the lung
    Comprised of more than 1940 references, Proteoglycans in Lung Disease
  • Table of Contents

    Proteoglycans of the Lung
    Peter J. Roughley
    Hyaluronan in Lung Function: An Overview
    Paul W. Noble
    Morphological Tools for Studying Lung Proteoglycans
    Paulo Sampaio Guitierrez and Vera Demarchi Aiello
    Proteoglycans, Lung Physiology, and Mechanical Strain
    Mara S. Ludwig
    Hyaluronan and Its Receptors in Lung Health and Disease
    Rashmin C. Savani and Horace M. Delisser
    Hyaluronan and Hyaladherin Signaling in the Lung
    Sara Hamilton, Eva A. Turley, and Fu-Sheng Wang
    Hyaluronan in Malignant Mesothelioma
    Anders L. Thylén and Gunnar Martensson
    Matrix Proteoglycans in Development of Pulmonary Edema
    Daniela Negrini, Alberto Passi, Giancarlo de Luca, and Giuseppe Miserocchi
    The Role of Small Proteoglycans in the Formation of Fribrosis
    Gunilla Westergren-Thorsson, Ellen Tufvesson, Erik Eklund, and Anders Malmstrom
    Versican in the Cell Biology of Pulmonary Fibrosis
    Clive R. Roberts
    Decorin in Asthma
    Anthony E. Redington
    Role of Proteoglycans in the Development and Pathogenesis of Emphysema
    Ymke M. Van Der Geld, Jeanette F. M. Van Straaten, Dirkje S. Postma, and Wim Timens
    Proteoglycans in Normal and Pathological Bronchial Mucus
    K. Ramakrishnan Bhaskar
    Vascular Proteoglycans
    Hannu Järveläinen and Thomas N. Wight
    Degradation of Lung Matrix Proteoglycans in Bronchiectasis
    Daisy Kwok Yan Shum and Mary Sau Man Ip
    Effect of Hypoxia on Glycosaminoglycan Synthesis by Lung Cells
    Eleni Papakonstantinou and George Karakiulakis and Michael Roth
    Integrins, Proteoglycans, and Lung Disease
    Jiahua Xu
    Heparin as a Potential Therapeutic Agent to Reverse Vascular Remodeling
    Hari G. Garg, Charles A. Hales, and Robert J. Linhardt

    Author Index
    Subject Index

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