1st Edition
Textbook of Ion Channels Volume II Properties, Function, and Pharmacology of the Superfamilies
The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging refer- ence source on ion channels for students, instructors and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excit- able tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs.
Volume II starts with ion channel taxonomy and features coverage of major ion channel families, and describes the physiological role, structural components, gating mechanisms and biophysics, permeation and selectivity, regulation, pharmacology, and roles in dis- ease mechanisms. Channels in this volume include voltage-activated sodium, calcium and potassium channels, inward-rectifier and two-pore domain potassium channels, calcium- activated potassium channels, cyclic nucleotide-gated channels, pacemaker ion channels, chloride channels, ligand-gated receptors activated by acetylcholine, glutamate, 5-HT3, GABA and glycine, acid-sensing channels, P2X receptors, TRP channels, store-operated channels, pressure-activated piezo channels, ryanodine receptors, and proton channels.
All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels; a guide to the technical aspects of ion channel research; offer a modern guide to the properties of major ion channel families; and include coverage of key examples of regulatory, physiological and disease roles for ion channels.
Chapter 1: Taxonomy and Evolution of Ion Channels
Timothy Jegla, Benjamin T. Simonson
Chapter 2: Voltage-Gated Sodium Channels
William A. Catterall
Chapter 3: Voltage-Gated Calcium Channels
Jacqueline Niu, Henry M. Colecraft
Chapter 4: Voltage-Gated Potassium Channels
Francis I. Valiyaveetil
Chapter 5: ERG Family of K Channels
Sara Codding, Matthew C. Trudeau
Chapter 6: KCNQ Channels
Anastasios V. Tzingounis and H. Peter Larsson
Chapter 7: BK Channels
Jianmin Cui
Chapter 8: Small-Conductance Calcium-Activated Potassium (SK) Channels
Miao Zhang, Heike Wulff
Chapter 9: Inward Rectifier Potassium Channels
Camden Driggers, Min-Woo Sung, Show-Ling Shyng
Chapter 10: Two-Pore Domain Potassium Channels
Leigh D. Plant, Steve A. N. Goldstein
Chapter 11: Cyclic Nucleotide-Gated Channels
Michael D. Varnum
Chapter 12: HCN Channels
Colin H. Peters, Catherine Proenza
Chapter 13: CLC Chloride Channels and Transporters
Anna K. Koster, Merritt Maduke
Chapter 14: Ca-Activated Cl- Channels
Criss Hartzell
Chapter 15: Acetylcholine Receptors
Cecilia Bouzat, Juan Facundo Chrestia
Chapter 16: Ionotropic Glutamate Receptors
Andrew Plested
Chapter 17: 5-HT3 Receptors
Susanne M. Mesoy, Sarah C. R. Lummis
Chapter 18: GABAA Receptors
Trevor G. Smart
Chapter 19: Glycine Receptors
Josip Ivica, Lucia Sivilotti
Chapter 20: Acid Sensing Ion Channels
Yangyu Wu, Cecilia M. Canessa
Chapter 21: ENaC Channels
Mike Althaus, Diego Alvarez de la Rosa, Martin Fronius
Chapter 22: TRPC Channels
Jin Bin Tian, Michael X. Zhu
Chapter 23: TRPM Channels
David D. McKemy
Chapter 24: TRPV Channels
Tamara Rosenbaum
Chapter 25: Store-Operated CRAC Channels
Murali Prakriya
Chapter 26: Piezo Channels
Jörg Grandl, Bailong Xiao
Chapter 27: Ryanodine Receptors
Jean-Pierre Benitah, Laetitia Pereira, Liheng Yin, Jean-Jacques Mercadier, Marine Gandon-Renard, Almudena Val-Blasco, Romain Perrier, A. M. Gomez
Chapter 28: Proton Channels
Emily R. Liman, I. Scott Ramsey
Chapter 29: P2X Receptors
Kate Dunning, Thomas Grutter
Biography
Jie Zheng, PhD, is a professor at the University of California Davis School of Medicine, where he has served as a faculty member in the Department of Physiology and Membrane Biology since 2004. Dr. Zheng earned a bachelor’s degree in physiology and biophysics (1988) and a master’s degree in biophysics (1991) at Peking University. He earned a PhD in physiology (1998) at Yale University, where he studied with Dr. Fredrick J. Sigworth on patch-clamp recording, single-channel analysis, and voltage-dependent activation mechanisms. He received his postdoctoral training at the Howard Hughes Medical Institute (HHMI) and the University of Washington during 1999–2003, working with Dr. William N. Zagotta on the cyclic nucleotide-gated channels activation mechanism and novel fluorescence techniques for ion channel research. Currently, Dr. Zheng’s research focuses on temperature-sensitive TRP channels.
Matthew C. Trudeau, PhD, is a professor in the Department of Physiology at the University of Maryland School of Medicine in Baltimore, Maryland. He earned a bachelor’s degree in biochemistry and molecular biology in 1992 and a PhD in physiology in 1998 while working with Gail Robertson, PhD, at the University of Wisconsin-Madison. His thesis work was on the properties of voltage-gated potassium channels in the human ether-aì-go-go related gene (hERG) family and the role of these channels in heart disease. Dr. Trudeau was a postdoctoral fellow with William Zagotta, PhD, at the University of Washington and the Howard Hughes Medical Institute (HHMI) in Seattle from 1998 to 2004, where he focused on the molecular physiology of cyclic nucleotide-gated ion channels, the mechanism of their modulation by calcium-calmodulin, and their role in an inherited form of vision loss. Currently, Dr. Trudeau’s work focuses on hERG potassium channels, their biophysical mechanisms, and their role in cardiac physiology and cardiac arrhythmias.
