Rational Basis for Clinical Translation in Stroke Therapy

Stroke Units, Regional Systems of Emergency Stroke Care, and Telestroke Networks; Anna Cavallini, Elisa Candeloro, Alessandra Persico, Isabella Canavero, and Giuseppe Micieli

Overview of Endovascular Treatment and Revascularization Strategies in Acute Ischemic Stroke; Salvatore Mangiafico and Arturo Consoli

Benefits and Harms of Pharmacological Thrombolysis; Svetlana Lorenzano and Danilo Toni

Mechanical Revascularization Strategies for Stroke Treatment; Erasmia Broussalis and Monika Killer

Risk Factors and Restroke Prevention; Vida Demarin, Sandra Morovic, and Tatjana Rundek

Genomics for the Advancement of Clinical Translation in Stroke; Steven D. Brooks, Reyna Van Gilder, Jefferson C. Frisbee, and Taura L. Barr

Acute Stroke Imaging and Beyond; Nicoletta Anzalone, Corrado Santarosa, and Costantino De Filippis

Imaging the Penumbra: CTP or Perfusion–Diffusion MRI Mismatch?; Alessandro Bozzao, Alessandro Boellis, and Andrea Romano

Predictors of Hemorrhagic Transformation of Ischemic Stroke after Thrombolysis; Domenico Inzitari, Francesco Arba, Benedetta Piccardi, and Anna Poggesi

Imaging Approaches to Map the Penumbra in Preclinical Stroke Models; Phillip Zhe Sun, Yu Wang, Xunming Ji, and Eng H. Lo

Trial Design and Reporting Standards for Acute Intravascular Cerebral Thrombolysis; Gregory J. del Zoppo and Alfonso Ciccone

Analysis and Interpretation of Outcome Measures in Stroke Clinical Trials; Stefano Ricci

Evaluation of Interventions in Stroke: The Cochrane Stroke Group Experience; Peter Langhorne

Neuroprotective Therapy: Failure and Future for Clinical Application; Taizen Nakase

Stroke Model Guidelines and STAIR Recommendations for Preclinical Stroke Studies; Shimin Liu

Animal Models of t-PA-Induced Hemorrhagic Transformation; Isaac García-Yébenes, Victor G. Romera, Macarena Hernández-Jiménez, Guadalupe Camarero, Tamara Atanes, Ignacio Lizasoain, and María A. Moro

Assessment of Sensorimotor Symptoms in Rodents after Experimental Brain Ischemia; Juan G. Zarruk, Jesús M. Pradillo, María J. Alfaro, Roberto Cañadas, María A. Moro, and Ignacio Lizasoain Section

Glutamate and Stroke: From NMDA to mGlu Receptors and Beyond; Tania Scartabelli, Elisa Landucci, Elisabetta Gerace, and Domenico E. Pellegrini-Giampietro

Therapeutic Hypothermia for Acute Stroke; Serena Candela, Michele Cavallari, and Francesco Orzi

Drug-Induced Hypothermia in Stroke: Current Status and New Therapeutic Approaches; Mirko Muzzi and Alberto Chiarugi

Immune Response in Cerebral Ischemia: Role of TLRs; Jesús M. Pradillo, Ana Moraga, Alicia Garcia-Culebras, Sara Palma-Tortosa, Marta Oses, Diana Amantea, María A. Moro, and Ignacio Lizasoain

Polarization of Macrophages/Microglia toward an M2 Phenotype as a Therapeutic Strategy for Stroke Treatment; Iván Ballesteros, María I. Cuartero, Juan de la Parra, Alberto Pérez-Ruiz, Olivia Hurtado, Ignacio Lizasoain, and María A. Moro

Minocycline Repurposing for Acute Cerebral Hemorrhage; Jeffrey A. Switzer, Andrea N. Sikora, David C. Hess, and Susan C. Fagan

NCX as a Key Player in the Neuroprotection Exerted by Ischemic Preconditioning and Postconditioning; Giuseppe Pignataro, Ornella Cuomo, Antonio Vinciguerra, Pierpaolo Cerullo, Gianfranco Di Renzo, and Lucio Annunziato

Cell-Based Therapies for Stroke; Paul M. George and Gary K. Steinberg

Contribution of Neuroplasticity to Recovery after Stroke; Nikhil Sharma

Stroke Rehabilitation Care: Management and Procedures; Michelangelo Bartolo, Chiara Zucchella, and Giorgio Sandrini

Focal Treatment of Stroke-Related Spasticity in the Rehabilitation Setting: Clinical Exploitation of Botulinum Toxin; Sheila Catani and Alessandro Clemenzi

Use of Antidepressants as Adjunctive Therapy to Improve Recovery after Ischemic Stroke; Harold P. Adams, Jr.

Index

Biography

Giuseppe Micieli is director of the Department of Emergency Neurology at the IRCCS "C. Mondino" Foundation in Pavia, Italy, as well as adjunct professor at the University of Pavia. He received his degree in medicine and surgery from the University of Pavia and holds specialization degrees in neurology and clinical pharmacology. He is former director of the Laboratory of Vegetative Physiopathology, the Headache Centre, and the Sub-intensive Unit of Cerebrovascular Diseases at the IRCCS "C. Mondino" Foundation. He is also the former leader of the Emergency Neurology and Stroke Unit of the Humanitas Clinical Institute in Rozzano, Milan. Dr. Micieli has published more than 170 peer-reviewed articles and held numerous leadership positions including coordinating roles for the Stroke Unit Network and the Italian Stroke Forum.

Diana Amantea is aggregate professor of pharmacology in the Department of Pharmacy, Health Sciences and Nutrition at the University of Calabria, Italy. She also leads the Stroke Research Unit at the Center of Preclinical and Translational Pharmacology located in the University of Calabria. Dr. Amantea received her PharmD from the University of Calabria and her PhD in pharmacology from the University of Birmingham. Her research focuses on understanding the inflammatory mechanisms occurring during ischemic brain injury in order to identify novel pharmacological targets for stroke therapy.