1st Edition

Synbiotics in Metabolic Disorders Mechanisms, Therapeutic Potential, and Future Perspectives

Edited By Neeraj Mishra, Sumel Ashique, Arshad Farid, Ashish Garg Copyright 2025
    312 Pages 36 B/W Illustrations
    by CRC Press

    This book explores the potential role of prebiotics, probiotics, and synbiotics in managing various metabolic disorders, chronic diseases, and metabolic syndromes. The initial chapter provides an overview of metabolic disorders, including their classification, symptoms, and underlying causes. Additionally, the chapter discusses the intricate signaling pathways and mechanisms through which prebiotics, probiotics, and synbiotics interact with the human body in relation to type-2 diabetes, obesity, Phenylketonuria, and Hemochromatosis. Additionally, the book highlights the potential impact of probiotics and synbiotics on oxidative stress, inflammation, lipid metabolism, and blood pressure. Further, the book focuses on the gut-brain axis and how synbiotics may influence neurotransmitter metabolism. With an emphasis on the gut-microbiota axis, this book presents a compelling narrative that explores the rationality behind synbiotic use and offers a glimpse into future perspectives for managing metabolic disorders effectively. This book is intended for researchers in the fields of nutraceuticals, nanomedicine, endocrinology, nutrition, gastroenterology, and metabolic medicine who are working in the field of probiotics, prebiotics, and symbiotics for the treatment of metabolic disorders.


    Yash Jasoria1, Mohit Agrawal2, Hema Chaudhary3


    Chapter 2: Targeting signaling pathway and mechanism of prebiotics, probiotics and symbiotics to manage metabolic disorders

    Monika Kaushik1, Prathap Madeswaraguptha1, Murugesan Vanangamudi1, Vijayaraj Surendran2, Navaneetha Krishnan Subramaniyan2, Ashok Kumar3,*


    Chapter 3: Potential Role of Probiotics, Prebiotics and Synbiotics in Management of Metabolic Syndrome and Chronic Metabolic Disease

    Md. Khokon Miah Akanda, Sanzia Mehjabin



    Nisha Sharma1, Prakash Chandra Gupta1, Swarnakshi Upadhyay1, Kamla Pathak2*


    Chapter 5: Therapeutic Potential of Gut Microbiota in Metabolic Disorders

    Akash Kumar1, Jhilam Pramanik 2, Nandani Goyal3, Mukesh Kumar4, Aarzoo Jangra1, Bhagavathi Sundaram Sivamaruthi 5, 6, Bhupender Prajapati 7, Sudarshan Singh 5,8*, Popat Mohite 9, Abhijeet Puri9


    Chapter 6: Therapeutic Potential of Gut Microbiota in Metabolic Disorders


    Anas Islam, Aditya Singh, Asad Ahmad, Badruddeen1, Juber Akhtar1, Usama Ahmad1, Mohammad Irfan Khan1, Mohammad Ahmad, Yusuf Asad2*



    Chapter 7: The Impact of probiotic and synbiotic supplementation on oxidative stress and inflammation


    Himanshu Sharma1, Sanjesh Kumar2, Sumel Ashique3*, Pratibha Bhowmick3, Radheshyam Pal4, Arshad Farid5, Roomah Javed5, Farzad Taghizadeh-Hesary 6,7 , Subhajit Mandal8



    Chapter 8: Correlation and Successive Role of Synbiotics to Manage Blood Pressure


    Himanshu Sharma1*, Monika Kaushik2, Venishaa S3, Rashmi Pathak4, Arshad Farid5, Mithun Bhowmick6


    Chapter 9: Synbiotics: A novel paradigm for Phenylketonuria management by targeting gut-microbiota and get-brain axis

    Sana Fatima1, Muhammad Muzammal1, Shaista Naz1, Muzammil Ahmad Khan1, Alamgir Khan1, Arshad Farid1, Wasim shah2*


    Chapter 10: Synbiotic: Potential Role in Hemochromoatosis Management


    Monika Kaushik1*, Himanshu Sharma2, Prathap Madeswaraguptha1, Venishaa S3, Murugesan Vanangamudi1



    Chapter 11: Correlation between synbiotic supplements and lipid metabolism: a novel strategy to counter attack metabolic disorders


    Alamgir Khan1, Arshad Farid1, Fazal Haq2, Sohail Ahmad1, Amin Ullah3, Muhammad Muzammal1, Muhammad Ajmal Khan4*





