This reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and aetiology of asthma. It explores strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways and identify disease-specific targets to reduce the induction, progression, and exacerbation of disease.
"…Editors Eissa and Huston have compiled an impressive author list, numbering > 100, including many of the most well-known asthma clinicians and researchers, each addressing subjects with which they are the most expert."
Pathophysiology of airway inflammation in asthma, Paula J. Busse and William W. Busse; primary human lung cells in the evaluation of airway determination, Tannishia Goggans and Serpil C. Erzurum; airway pH homeostasis in asthma and other inflammatory lung diseases, John Hunt and Benjamin Gaston; monitoring of exhaled breath to assess airway inflammation in asthma, Peter J. Barnes; the modulatory effects of carbon monoxide on the inflammatory response, Francis Whalen, Augustine M.K. Choi, and Jigme M. Sethi; reactive nitrogen species and tyrosine nitration in airway inflammation, Albert van der Vliet, Jason P. Eiserich, Brian Morrissey, and Carroll E. Cross; S-nitrosothiols in lung inflammation, Harvey E. Marshall, Loretta G. Que, Jonathan S. Stamler and Benjamin Gaston; contribution of different nitric oxide synthase isoforms to allergen-induced airway hyperresponsiveness and inflammation - lessons from murine models, George T. DeSanctis and El-Bdaoui Haddad; molecular mechanisms of increased nitric oxide airway inflammation, Weiling Xu and Serpil C. Erzurum; regulation of nitric oxide synthesis by inducible nitric oxide synthase, Pawel Kolodziejski and N. Tony Eissa; novel strategies for selective inhibition of inducible nitric oxide synthase, John F. Parkinson; leukocyte recruitment in allergic pulmonary inflammation, Bruce S. Bochner; neutrophil emigration in the lungs, Claire M. Doerschuk; dendritic cells , A. Karolina Palucka and Jacques Banchereau; the roles of mast cells in airway hyper-reactivity, inflammation and remodelling and immunoregulation in asthma, John L. Faul and Stephen J. Galli; mast cells exocytosis in airway inflammation, Roberto Adachi, Rupesh Nigam, and Burton Dickey. (Part contents).