This book brings together the proceedings of Alzheimer's and Parkinson's Diseases: New Perspectives, the Sixth International Conference on Alzheimer's Disease and Parkinson's Disease, held recently in Seville, Spain, and discusses the latest developments in the basic science and therapy of Alzheimer's and Parkinson's diseases by leading specialists on the topic.
Areas discussed include: mechanisms of degeneration of Parkinson's Disease; the interrelationships between gait and cognitive function; advances in gene transfer and pharmacological regulation of protein aggregation in the treatment of Alzheimer's and Parkinson's Diseases; Alzheimer pathology and ER stress; and stem cell strategies for Alzheimer's Disease.
Table of Contents
Mechanisms of Degeneration of Parkinson's Disease. Underlying Biochemical and Molecular Mechanisms of Dyskinesia.
Molecular Neuropathology of Parkinsonism. Familial PD Mutations Affect the Ability of Catecholaminergic Neurons to Withstand Proteasome Inhibition. AChE, Cholinergic Signalling, and Parkinson's Disease. Bone Marrow Stem Cells: Possible Source for Cell Therapy in Parkinson's Disease. Insulin-Like Growth Factor I (IGF-I) and Intracellular Signal Transduction Pathways in Aging and Dementia. The Interrelationships Between Gait and Cognitive Function. Advances in Gene Transfer and Pharmacological Regulation of Protein Aggregation in the Treatment of Alzheimer's and Parkinson's Diseases. Two Parent Proteins That Display Similar Anti-apoptotic Phenotypes But Distinct Responses to 6 - Hydroxydopamine - Induced Toxicity.
Functional Genomics and Pharmacogenetics in Alzheimer Disease. The Genetics of Tau and Neurodegenerative Disease. Amyloid Plaques and Neurofibrillary Tangles in a Triple Transgenic Model: Qualitative Similarities With Human Alzheimer's Neuropathology. Apolipoprotein E and Alzheimer's Disease: What Has a Decade Told Us? Comparison of the Effects of ApoE4 on Presynaptic and Cytoskeletal Plasticity Following Environmental Stimulation. Cholesterol and Amyloid ??Cascade: Pathological Implications of Apolipoprotein E in Alzheimer's Disease. Brain Inflammation and Psychogeriatric Disease. Neuroinflammatory Mechanisms are Involved in the Early Steps of the Pathological Cascade in Alzheimer's Disease. Vascular Nitric Oxide: A Key Molecule in Alzheimer's Disease Pathogenesis. Alzheimer Pathology and ER Stress. Molecular Mechanism of Amyloid ??Peptide - Induced Impairment of Neurotransmission and Memory in Relation to Oxidative Stress.Regulating Factors for Microglial Activation: Implication for Alzheimer Disease and Brain Damage.CSF Phosphorylated Tau Protein at Serine 199 is a Useful Diagnostic Biomarker in Alzheimer's Disease and Mild Cognitive Impairment. Stem Cell Strategies for Alzheimer's Disease. Can Mild Cognitive Impairment Predict Alzheimer's Disease? Lack of Effect of Certoparin in P301L Mutant Tau Pathology.Heparin - Derived Oligosaccharides as Potential Therapeutic Agents in Senile Dementia and Stroke. Human Prion Diseases.
Israel Hanin, PhD, is Professor and Chairman, Department of Pharmacology and Experimental Therapeutics, Loyola University Medical Center, Maywood, Illinois, USA
Ramon Cacabelos, MD, PhD, DMSci, is President and Chief Executive Officer, EuroEspes, Santa Maria de Babio, La Coruña, Spain.
Abraham Fisher, PhD, is Chief Scientists, Israeli Institute for Biological Research, Ness-Ziona, Israel.