Scaffolding In Tissue Engineering: 1st Edition (Hardback) book cover

Scaffolding In Tissue Engineering

1st Edition

Edited by Peter X. Ma, Jennifer Elisseeff

CRC Press

656 pages | 241 B/W Illus.

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pub: 2005-08-19
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The growing interest in scaffolding design and increasing research programs dedicated to regenerative medicine corroborate the need for Scaffolding in Tissue Engineering. While certain books and journal articles address various aspects in the field, this is the first current, comprehensive text focusing on scaffolding for tissue engineering.

Scaffolding in Tissue Engineering reviews the general principles of tissue engineering and concentrates on the principles, methods, and applications for a broad range of tissue engineering scaffolds. The first section presents an in-depth exploration of traditional and novel materials, including alginates, polysaccharides, and fibrillar fibrin gels. The following section covers fabrication technologies, discussing three-dimensional scaffold design, laboratory-scale manufacture of a cell carrier, phase separation, self-assembly, gas foaming, solid freeform fabrication, injectable systems, and immunoisolation techniques. Subsequent chapters examine structural and functional scaffold modification, composite scaffolds, bioactive hydrogels, gene delivery, growth factors, and degradation of biodegradable polymers. The final section explores various tissue engineering applications, comprising chapters on blood cell substitutes, and tissue engineering of nerves, the tendons, ligaments, cornea, cartilage and myocardium, meniscal tissue.

While providing a comprehensive summary of current knowledge and technologies, Scaffolding in Tissue Engineering gives readers insight into new trends and directions for scaffold development and for an ever-expanding range of tissue engineering applications.


"The editors certainly succeeded in their purpose to produce a robust and outstanding book…Scaffolding in Tissue Engineering brought together an extraordinary amount of information related to the use of scaffolds in TE. It is unquestionably destined to be a classic book that deserves a place on the shelves of every researcher in TE and libraries. Congratulations to the editors and to all contributors for this exceptional book."

-Eduardo Abreu, Biomedical Engineering Online, October 2006

Table of Contents


Biologically Active Scaffolds based on Collagen-GAG Copolymers; Ioannis V. Yannas

Alginate for Tissue Engineering; Peter X. Ma

Polysaccharides Scaffolds for Tissue Engineering; Tirtsa Ehrenfreund-Kleinman, Jacob Golenser, and Abraham J. Domb

Role of Gelatin in the Release Carrier of Growth Factor for Tissue Engineering; Yasuhiko Tabata

Fibrillar Fibrin Gels; Erin Grassl and Robert T. Tranquillo

Photopolymerization of Hydrogel Scaffolds; Stephanie J. Bryant and Kristi S. Anseth

Poly(ortho esters); J. Heller, J. Barr, D.T. Shah, S.Y. Ng, H.-R Shen, and B.B. Baxter


Salt-Leaching for Polymer Scaffolds: Laboratory-Scale Manufacture of Cell Carriers; Joerg K.V. Tessmar, Theresa A. Holland, and Antonios G. Mikos

Phase Separation for Polymer Scaffolds; Victor J. Chen and Peter X. Ma

Solid Freeform Fabrication of Tissue Engineering Scaffolds; Tien-Min G. Chu

Gas Foaming to Fabricate Polymer Scaffolds in Tissue Engineering; Yen-Chen Huang and David J. Mooney

Injectable Systems for Cartilage Tissue Engineering; Christopher G. Williams and Jennifer H. Elisseeff

Immunoisolation Techniques; Beth Anne Zielinskip

Self-Assembled Monolayers in Mammalian Cell Cultures; Xingyu Jiang, Jassamine Ng Lee, and George M. Whitesides

PuraMatrix: Self-assembling Peptide Nanofiber Scaffolds; Shuguang Zhang, Xiaojun Zhao, and Lisa Spirio


Polymer/Ceramic Composite Scaffolds; Guobao Wei, Peter X. Ma

Polymer/Calcium Phosphate Scaffolds; Cato T. Laurencin and Yusuf Khan

Hydroxyapatite/Collagen Scaffolds; Chang Du, Fu-Zhai Cui, and Klaas de Groot

Bioactive Hydrogels: Mimicking the ECM with Synthetic Materials; Jennifer West

Albumin Modification; Sang Cheon Lee, Yoon Yeo, and Kinam Park

Modified Alginates for Tissue Engineering; Yen-Chen Huang and David Mooney

Gene Delivery in Regenerative Medicine; Kam W. Leong

Degradation of Biodegradable Aliphatic Polymers; Suming Li


Biomaterials for Genitourinary Tissue Engineering; Priyabrata Mukherjee and Anthony Atala

Engineered Blood Vessel Substitutes; Jan P. Stegemann, Shaneen L. Rowe, and Robert M. Nerem

Tissue Engineering of Tendon and Ligament; Changming Guo and Myron Spector

Tissue Engineering of the Cornea; May Griffith, Fengfu Li, Chris Lohman, Heather D. Sheardown, Shigeto Shimmura, and David J. Carlsson

Materials Employed for Breast Augmentation and Reconstruction; Parul Natvar Patel and Charles W. Patrick Jr.

Scaffolding in Periodontal Engineering; Orasa Anusaksathien, Qi-ming Jin, Peter X. Ma, and William V. Giannobile

Tissue Engineering of Craniofacial Structure; Kacey G. Marra, Mark P. Mooney, and Jeffrey O. Hollinger

Hemoglobin-Based Red Blood Cell Substitutes; Thomas M. S. Chang

Nerve Regeneration; Erin Lavik and Robert Langer

Functional Tissue Engineering of Cartilage and Myocardium: Bioreactor Aspects; Milica Radisic, Bojana Obradovic, and G. Vunjak-Novakovic

Stem Cells in Tissue Engineering; Victor Prisk and Johnny Huard

Osteochondral Tissue Engineering - Regeneration of Articular Condyle from Mesenchymal Stem Cells; Adel Alhadlaq and Jeremy J. Mao

Tissue Engineered Meniscal Tissue; Mark A. Randolph, MAS and Thomas J. Gill

Tissue Engineering for Insulin Replacement in Diabetes; Amy S. Lewis and Clark K. Colton

3-D Tissue Fabrication: Application to Hepatic Tissue Engineering; Valerie A. Liu and Sangeeta N. Bhatia

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
SCIENCE / Biotechnology