1st Edition
Therapeutic Potential of Natural Products in Neurodegenerative Disorders
About the Editors
PART I Neurodegenerative Disorder and Correlation with Natural Ingredients
Chapter 1 General Introduction of Neurodegenerative Disorders
Nayudu Teja, Sounderrajan Vijayakhiruba, Vadabam Valasa Reddy,
Neelufar Shaik, Aparna Baliwada, and Amol S. Rakte
Chapter 2 Role of Natural Herbs in Alzheimer’s Disease and Their Future Prospects
Gifty M. Jojo, Jobin Johnson, Gowthamarajan Kuppusamy,
and Karri V. V. S. Narayana Reddy
Chapter 3 Polyphenols and Other Agents with Their Uses for Amyotrophic Lateral Sclerosis
Subhasri Bogadi, Gowthamarajan Kuppusamy,
and Karri V. V. S. Narayana Reddy
Chapter 4 Natural Ingredients for Friedreich’s Ataxia
Madhu Tanya Singh, Sai Varshini Magham, Raja Shekhar Nunavath,
Sai Kiran S. S. Pindiprolu, and Praveen Thaggikuppe Krishnamurthy
Chapter 5 The Effect of Natural Ingredients and Their Combination for Huntington’s Disease
Nagasen Dasari, Sankhanil Panda, Sunanda Kaligithi,
and Sai Kiran S.S. Pindiprolu
Chapter 6 Lewy Body Disease and Its Therapeutic Regimen Using Conventional Methods
Sagarkanta Mohanty, Srikanth Jupudi, Neeru Dugar, Swati Swagatika Swain,
and Nayudu Teja, and Karri V. V. S. Narayana Reddy
Chapter 7 Parkinson’s Disease and Synergistic Effect of Natural and Synthetic Agents
K.M. Muhasina, Mehrukh Zehravi, N.P. Deepika, Krishnaveni Nagappan,
Md Ekhtiar Uddin, and Dhanabal S. Palaniswamy
Chapter 8 Natural Extracts for Spinal Muscular Atrophy
Swati Swagatika Swain, Karri V. V. S. Narayana Reddy,
Gowthamarajan Kuppusamy, Subhasri Bogadi, Sagarkanta Mohanty,
Ashish Sriram Mishra, and Vetriselvan Subramaniyan
Chapter 9 Synthetic Way of Management in General
Magham Sai Varshini, Madhu Tanya Singh, Sai Kiran S.S. Pindiprolu,
Praveen Thaggikuppe Krishnamurthy, and R. Aishwarya Reddy
Chapter 10 Credentials of Natural Therapy over Synthetic Treatment
Vetriselvan Subramaniyan, Muralikrishnan Dhanasekaran, Mukesh Kumar,
Sivaraman Dhanasekaran, Srikanth Jeyabalan, Gowthamarajan Kuppusamy,
and Karri V. V. S. Narayana Reddy
Chapter 11 Nano-Delivery System for the Management of Neurodegenerative Disorder
Sai Kiran S.S. Pindiprolu, Ramakrishna Gummadi, Nagasen Dasari,
and Chirravuri Satyanarayana Phani Kumar
PART II Neurodegenerative Disease and Its Therapeutic Approaches
Chapter 12 Synergistic Approach and the Treatment of Neurodegenerative Disorder
Nusrat K. Shaikh
Chapter 13 Electron Spinning and Electron Spraying Techniques and Their Correlation with Neurodegenerative Disorders
Subhasri Bogadi, Gowthamarajan Kuppusamy, Karri V. V. S. Narayana Reddy,
and Swati Swagatika Swain
Chapter 14 Neurodegenerative Disease and Its Therapeutic Approaches: Formulation Approach for Overcoming the Barriers during the Treatment of Neurodegenerative Disorder
Koushik Yetukuri, M.S. Umashankar, Sandeep Kanna, and Rama Rao Nadendla
Chapter 15 Food and Nutrition as a Medicine Class for the Prevention and Treatment of Neurodegenerative Disorder
Vetriselvan Subramaniyan, Muralikrishnan Dhanasekaran,
Mukesh Kumar, Mahendran Sekar, Neeraj Kumar Fuloria, Shivkanya Fuloria,
Gowthamarajan Kuppusamy, and Karri V. V. S. Narayana Reddy
Chapter 16 Flavonoids: Role in Neurodegenerative Studies
Swathi Nalla, Nagaraju Bandaru, Teja Naidu, and Vadabam Valasa Reddy
Chapter 17 Side Effects during Treatment of Neurodegenerative Disorder
Swathi Nalla, Nagaraju Bandaru, Nayudu Teja, and Vadabam Valasa Reddy
Chapter 18 Differentiation between Synthetic and Natural Treatment Modalities
Deepak Vasudevan Sajini and Amritha Chakkitukandiyil
Chapter 19 Challenges during the Use of Natural Remedies for Neurodegenerative Disorders
K.M. Muhasina, Puja Ghosh, Mehrukh Zehravi, N.P. Deepika,
Krishna Veni Nagappan, Md Ekhtiar Uddin, and Dhanabal S. Palaniswamy
Chapter 20 Conclusion and Future Aspects during Treatment of Neurodegenerative Disorders
Mirunalini Gobinath, L. Priyanka Dwarampudi, R. Shanmugam,
Parikshit Roychowdhury, and Subhajit Dutta
Index
Biography
Ghulam Md Ashraf is an accomplished biochemist and molecular neuroscientist with 15 years of experience in research, teaching, and innovation across the biological, health, and medical sciences. He holds a dual degree—Ph.D. in Biochemistry (Aligarh Muslim University, India) and PGDBA in Operations Management (Symbiosis Center for Distance Learning, India)—and completed the prestigious Instructional Skills Workshop (ISW) in collaboration with the University of British Columbia, Canada, enhancing his pedagogical expertise. His research focuses on molecular mechanisms and therapeutic strategies for neurodegenerative disorders, including multiple sclerosis and Alzheimer’s disease. His lab investigates serotonin receptor signaling, develops selective modulators to counteract pathological protein aggregation, and advances next-generation Multiple Sclerosis therapies, including engineered interferons and nanomedicine-based neuroprotective delivery. Dr. Ashraf is recognized among the Top 2% of Scientists Worldwide since 2021 (Stanford–PLOS–Elsevier), the leading Biochemistry Scientist in the UAE (AD Scientific Index), and a World Expert in Neurodegenerative Diseases (Expertscape). He is listed in Marquis Who’s Who in the World (since 2020), has received the Publons/Web of Science Top Reviewer Awards in Cross-Field and Biology & Biochemistry (2019), holds 4 international patents, and has authored nearly 450 publications with ~20,000 citations (H-index ~70). Dr. Ashraf has held leadership roles in research administration and laboratory management and has extensive editorial experience with journals including Journal of Advanced Research, Scientific Reports, and Plos One. He is a Fellow of the Royal Society of Medicine (FRSM), a Member of the Royal Society of Biology (MRSB), and an active member of international scientific societies such as the Canadian Academy of Neuroscience and the American Society for Biochemistry and Molecular Biology. Dr. Ashraf’s work exemplifies the integration of advanced research, innovation, and global collaboration to advance biomedical science and improve human health.
