New contexts are needed for the discussion and integration of basic and clinical data in order to translate the dynamic progress in the field of neuroscience into more effective therapies and patients' health improvements.
The Frontiers in Neurotherapeutics Series provides a multidisciplinary platform to discuss innovative, methodological, and pharmacological approaches aimed at the identification and validation of novel neurotherapeutics. It features reviews and original articles from basic and translational research on cutting-edge topics in diverse and integrated areas of neuroscience, including neuro-immunology and neuro-oncology.
Naturally Occurring Benzodiazepines, Endozepines, and their Receptors Implications for Benzodiazepine Therapy and Withdrawal
Mapping of Nervous System Diseases via MicroRNAs
By Robert B. Raffa, Diana Amantea
August 13, 2021
Understanding and addressing the current opioid crisis requires knowledge of endogenous opioids (endorphins and enkephalins), but there is now evidence for a benzodiazepine crisis. Are there endogenous benzodiazepine-like substances—and what do they do? How do they affect antianxiety drugs and ...
By Giuseppe Micieli, Diana Amantea
September 18, 2018
Stroke remains one of the major causes of death and long-term disability worldwide. Currently, the only approved therapy for the acute treatment of this disease is thrombolysis, a strategy that can only be applied to a small percentage of patients due to its narrow therapeutic window. Unfortunately...
By Joel Dudley, Laura Berliocchi
June 30, 2017
Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet. In the last decades, traditional R...
By Christian Barbato, Francesca Ruberti
January 27, 2016
In recent years, understanding of microRNA (miRNA) biogenesis, the molecular mechanisms by which miRNAs regulate gene expression, and the functional roles of miRNAs has expanded. Mapping of Nervous System Diseases via MicroRNAs provides an up-to-date review on the function of miRNA in neurological ...