1st Edition

Proteostasis and Proteolysis

Edited By Niki Chondrogianni, Elah Pick, Anna Gioran Copyright 2022
    267 Pages 25 Color & 28 B/W Illustrations
    by CRC Press

    267 Pages 25 Color & 28 B/W Illustrations
    by CRC Press

    267 Pages 25 Color & 28 B/W Illustrations
    by CRC Press

    Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.

    Chapter 2 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution-Non Commercial-No Derivatives (CC-BY-NC-ND) 4.0 license. 



    The Editors

    1. Ribosomal Pauses during Translation and Proteostasis

    Alejandro Ferrando, Alihamze Fathinajafabadi, Arantxa Martínez- Férriz and Rosa Farràs

    2. Protein Folding and Misfolding: Deciphering Mechanisms of Age-Related Diseases

    Judith-Elisabeth Riemer, Diana Panfilova, Heidi Olzscha

    3. Transcriptional Regulation of Proteostatic Mechanisms

    Marianna Kapetanou, Sophia Athanasopoulou, Efstathios S. Gonos

    4. MicroRNAs as Central Regulators of Adult Myogenesis and Proteostasis Loss in Skeletal Muscle Aging

    Ioannis Kanakis, Ioanna Myrtziou, Aphrodite Vasilaki, Katarzyna Goljanek-Whysall

    5. mRNA Granules and Proteostasis in Aging and Age-Related Diseases

    Fivos Borbolis and Popi Syntichaki

    6. Phospholipids and the Unfolded Protein Response

    Ilias Gkikas and Nektarios Tavernarakis

    7. Ubiquitin Ligases Involved in Progeroid Syndromes and Age-Associated Pathologies

    Lisa Fechtner and Thorsten Pfirrmann

    8. Role of SUMOylation in Neurodegenerative Diseases and Inflammation

    Esmeralda Parra-Peralbo, Veronica Muratore, Orhi Barroso-Gomila, Ana Talamillo, James D. Sutherland and Rosa Barrio

    9. NEDD8 and Oxidative Stress

    Elah Pick and Giovanna Serino

    10. Structure, Function and Regulators of the 20S Proteasome

    Tobias Jung and Annika Höhn

    11. Cellular Responses to Proteasome Impairment

    Maja Studencka-Turski and Elke Krüger

    12. Proteasome Fate in Aging and Proteinopathies

    Mary A. Vasilopoulou, Nikoletta Papaevgeniou and Niki Chondrogianni

    13. The Proteasomal System in Cancer

    Sema Arslan-Eseryel, Ulkugul Guven and Betul Karademir-Yilmaz

    14. Proteostasis and Skin Aging

    Anne-Laure Bulteau and Bertrand Friguet

    15. Reactive Oxygen Species and Protein Homeostasis in Skeletal Muscle Regeneration

    Sofia Lourenço dos Santos, Aurore L’Honoré and Isabelle Petropoulos

    16. Protein Degradation in Cardiac Health and Disease

    Xuejun Wang

    17. Autophagy in Aging and Oxidative Stress

    Dimitra Ranti, Anna Gioran and Niki Chondrogianni

    18. Autophagy in Aging and Longevity Exemplified by the Aging Heart

    Steffen Häseli and Christiane Ott



    Niki Chondrogianni

    Research areas: Ageing, longevity, age-related diseases, proteolysis, proteasome, redox regulation, cellular senescence, C. elegans

    Dr. Chondrogianni graduated and obtained her PhD from the Department of Biology of the National and Kapodistrian University of Athens in Greece, while she was a visiting fellow at the Universities Paris 7 in France and Bristol in UK. She conducted her post-doctoral studies at the National Hellenic Research Foundation (NHRF) in Athens focusing on the role of proteasome activation on cellular and organismal lifespan extension. She was trained in the use of C. elegans at the Foundation of Research and Technology-Hellas, Institute of Molecular Biology and Biotechnology in Greece. She established her lab at NHRF in 2009. She focuses on the genetic and environmental factors that govern ageing, longevity and age-related diseases with emphasis on proteasome regulation. She is seeking for natural or chemically-synthesized compounds that may act as proteasome activators and thus may serve as anti-ageing agents and/or as anti-aggregation compounds that can decelerate the progression of various proteinopathies with emphasis on Alzheimer’s disease.

    Elah Pick

    Research areas: Cell biology, protein biochemistry, proteolysis, redox, the ubiquitin proteasome system

    Prof. Elah Pick performed her graduate and postdoctoral training in cell Biochemistry, membrane traffic and protein degradation at the Technion – Israel Institute of Technology. She performed a second postdoctoral training at Yale university on a family of genes that regulate the molecular and biochemical mechanisms responsible for cellular responses to external stimuli and stresses. She established her own lab in Israel, at the department for Biology and Environment of the University of Haifa, located at Oranim. Her lab investigates the effect of metabolic and environmental stresses such as oxidation, on the regulation of protein degradation.

    Anna Gioran

    Research areas: Mitochondria, neurobiology, metabolism proteostatic mechanisms, C. elegans

    Dr. Anna Gioran carried out her graduate training at the German Center of Neurodegenerative Diseases (DZNE) in Bonn, Germany. During this time, she studied the effects of mitochondrial deficiency on the morphology of the nematode’s neurons. In her first postdoctoral fellowship she continued at the DZNE and she focused more on mitochondrial deficiencies and specifically on their metabolic implications and manners to rescue its detrimental effects at organismal level. At the time this book was written, she was conducting her second postdoctoral research under the supervision of Dr. Niki Chondrogianni at the National Hellenic Research Foundation in Athens, Greece, focusing on the interplay between proteostatic mechanisms and mitochondrial function.