1st Edition

The Brain Cholinergic System

Edited By Ezio Giacobini, Giancarlo Pepeu Copyright 2006
    288 Pages 74 B/W Illustrations
    by CRC Press

    The cholinergic system has been recognized as playing an important role not only in several forms of dementia besides Alzheimer's Disease, but also in other CNS degenerative and psychiatric disorders. Following on from the success of two previous publications in the cholinergic field - Cholinesterases and Their Inhibitors and Butyrylcholinesterase: Its Function and Inhibitors - Doctor Ezio Giacobini and Professor Giancarlo Pepeu have prepared this comprehensive and timely volume, which will be useful to both clinical and pre-clinical specialists including neurologists, psychiatrists, neuropsychologists, neuropharmacologists and neurophysiologists, molecular neurobiologists and neurobiologists in general.


    1. Milestones in the discovery and understanding of the brain cholinergic system

    Alex Karczmar (Chicago, USA)

    SECTION I. Neurobiology of the cholinergic neuron

    2. Genetic regulation of the cholinergic system

    Paul M. Salvaterra (Duarte, California, USA)

    3. Trophic factors of the cholinergic neurons

    Claudio A Cuello (Montreal, Canada)

    SECTION II. Neuroanatomy of the cholinergic system

    4. Aging and Alzheimer Disease

    Marek-Marsel Mesulam (Chicago, USA)

    SECTION III. Neurochemistry of the cholinergic system

    5. From MCI to Dementia

    Elaine Perry (Newcastle, UK)

    SECTION III. Acetilcholine Synthesis, Inactivation and Release

    6. Choline acetyltransferase

    Rebecca Jane Rylett (London, Canada)

    7. Precursors: choline and glucose

    K Loeffelholz

    8. Pre- and postsynaptic modulation of acetylcholine release

    D.D. Rasmusson (Halifax, Canada)

    SECTION IV. The cholinesterases

    9-10. Molecular pharmacology and toxicological aspects of cholinesterases

    Palmer W. Taylor (San Diego, USA)

    SECTION V. What have we learned from transgenic mice?

    11. Overexpression of acetylcholinesterases

    Hermona Soreq (Jerusalem, Israel)


    12. Acetylcholinesterase and Butyrylcholinesterase knockouts

    Oksana Lockridge (Omaha, USA)

    SECTION VI. Brain Acetylcholine Receptors

    13. Molecular biology and behavioural role of nicotinic receptors

    JP Changeux (Paris, France)

    14. The pharmacology of brain nicotinic receptors

    Francesco Clementi (Milan, Italy)

    15. Brain muscarinic receptors: lessons from knock out mice

    Jurgen Wess (Bethesda, USA)

    16. Muscarinic agonists and antagonists

    Abraham Fisher (Ness-Ziona, Israel)

    17. PET studies of nicotinic and muscarinic receptors

    Agneta Nordberg (Stockholm, Sweden)

    SECTION VII. Roles of the cholinergic system

    18. Cholinergic modulation of nervous transmission in the CNS

    Mircea Steriade (Quebec, Canada)

    19. The contribution of the cholinergic system to neuronal plasticity

    Martin Sater (Ann Arbor, MI, USA)

    20. The role of the cholinergic system in cognitive processes

    Giancarlo Pepeu (Florence, Italy)

    SECTION VIII. Therapy

    21. Therapeutic applications of cholinesterase inhibitors

    Ezio Giacobini (Geneva, Switzerland)



    Ezio Giacobini