1st Edition

Resveratrol in Health and Disease

ISBN 9780849333712
Published November 1, 2005 by CRC Press
712 Pages 70 B/W Illustrations

USD $315.00

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Book Description

Practicing evidenced-based medicine some 25 centuries ago, Hippocrates proclaimed "Let food be thy medicine and medicine be thy food." This advice parallels the common American saying, "You are what you eat," and is supported by a National Institute of Health recommendation to consume as many as eight servings of fruits and vegetables daily to prevent common diseases.

One of the most therapeutically significant components found in food is the polyphenol resveratrol. First described in Ayurvedic medicine 5000 years ago as a cardiotonic, resveratrol is found in several fruits and vegetables including grapes, peanuts, cranberries, blueberries, mulberries, and jackfruit. A favorite and rich source of resveratrol is red wine.

Resveratrol in Health and Disease draws on the expertise of an international panel, representing a cross-section of nutrition-related disciplines, to examine the effects and properties of this legendary nutrient. It explores research that examines a wide range of purported healing and preventive powers:

  • Cardioprotective agent
  • Antitumor agent
  • Angiogenesis inhibitor
  • Antioxidant
  • Radioprotective agent
  • Phytoestrogen source
  • Antifungal and antibacterial agent
  • Neuroprotective agent
  • Modulator of immune system
  • Anti-inflammatory agent

    Reviewing recent literature, these pages explore the pharmacokinetics and metabolism of resveratrol, consider its molecular targets, and look at its role in modulating gene expression, as well as its impact on the mechanism of apoptosis and cell signaling pathways.

    Considering the prohibitive costs of modern medicine, the need for readily available products that are safe and efficacious is critical. Consequently, Resveratrol in Health and Disease may well find its own place in history by providing scientists, clinicians, herbalogists, naturopaths, and those they serve, with the first c

  • Table of Contents

    Resveratrol: A Polyphenol for All Seasons: Shishir Shishodia and Bharat B. Aggarwal
    Sources and Chemistry of Resveratrol: Navindra P. Seeram, Vishal V. Kulkarni, and Subhash Padhye
    Resveratrol as an Antioxidant: Catalina Alarcón de la Lastra, Isabel Villegas, and Antonio Ramón Martín
    Resveratrol as an Antiproliferative Agent for Cancer: Paola Signorelli and Riccardo Ghidoni
    Mechanism of Apoptosis by Resveratrol: Shazib Pervaiz and Andrea Lisa Holme
    Resveratrol as Inhibitor of Cell Survival Signal Transduction: Simone Fulda and Klaus-Michael Debatin
    Resveratrol as Inhibitor of Cell Cycle Progression: Jen-Kun Lin
    Molecular Targets of Resveratrol: Implications to Health and Disease Prevention: Catherine A. O'Brian and Feng Chu
    Resveratrol as an Angiogenesis Inhibitor: Ebba Bråkenhielm, Renhai Cao, and Yihai Cao
    Resveratrol Modulation of Gene Expression: The Role of Transcription Factors: Fulvio Della Ragione, Valeria Cucciolla, Adriana Borriello, and Vincenzo Zappia
    Modulation of Gene Expression by Resveratrol: Bhagavathi A. Narayanan and Narayanan K. Narayanan
    Resveratrol and Prostaglandin Biosynthesis: Lawrence M. Szewczuk and Trevor M. Penning
    Resveratrol as an Inhibitor of Carcinogenesis : John M. Pezzuto
    Resveratrol as an Antitumor Agent In Vivo: Francis Raul
    Resveratrol as a Sensitizer to Apoptosis-Inducing Stimuli: Ali R. Jazirehi and Benjamin Bonavida
    Resveratrol as a Radio-Protective Agent: Yogeshwer Shukla, Shannon Reagan-Shaw, and Nihal Ahmad
    Resveratrol as a Phytoestrogen: Barry D. Gehm and Anait S. Levenson
    Resveratrol as an Antibacterial Agent: Gail B. Mahady
    Resveratrol as an Antifungal Agent: Marielle Adrian and Philippe Jeandet
    Protective Effects of Resveratrol in Age-Related Neurodegenerative Diseases and Gene Regulatory Action: Sofiyan Saleem, Abdullah Shafique Ahmad, and Sylvain Doré
    Protective Effects of Resveratrol against Ischemia-Reperfusion: Dipak K. Das
    Resveratrol as Cardioprotective Agent: Evidence from Bench and Bedside: Sukesh Burjonroppa and Ken Fujise
    Immunomodulation by Resveratrol: Subhash C. Gautam, Xiaohua Gao, and Scott A. Dulchavsky
    Biological Effects of Cis-Versus Trans-Resveratrol: Francisco Orallo
    Resveratrol as an Antiinflammatory Agent: Young-Joon Surh and Joydeb Kumar Kundu
    Neuroprotective Effects of Resveratrol: Ying-Shan Han, Stéphane Bastianetto, and Rémi Quirion
    Pharmacokinetics and Metabolism of Resveratrol: Alberto A. E. Bertelli

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    Aggarwal, Bharat B.; Shishodia, Shishir