    Priyanka Ray1, Mohammad Abdul Faseeh2, Debojyoti Adak2*, Himanshu Sharma3



    Chapter 13: Impact of Bacterial metabolites on the gut environment to manage metabolic disorders

    Sohail Ahmad1, Maria Faraz1, Muhammad Badar1, Alamgir Khan1, Roomah Javed1, Arshad Farid 1*



    Chapter 14: The Potential Role of Prebiotics, Probiotics, and Synbiotics in Cancer Prevention and Therapy


    Phool Chandra1*, Himanshu Sharma1, Neetu Sachan2



    Chapter 15: Key regulatory aspects of prebiotics, probiotics, and synbiotics in the management of metabolic disorders


    Innocent Ayesiga1, Shabnoor Iqbal2, Yusuf Kyejjusa3,4, Joash Okoboi5, Timothy Omara6, Thomas Adelina7, Delafrique Deogratias8, Arthur Amule Anyole8, Braize Ben Kagimu8, Denis Odongo8, Ivan Kahwa



    Chapter 16: Synbiotics: Present Status and Future Prospectives to Control Metabolic Disorders


    Sanzia Mehjabin1, Md. Khokon Miah Akanda2*, A. H. M. Nazmul Hasan2, G. M. Masud Parvez


    Dr. Neeraj Mishra has been working as a Professor at Amity Institute of Pharmacy, Gwalior, since July 2019. He has around twenty years of teaching and research experience. He has more than 100 publications of international and national repute on recent concepts of novel drug delivery systems, oral delivery of synbiotics, localized drug delivery, and targeted and controlled drug delivery of nanocarriers and microparticles for the treatment of breast, colon, and neurodegenerative disorders. He has also edited 10 books and authored 25 book chapters. He has been granted three international patents and two Indian patents. Dr. Mishra is the recipient of the “Distinguished Professor Award” 2019 from DST-NSTMIS, SPAICS, Indore, and M.P. in September 2019. Dr. Mishra has also received the “Outstanding Scientist Award '' 2020, 6th International Scientist Awards on Engineering, Science, and Medicine, 20–21 June 2020, Chennai, India. Dr. Mishra has received the “Distinguished Professor Award '' 2021 from the Indian Pharmaceutical Association, MP State Branch, Indore. Dr. Mishra has received the “Best Academician Award” in the Indian Pharmacy Graduate Association, M.P. State International Conference held on May 6, 2023, at DAVV Auditorium, Indore, India.


    Dr. Sumel Ashique has been working as an Assistant Professor at Department of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur 713212, West Bengal, India. He has 3.5 years of teaching experience and has published more than 50 researches and review articles in internationally and nationally accredited, reputed journals. He has been working in targeted drug delivery, nanotechnology, and gut microbiome. He has also been granted 5 patents from IP and Australia and has authored more than 20 book chapters. He has edited 5 books under CRC Press, springer, wiley and Taylor-Francis Publisher.


    Dr. Arshad Farid is a distinguished academic and researcher with a prolific career spanning over 15 years in teaching and research. He is currently serving as an Assistant Professor in the Gomal Center of Biochemistry and Biotechnology at Gomal University, Pakistan. He completed his Ph.D. in Biotechnology from the Centre of Biotechnology and Microbiology (COBAM), University of Peshawar, Pakistan. His remarkable achievements have garnered him international recognition, as evidenced by his selection for the British Council-Charles Wallace Fellowship program for the academic year 2022-2023. In 2007, he was also awarded a prestigious scholarship to the University of Glasgow, UK, funded by the Higher Education Commission (HEC) of Pakistan. He has authored or co-authored more than 70 research papers and has been granted nine patents.


    Dr. Ashish Garg obtained a B. Pharm. in 2011 and a M. Pharm. in 2013 from Guru Ramdas Khalsa Institute of Science and Technology, Pharmacy, Jabalpur, M.P., India. He has pursued his Ph.D. from SRK University, M.P. He has over 10 years of experience in both teaching and research. He has authored more than 100 research and review articles published in national and international journals of high repute. Additionally, he has edited ten books and been awarded three patents and one design patent. He is presently working as an Associate Professor in the Department of Pharmaceutics at Guru Ramdas Khalsa Institute of Science and Technology, Jabalpur, Madhya Pradesh, India.