Structured Biological Modelling: A New Approach to Biophysical Cell Biology, 1st Edition (Hardback) book cover

Structured Biological Modelling

A New Approach to Biophysical Cell Biology, 1st Edition

By Michael Kraus, Bernhard Wolf

CRC Press

240 pages

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Hardback: 9780849347726
pub: 1995-07-31
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Structured Biological Modelling presents a straightforward introduction for computer-aided analysis, mathematical modelling, and simulation of cell biological systems. This unique guide brings together the physiological, structural, molecular biological, and theoretical aspects of the signal transduction network that regulates growth and proliferation in normal and tumor cells. It provides comprehensive survey of functional and theoretical features of intracellular signal processing and introduces the concept of cellular self-organization. Exemplified by oscillatory calcium waves, strategies for the design of computer experiments are presented that can assist or even substitute for time-consuming biological experiments. The presented minimal model for proliferation-associated signal transduction clearly shows the alterations of the cellular signal network involved in neoplastic growth. This book will be useful to cell and molecular biologists, oncologists, physiologists, theoretical biologists, computer scientists, and all other researchers and students studying functional aspects of cellular signaling.

Table of Contents


Holistic Approaches for Data Acquisition in Cell Biology-The Basis for SBM

Holistic Versus Molecular Biological Methods: A Fundamental Complementarity Between Experimental Strategies

Selected Minimal-Invasive Techniques for Holistic Data Acquisition in Cell Biology

Analytical Light Microscopy

Analytical Electron Microscopy

Further Analytical Techniques with Relevance for SBM

Image Analysis

Cellular Biosensors: Powerful Electrical Devices for the Detection of Biomolecular Signals

Structured Biological Modelling (SBM)-Technique and Applications

The SBM Cycle

Preliminary Remarks about the Modelling of Biological Systems

Structured Analysis

Mathematical Specification of the DFD Model

Stochastic Simulation of the Mathematical Model

SBM Applied to Intracellular Ca2+ Oscillations

The Experimental Basis

Critical Discussion of Minimal Models for Intracellular Ca2+ Oscillations

Microscopic View of Ca2+ Oscillators Represented by Stochastic Models: The Stochastic Two-Pool Oscillator

A SBM Model for Oscillatory Intracellular Ca2+ Waves in Nonexcitable Cells

Minimal Model of the Cellular Signal Transduction Network

The Cell Cycle

Modules of the Intracellular Signal Network

Structured Analysis of Proliferation-Associated Cell Signaling

The Minimal Model of the Mitogenic Signal Transduction Network: Discussion and Outlook

Emergence of Self-Organization in Tumor Biology

Brief Phenomenology of Self-Organized Cellular Structures

Physical Preliminaries

Phase Transitions in Cell Cycle and Neoplastic Growth

Neoplastic Growth as a Process of Cellular Self-Organization?

The Hierarchy of Biological Systems: Microenvironmental Hydrogen Ion Concentration as Central Order Parameter for Invasive Tumor Growth

Summary and Outlook


Subject Categories

BISAC Subject Codes/Headings:
SCIENCE / Life Sciences / Cytology
SCIENCE / Life Sciences / Biology / Molecular Biology
SCIENCE / Life Sciences / General