The Brain Cholinergic System  book cover
1st Edition

The Brain Cholinergic System

ISBN 9781841845753
Published April 19, 2006 by CRC Press
318 Pages 74 B/W Illustrations

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Book Description

The cholinergic system has been recognized as playing an important role not only in several forms of dementia besides Alzheimer's Disease, but also in other CNS degenerative and psychiatric disorders. Following on from the success of two previous publications in the cholinergic field - Cholinesterases and Their Inhibitors and Butyrylcholinesterase: Its Function and Inhibitors - Doctor Ezio Giacobini and Professor Giancarlo Pepeu have prepared this comprehensive and timely volume, which will be useful to both clinical and pre-clinical specialists including neurologists, psychiatrists, neuropsychologists, neuropharmacologists and neurophysiologists, molecular neurobiologists and neurobiologists in general.

Table of Contents


1. Milestones in the discovery and understanding of the brain cholinergic system

Alex Karczmar (Chicago, USA)

SECTION I. Neurobiology of the cholinergic neuron

2. Genetic regulation of the cholinergic system

Paul M. Salvaterra (Duarte, California, USA)

3. Trophic factors of the cholinergic neurons

Claudio A Cuello (Montreal, Canada)

SECTION II. Neuroanatomy of the cholinergic system

4. Aging and Alzheimer Disease

Marek-Marsel Mesulam (Chicago, USA)

SECTION III. Neurochemistry of the cholinergic system

5. From MCI to Dementia

Elaine Perry (Newcastle, UK)

SECTION III. Acetilcholine Synthesis, Inactivation and Release

6. Choline acetyltransferase

Rebecca Jane Rylett (London, Canada)

7. Precursors: choline and glucose

K Loeffelholz

8. Pre- and postsynaptic modulation of acetylcholine release

D.D. Rasmusson (Halifax, Canada)

SECTION IV. The cholinesterases

9-10. Molecular pharmacology and toxicological aspects of cholinesterases

Palmer W. Taylor (San Diego, USA)

SECTION V. What have we learned from transgenic mice?

11. Overexpression of acetylcholinesterases

Hermona Soreq (Jerusalem, Israel)


12. Acetylcholinesterase and Butyrylcholinesterase knockouts

Oksana Lockridge (Omaha, USA)

SECTION VI. Brain Acetylcholine Receptors

13. Molecular biology and behavioural role of nicotinic receptors

JP Changeux (Paris, France)

14. The pharmacology of brain nicotinic receptors

Francesco Clementi (Milan, Italy)

15. Brain muscarinic receptors: lessons from knock out mice

Jurgen Wess (Bethesda, USA)

16. Muscarinic agonists and antagonists

Abraham Fisher (Ness-Ziona, Israel)

17. PET studies of nicotinic and muscarinic receptors

Agneta Nordberg (Stockholm, Sweden)

SECTION VII. Roles of the cholinergic system

18. Cholinergic modulation of nervous transmission in the CNS

Mircea Steriade (Quebec, Canada)

19. The contribution of the cholinergic system to neuronal plasticity

Martin Sater (Ann Arbor, MI, USA)

20. The role of the cholinergic system in cognitive processes

Giancarlo Pepeu (Florence, Italy)


21. Therapeutic applications of cholinesterase inhibitors

Ezio Giacobini (Geneva, Switzerland)


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Ezio Giacobini MD, is Adjunct Professor, Institutions Universitaires de Gériatrie de Genève Thonex-Genève, Switzerland. The editor started to work in the field of cholinesterases in 1954. In 1959 he published his PhD Thesis at the Karolinska Institute, Stockholm with the title: Distribution and Localization of Cholinesterases in Nerve Cells Acta Physiol. Scand vol. 45 suppl 156 1959). Since then the author has continued to work on this topic and as of year 1998 has authored over 300 papers on this subject. He has edited Current Research (Taylor & Francis 1988), Advances in Experimental Medicine and Biology: Plasticity and Regeneration of the Nervous System (Plenum 1991), Alzheimer’s Disease: Current Research in Early Diagnosis (Taylor & Francis 1990), Cholinergic Basis for Alzheimer Therapy (Birkhauser 1991), Alzheimer’s Disease: Therapeutic Strategies (Birkhauser 1994), Alzheimer Disease: from Molecular Biology to Therapy (Birkhauser 1996), Cholinesterases and Cholinesetrase Inhibitors: Basic, Preclinical and Clinical Concepts (Dunitz, 2000), and Butyrylcholinesterase (Taylor & Francis, 2003).

Giancarlo Pepeu, MD, PhD, is Professor and Head of the Department of Preclinical and Clinical Pharmacology at the University of Florence, Florence, Italy.