Textbook of Ion Channels Volume II : Properties, Function, and Pharmacology of the Superfamilies book cover
1st Edition

Textbook of Ion Channels Volume II
Properties, Function, and Pharmacology of the Superfamilies

  • Available for pre-order on April 27, 2023. Item will ship after May 18, 2023
ISBN 9780367538163
May 18, 2023 Forthcoming by CRC Press
496 Pages 124 Color & 7 B/W Illustrations

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Book Description

The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs.

Volume II starts with ion channel taxonomy and features coverage of major ion channel families and describes the physiological role, structural components, gating mechanisms and biophysics, permeation and selectivity, regulation, pharmacology and roles in disease mechanisms. Channels in this volume include voltage-activated sodium, calcium and potassium channels, inward-rectifier and two-pore domain potassium channels, calcium-activated potassium channels, cyclic-nucleotide gated channels, pacemaker ion channels, chloride channels, the ligand-gated receptors activated by acetylcholine, glutamate, 5-HT3, GABA and glycine, acid-sensing channels, P2X receptors, TRP channels, store-operated channels, pressure-activated piezo channels, ryanodine receptors and proton channels.

All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

Table of Contents

Chapter 1: Taxonomy and Evolution of Ion Channels 
Timothy Jegla, Benjamin T. Simonson

Chapter 2: Voltage-Gated Sodium Channels
William A. Catterall
Chapter 3: Voltage-Gated Calcium Channels
Jacqueline Niu, Henry M. Colecraft
Chapter 4: Voltage-Gated Potassium Channels
Francis I. Valiyaveetil 

Chapter 5: ERG Family of K Channels 
Sara Codding, Matthew C. Trudeau

Chapter 6: KCNQ Channels 
H. Peter Larsson

Chapter 7: BK Channels 
Jianmin Cui

Chapter 8: Small-Conductance Calcium-Activated Potassium (SK) Channels
Miao Zhang, Heike Wulff

Chapter 9: Inward Rectifier Potassium Channels 
Camden Driggers, Min-Woo Sung, Show-Ling Shyng

Chapter 10: Two-Pore Domain Potassium Channels 
Leigh D. Plant, Steve A. N. Goldstein

Chapter 11: Cyclic Nucleotide-Gated Channels 
Michael D. Varnum

Chapter 12: HCN Channels  
Colin H. Peters, Catherine Proenza

Chapter 13: CLC Chloride Channels and Transporters  
Anna K. Koster, Merritt Maduke

Chapter 14: Ca-Activated Cl- Channels 
Criss Hartzell

Chapter 15: Acetylcholine Receptors 
Cecilia Bouzat, Juan Facundo Chrestia

Chapter 16: Ionotropic Glutamate Receptors 
Andrew Plested

Chapter 17: 5-HT3 Receptors 
Susanne M. Mesoy, Sarah C. R. Lummis

Chapter 18: GABAA Receptors 
Trevor G. Smart

Chapter 19: Glycine Receptors  
Josip Ivica, Lucia Sivilotti

Chapter 20: Acid Sensing Ion Channels 
Yangyu Wu, Cecilia M. Canessa

Chapter 21: ENaC Channels 
Mike Althaus, Diego Alvarez de la Rosa, Martin Fronius

Chapter 22: TRPC Channels 
Jin Bin Tian, Michael X. Zhu

Chapter 23: TRPM Channels 
David D. McKemy

Chapter 24: TRPV Channels 
Tamara Rosenbaum

Chapter 25: Store-Operated CRAC Channels 
Murali Prakriya

Chapter 26: Piezo Channels 
Jörg Grandl, Bailong Xiao

Chapter 27: Ryanodine Receptors  
Jean-Pierre Benitah, Laetitia Pereira, Liheng Yin, Jean-Jacques Mercadier, Marine Gandon-Renard, Almudena Val-Blasco, Romain Perrier, A. M. Gomez

Chapter 28: Proton Channels  
Emily R. Liman, I. Scott Ramsey

Chapter 29: P2X Receptors  
Kate Dunning, Thomas Grutter

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Jie Zheng, PhD, is a professor at the University of California Davis School of Medicine, where he has served as a faculty member in the Department of Physiology and Membrane Biology since 2004. Dr. Zheng earned a bachelor’s degree in physiology and biophysics (1988) and a master’s degree in biophysics (1991) at Peking University. He earned a PhD in physiology (1998) at Yale University, where he studied with Dr. Fredrick J. Sigworth on patch-clamp recording, single-channel analysis, and voltage-dependent activation mechanisms. He received his postdoctoral training at the Howard Hughes Medical Institute (HHMI) and the University of Washington during 1999–2003, working with Dr. William N. Zagotta on the cyclic nucleotide-gated channels activation mechanism and novel fluorescence techniques for ion channel research. Currently, Dr. Zheng’s research focuses on temperature-sensitive TRP channels.

Matthew C. Trudeau, PhD, is a professor in the Department of Physiology at the University of Maryland School of Medicine in Baltimore, Maryland. He earned a bachelor’s degree in biochemistry and molecular biology in 1992 and a PhD in physiology in 1998 while working with Gail Robertson, PhD, at the University of Wisconsin-Madison. His thesis work was on the properties of voltage-gated potassium channels in the human ether-aì-go-go related gene (hERG) family and the role of these channels in heart disease. Dr. Trudeau was a postdoctoral fellow with William Zagotta, PhD, at the University of Washington and the Howard Hughes Medical Institute (HHMI) in Seattle from 1998 to 2004, where he focused on the molecular physiology of cyclic nucleotide-gated ion channels, the mechanism of their modulation by calcium-calmodulin, and their role in an inherited form of vision loss. Currently, Dr. Trudeau’s work focuses on hERG potassium channels, their biophysical mechanisms, and their role in cardiac physiology and cardiac arrhythmias.