The Blood-Brain Barrier and Its Microenvironment : Basic Physiology to Neurological Disease book cover
1st Edition

The Blood-Brain Barrier and Its Microenvironment
Basic Physiology to Neurological Disease

ISBN 9780849398926
Published August 24, 2005 by CRC Press
544 Pages 46 B/W Illustrations

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Book Description

This reference analyzes the cellular and molecular biology and mechanisms of the blood-brain barrier (BBB) and presents the most recent studies on the role of the BBB in the development and initiation of a wide range of physiological and pathological conditions affecting the central nervous system.

Table of Contents

Development of the Blood-Brain Barrier. Blood-Brain Barrier Genomics and Proteomics. Tight Junctions of the Blood-Brain Barrier. Trophic Factors and Cerebrovascular Regulation. Neuronal Influence at the BBB and Local Control of Microcirculation. The Transport Systems of the Blood-Brain Barrier. Drug Delivery Through the BBB: Non Viral Vectors. Immune Functions of Brain Endothelial Cells. T Cell Migration Across the Blood-Brain Barrier in CNS Inflammatory Diseases. Endothelial ICAM-1 Mediated Signalling and Its Role During Lymphocyte Migration into the CNS Parenchyma. Monocyte Migration across the BBB. Cerebral Perivascular Macrophages and the Blood-Brain Barrier. Chemokines at the Blood-Brain Barrier. Matrix Metalloproteinase and Proteolytic Opening of the Blood-Brain Carrier in Neuroinflammation. Endothelial cells, Extracellular Matrix and Astocytes: Interplay for Managing the Blood-Brain Barrier. Molecular Modulation of the Blood-Brain Barrier During Stroke. Apolipoprotein E, the Blood-Brain Barrier and Alzheimer's Disease. Techniques for Measuring the Blood-Brain Barrier Integrity. Influence of Brain Trauma on Blood-Brain Barrier Properties. Non-HIV Viral Interaction with the BBB

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