Practicing evidenced-based medicine some 25 centuries ago, Hippocrates proclaimed "Let food be thy medicine and medicine be thy food." This advice parallels the common American saying, "You are what you eat," and is supported by a National Institute of Health recommendation to consume as many as eight servings of fruits and vegetables daily to prevent common diseases.
One of the most therapeutically significant components found in food is the polyphenol resveratrol. First described in Ayurvedic medicine 5000 years ago as a cardiotonic, resveratrol is found in several fruits and vegetables including grapes, peanuts, cranberries, blueberries, mulberries, and jackfruit. A favorite and rich source of resveratrol is red wine.
Resveratrol in Health and Disease draws on the expertise of an international panel, representing a cross-section of nutrition-related disciplines, to examine the effects and properties of this legendary nutrient. It explores research that examines a wide range of purported healing and preventive powers:
Reviewing recent literature, these pages explore the pharmacokinetics and metabolism of resveratrol, consider its molecular targets, and look at its role in modulating gene expression, as well as its impact on the mechanism of apoptosis and cell signaling pathways.
Considering the prohibitive costs of modern medicine, the need for readily available products that are safe and efficacious is critical. Consequently, Resveratrol in Health and Disease may well find its own place in history by providing scientists, clinicians, herbalogists, naturopaths, and those they serve, with the first comprehensive overview of this long-lauded tonic.
Resveratrol: A Polyphenol for All Seasons: Shishir Shishodia and Bharat B. Aggarwal
Sources and Chemistry of Resveratrol: Navindra P. Seeram, Vishal V. Kulkarni, and Subhash Padhye
Resveratrol as an Antioxidant: Catalina Alarcón de la Lastra, Isabel Villegas, and Antonio Ramón Martín
Resveratrol as an Antiproliferative Agent for Cancer: Paola Signorelli and Riccardo Ghidoni
Mechanism of Apoptosis by Resveratrol: Shazib Pervaiz and Andrea Lisa Holme
Resveratrol as Inhibitor of Cell Survival Signal Transduction: Simone Fulda and Klaus-Michael Debatin
Resveratrol as Inhibitor of Cell Cycle Progression: Jen-Kun Lin
Molecular Targets of Resveratrol: Implications to Health and Disease Prevention: Catherine A. O'Brian and Feng Chu
Resveratrol as an Angiogenesis Inhibitor: Ebba Bråkenhielm, Renhai Cao, and Yihai Cao
Resveratrol Modulation of Gene Expression: The Role of Transcription Factors: Fulvio Della Ragione, Valeria Cucciolla, Adriana Borriello, and Vincenzo Zappia
Modulation of Gene Expression by Resveratrol: Bhagavathi A. Narayanan and Narayanan K. Narayanan
Resveratrol and Prostaglandin Biosynthesis: Lawrence M. Szewczuk and Trevor M. Penning
Resveratrol as an Inhibitor of Carcinogenesis : John M. Pezzuto
Resveratrol as an Antitumor Agent In Vivo: Francis Raul
Resveratrol as a Sensitizer to Apoptosis-Inducing Stimuli: Ali R. Jazirehi and Benjamin Bonavida
Resveratrol as a Radio-Protective Agent: Yogeshwer Shukla, Shannon Reagan-Shaw, and Nihal Ahmad
Resveratrol as a Phytoestrogen: Barry D. Gehm and Anait S. Levenson
Resveratrol as an Antibacterial Agent: Gail B. Mahady
Resveratrol as an Antifungal Agent: Marielle Adrian and Philippe Jeandet
Protective Effects of Resveratrol in Age-Related Neurodegenerative Diseases and Gene Regulatory Action: Sofiyan Saleem, Abdullah Shafique Ahmad, and Sylvain Doré
Protective Effects of Resveratrol against Ischemia-Reperfusion: Dipak K. Das
Resveratrol as Cardioprotective Agent: Evidence from Bench and Bedside: Sukesh Burjonroppa and Ken Fujise
Immunomodulation by Resveratrol: Subhash C. Gautam, Xiaohua Gao, and Scott A. Dulchavsky
Biological Effects of Cis-Versus Trans-Resveratrol: Francisco Orallo
Resveratrol as an Antiinflammatory Agent: Young-Joon Surh and Joydeb Kumar Kundu
Neuroprotective Effects of Resveratrol: Ying-Shan Han, Stéphane Bastianetto, and Rémi Quirion
Pharmacokinetics and Metabolism of Resveratrol: Alberto A. E. Bertelli