The first volume of Stem Cells deals with the fundamental principles that govern embryonic and somatic stem cell biology. Historically, the identification and characterization of such pathways and general rules of stemness occurred during embryonic development and Volume I reflects this with topics spanning cell cycle regulation, epigenetics, and asymmetric cell division in a number of organ systems from planarian to human. Three specific sections discuss i) Basic Stem Cell Biology, ii) Tissue Formation During Development, and iii) Model Organisms with particular emphasis on those more relevant for biomedical research and, thus, leading to the topics addressed in Volume II.
"…covers the basics as well as the development of a variety of tissues with known stem cells/progenitor cells and stem cell models currently being used in the authors' laboratories. …it would be beneficial to those who wish to use a nonrodent model."
—Ellen Mary Andrews, PhD, Midwestern University
Basic Stem Cell Biology. Cell Cycle Regulation of Pluripotent Stem Cells. Asymmetric Cell Divisions and Nuclear Migration of Neural Progenitors: Two Mechanisms that Influence Neurogenesis. Epigenetic Regulation of Adult Stem Cells. Hematopoietic Stem Cell Aging and Oxidative Stress. Bioelectric Controls of Stem Cell Function. Tissue Formation During Development. Development From the Fertilized Egg to the Three Layers and its Relevance to Signaling and Lineage Commitment of Ebryonic Stem Cells. Hematopoiesis During Embryonic Development. Neural Progenitors and Evolution of Mammalian Neocortex. Dynamic Gene Networks in Neural Stem Cell Regulation. Stem Cells in the Development, Regeneration and Repair of the Retina. Progenitor Cells in Embryonic and Adult Lungs. Cells During Tooth Development. Liver and Pancreas: Mechanisms of Development. Model Organisms. Developmental Regulation and de novo Formation of Stem Cells in Plants. Planarian Totipotent Stem Cells. Zebrafish in Stem Cell Research. Deer Antler Stem Cells – New Aspects and Findings. Genetic Manipulation of Pluripotent Stem Cells.