Md. Habibur Rahman is Registered Pharmacist in Bangladesh and a member of the Novel Global Community Education Foundation (Australia). He earned his Ph.D. in Medical Science from Yonsei University, South Korea, and has contributed his expertise to several leading pharmaceutical organizations. His research is primarily focused on neuroscience, particularly the molecular mechanisms underlying clinical dementia, with emphasis on biomarker discovery and targeted diagnostic strategies. In addition to his neuroscience work, Dr. Rahman is an expert in molecular biology, with extensive experience in gene expression analysis, oxidative stress pathways, and neuroinflammation. He has been recognized among the top 2% of scientists worldwide (Stanford University, citation-based global ranking) for his impactful contributions. Dr. Rahman is also an active scientific communicator and public speaker, frequently presenting at international conferences and academic forums. He serves as a peer reviewer for several high-impact journals and is involved in multiple ongoing research collaborations in neuroscience and molecular medicine.
Karri V. V. S. Narayana Reddy is Associate Professor in the Department of Pharmaceutics at JSS College of Pharmacy, Ooty, India. A proud alumnus of the same institution, he completed his B.Pharm, M.Pharm, and Ph.D. in Pharmaceutics from JSS College of Pharmacy, Ooty. Recognized among the Top 2% of Scientists in the World by Stanford University for three consecutive years (2022, 2023, and 2024), Dr. Reddy has made significant contributions to pharmaceutical sciences. His expertise spans nanodrug delivery, diabetic wound healing, and biomaterials, with a particular focus on natural products and innovative formulations. He has published over 100 peer-reviewed research articles, authored several book chapters, and holds multiple patents related to advanced drug delivery systems. Dr. Reddy also serves as a research coordinator, an active Ph.D. guide, and is on the editorial board and review panels of reputed international journals.
Chenmala Karthika is Postdoctoral Fellow at the National Institute of Health in the USA. She completed her Ph.D. at JSS College of Pharmacy, Ooty, and has published more than 35 national and international research articles in journals of high repute. Over the past five years, her research has focused on cancer and its therapeutic approaches, with an additional interest in aging, COVID-19, and neurodegenerative disorders.
Ali T. Zari is Assistant Professor in the Department of Biological Sciences at the Faculty of Sciences, King Abdulaziz University in Jeddah, Saudi Arabia. He obtained his Bachelor of Science in Biology in 2007 from King Abdulaziz University and completed his Master of Science in Biology in 2014 at Laurentian University in Canada. He earned his Ph.D. in biomolecular sciences from Laurentian University in Canada in 2019. Dr. Zari’s research interests encompass the examination of the effects of medicinal plants and their bioactive components on various cancer cells and other diseases using biomolecular techniques in vitro and in vivo to investigate their potential effectiveness as pharmaceutical sources. Additionally, he investigates the potential benefits and risks of using nanomaterials for therapeutic purposes. Dr. Zari is also involved in in silico prediction of cancer inhibitors and protein modeling for antitumor activity. He has diverse teaching experiences at the graduate and postgraduate levels in the fields of general biology, molecular biology, cell biology, natural products, and animal physiology at King Abdulaziz University.
Gowthamarajan Kuppusamy is Professor and Head, Department of Pharmaceutics (DST-FIST Sponsored), JSS College of Pharmacy, Ooty (JSS Academy of Higher Education & Research, Mysuru). He holds M.Pharm (1996) and Ph.D. (2007) degrees from the Tamil Nadu Dr. MGR Medical University, Chennai. With over two decades of academic and research experience, he has developed industry relevant academic programs and led collaborative projects in intranasal and nanotechnology-based drug delivery. His current focus is on optimized and personalized drug delivery systems. He has guided over 50 PG and 18 Ph.D. scholars. He has executed several government-funded projects in areas such as Alzheimer’s disease, colorectal cancer, cardiovascular diseases, and space medicine, receiving grants from DST-SERB, AICTE, ICMR, DBT, and SPARC. He has played a significant role in technology transfers and serves as a consultant for multiple pharmaceutical industries. Dr. Gowthamarajan has been consistently listed among the top 2% scientists globally by Stanford University and Elsevier for the past three consecutive years (2022–2024). He has over 150 peer-reviewed publications and 23 patents and is a member of national academic bodies, editorial boards, and regulatory committees.
