1st Edition

Textbook of Ion Channels Volume II Properties, Function, and Pharmacology of the Superfamilies

Edited By Jie Zheng, Matthew C. Trudeau Copyright 2023
    488 Pages 124 Color & 7 B/W Illustrations
    by CRC Press

    488 Pages 124 Color & 7 B/W Illustrations
    by CRC Press

    The Textbook of Ion Channels is a set of three volumes that provides a wide-ranging refer- ence source on ion channels for students, instructors and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells; mediate the detection and response to sensory stimuli like light, sound, odor, and taste; and regulate the response to physical stimuli like temperature and pressure. In non-excit- able tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical appli- cations. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs.

    Volume II starts with ion channel taxonomy and features coverage of major ion channel families, and describes the physiological role, structural components, gating mechanisms and biophysics, permeation and selectivity, regulation, pharmacology, and roles in dis- ease mechanisms. Channels in this volume include voltage-activated sodium, calcium and potassium channels, inward-rectifier and two-pore domain potassium channels, calcium- activated potassium channels, cyclic nucleotide-gated channels, pacemaker ion channels, chloride channels, ligand-gated receptors activated by acetylcholine, glutamate, 5-HT3, GABA and glycine, acid-sensing channels, P2X receptors, TRP channels, store-operated channels, pressure-activated piezo channels, ryanodine receptors, and proton channels.

    All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels; a guide to the technical aspects of ion channel research; offer a modern guide to the properties of major ion channel families; and include coverage of key examples of regulatory, physiological and disease roles for ion channels.


    Chapter 1: Taxonomy and Evolution of Ion Channels 
    Timothy Jegla, Benjamin T. Simonson

    Chapter 2: Voltage-Gated Sodium Channels
    William A. Catterall
    Chapter 3: Voltage-Gated Calcium Channels
    Jacqueline Niu, Henry M. Colecraft
    Chapter 4: Voltage-Gated Potassium Channels
    Francis I. Valiyaveetil 

    Chapter 5: ERG Family of K Channels 
    Sara Codding, Matthew C. Trudeau

    Chapter 6: KCNQ Channels 

    Anastasios V. Tzingounis and H. Peter Larsson

    Chapter 7: BK Channels 
    Jianmin Cui

    Chapter 8: Small-Conductance Calcium-Activated Potassium (SK) Channels
    Miao Zhang, Heike Wulff

    Chapter 9: Inward Rectifier Potassium Channels 
    Camden Driggers, Min-Woo Sung, Show-Ling Shyng

    Chapter 10: Two-Pore Domain Potassium Channels 
    Leigh D. Plant, Steve A. N. Goldstein

    Chapter 11: Cyclic Nucleotide-Gated Channels 
    Michael D. Varnum

    Chapter 12: HCN Channels  
    Colin H. Peters, Catherine Proenza

    Chapter 13: CLC Chloride Channels and Transporters  
    Anna K. Koster, Merritt Maduke

    Chapter 14: Ca-Activated Cl- Channels 
    Criss Hartzell

    Chapter 15: Acetylcholine Receptors 
    Cecilia Bouzat, Juan Facundo Chrestia

    Chapter 16: Ionotropic Glutamate Receptors 
    Andrew Plested

    Chapter 17: 5-HT3 Receptors 
    Susanne M. Mesoy, Sarah C. R. Lummis

    Chapter 18: GABAA Receptors 
    Trevor G. Smart

    Chapter 19: Glycine Receptors  
    Josip Ivica, Lucia Sivilotti

    Chapter 20: Acid Sensing Ion Channels 
    Yangyu Wu, Cecilia M. Canessa

    Chapter 21: ENaC Channels 
    Mike Althaus, Diego Alvarez de la Rosa, Martin Fronius

    Chapter 22: TRPC Channels 
    Jin Bin Tian, Michael X. Zhu

    Chapter 23: TRPM Channels 
    David D. McKemy

    Chapter 24: TRPV Channels 
    Tamara Rosenbaum

    Chapter 25: Store-Operated CRAC Channels 
    Murali Prakriya

    Chapter 26: Piezo Channels 
    Jörg Grandl, Bailong Xiao

    Chapter 27: Ryanodine Receptors  
    Jean-Pierre Benitah, Laetitia Pereira, Liheng Yin, Jean-Jacques Mercadier, Marine Gandon-Renard, Almudena Val-Blasco, Romain Perrier, A. M. Gomez

    Chapter 28: Proton Channels  
    Emily R. Liman, I. Scott Ramsey

    Chapter 29: P2X Receptors  
    Kate Dunning, Thomas Grutter


    Jie Zheng, PhD, is a professor at the University of California Davis School of Medicine, where he has served as a faculty member in the Department of Physiology and Membrane Biology since 2004. Dr. Zheng earned a bachelor’s degree in physiology and biophysics (1988) and a master’s degree in biophysics (1991) at Peking University. He earned a PhD in physiology (1998) at Yale University, where he studied with Dr. Fredrick J. Sigworth on patch-clamp recording, single-channel analysis, and voltage-dependent activation mechanisms. He received his postdoctoral training at the Howard Hughes Medical Institute (HHMI) and the University of Washington during 1999–2003, working with Dr. William N. Zagotta on the cyclic nucleotide-gated channels activation mechanism and novel fluorescence techniques for ion channel research. Currently, Dr. Zheng’s research focuses on temperature-sensitive TRP channels.

    Matthew C. Trudeau, PhD, is a professor in the Department of Physiology at the University of Maryland School of Medicine in Baltimore, Maryland. He earned a bachelor’s degree in biochemistry and molecular biology in 1992 and a PhD in physiology in 1998 while working with Gail Robertson, PhD, at the University of Wisconsin-Madison. His thesis work was on the properties of voltage-gated potassium channels in the human ether-aì-go-go related gene (hERG) family and the role of these channels in heart disease. Dr. Trudeau was a postdoctoral fellow with William Zagotta, PhD, at the University of Washington and the Howard Hughes Medical Institute (HHMI) in Seattle from 1998 to 2004, where he focused on the molecular physiology of cyclic nucleotide-gated ion channels, the mechanism of their modulation by calcium-calmodulin, and their role in an inherited form of vision loss. Currently, Dr. Trudeau’s work focuses on hERG potassium channels, their biophysical mechanisms, and their role in cardiac physiology and cardiac arrhythmias.