1st Edition

The Chromosomal Imbalance Theory of Cancer The Autocatalyzed Progression of Aneuploidy is Carcinogenesis

By David Rasnick Copyright 2012
    360 Pages 14 Color & 3 B/W Illustrations
    by CRC Press

    The book deals with the chromosomal imbalance (aneuploidy) theory of cancer. The book explains how gene mutations are not powerful enough to cause cancer, describes how cancer is initiated and why progression takes years to decades, and accounts for the global or macroscopic characteristics that readily identify cancer. In addition, it clarifies why cancer cells often become drug resistant even to drugs they were never exposed, provides objective, quantitative measures for detecting cancer and monitoring its progression, and suggests non-toxic strategies of cancer therapy and prevention. In short, it posits that the autocatalyzed progression of aneuploidy is carcinogenesis.

    Introducing Cancer

    Boveri’s Theory of Cancer was Ahead of its Time
    Aneuploidy theory "Got Lost"

    Genesis of "The Enemy Within"?
    Clonal cancer
    Tumorigenic retroviruses
    Dominate oncogenes
    Tumor suppressor genes
    Driver genes

    Gene Mutation Theory of Cancer
    "Carcinogens are mutagens
    Retroviral oncogenes
    Are "cellular oncogenes" like retroviral oncogenes?
    Updated gene mutation theory is popular but unconfirmed

    The Chromosomal Imbalance Theory of Cancer
    Heuristic explanation of how chromosomal imbalance (and not gene mutation) generates cancer phenotypes
    Aneuploidy causes chromosomal instability—the hallmark of cancer
    Cancer is a progressive somatic aneuploidy Syndrome
    Quantitative analysis of how aneuploidy generates new cellular phenotypes

    Theory of Chromosomal Imbalance Solves Mysteries and Paradoxes
    Carcinogenesis is dependent on aneuploidy and not mutation
    Aneuploidy causes the Warburg effect by increasing ATP demand
    Balanced mitotic forces and species-specific sequential chromatid separation may govern the rate of transformation
    Cancer vaccine is very unlikely
    "Cancers are a genuine type of species"

    New Perspectives for Cancer Prevention, Diagnosis and Therapy
    International regulation of aneuploidy-inducing agents
    Cancer detection
    Cancer therapy



    Rasnick, David