Thiamine Catalytic Mechanisms in Normal and Disease States

Chemical Intermediates in Catalysis by Thiamine Diphosphate, Perry A. Frey; Mechanistic and Structural Studies on Thiamine Biosynthetic Enzymes, Tadhg P. Begley and Steven E. Ealick; Studies on the Structure and Function of Thiamine Pyrophosphokinase, Jing-Yuan Liu, David E. Timm, Robert A. Harris and Thomas D. Hurley; New Perspectives on the Cellular Role of Thiamine Triphosphate and Thiamine Triphosphatase, Lucien Bettendorff and Pierre Wins; How Thiamine Works in Enzymes - Time-Resolved NMR Snapshots of ThDP-Dependent Enzymes in Action, Kai Tittmann, Ralph Golbik, Kathrin Uhlemann, Ludmila Khailova, Mulchand Patel, Frank Jordan, David Chipman, Ronald G. Duggleby and Gerhard H bner; Thiamine-Dependent Enzymes as Catalysts of C-C-Bonding Reactions - The Role of Orphan Enzymes, Michael Muller and Georg A. Sprenger; Ligand-Induced Conformational Changes in Thiamine Diphosphate-Dependent Enzymes - Comparison Between Crystal and Solution Structures, Stephan Konig, Michael Spinka, Erik Fiedler, Georg Wille, Johanna Brauer, Michel H.J. Koch and Dmitri I. Svergun; Enantioselective Synthesis of Hydroxy Ketones via Benzaldehyde Lyase- and Benzoylformate Decarboxylase-Catalyzed C-C Bond Formation, Bettina Lingen, Andreas Liese and Michael Muller; Benzoylformate Decarboxylase - Lessons in Enzymology, Michael J. McLeish, George L. Kenyon, Elena S. Polovnikova, Asim K. Bera, Natalie L. Anderson and Miriam S. Hasson; New Concept on the Nature of the Induced Absorption Band of Holotransketolase, Marina V. Kovina, Irina A. Bykova, Olga N. Solovjeva, Ludmilla E. Meshalkina and German A. Kochetov; Structure of the a-Carbanion/Enamine Reaction Intermediate in the Active Site of Transketolase, Determined by Kinetic Crystallography, Tatyana Sandalova, Erik Fiedler, Stina Thorell, Ralph Golbik, Stephan Konig and Gunter Schneider; Yeast Pyruvate Decarboxylase - New Features of the Structure and Mechanisms, Frank Jordan, Min Liu, Eduard Sergienko, Zhen Zhang, Andrew Brunskill, Palaniappa Arjunan and William Furey; Solvent and Carbon Kinetic Isotope Effects on Active-Site and Regulatory-Site Variants of Yeast Pyruvate Decarboxylase, Wen Wei, Min Liu, Lan Chen, W. Phillip Huskey and Frank Jordan; Insights into the Mechanism and Regulation of Bacterial Acetohydroxyacid Synthases, David M. Chipman, Ze'ev Barak, Stanislav Engel, Sharon Mendel and Maria Vyazmensky; Structure and Properties of Acetohydroxyacid Synthase, Ronald G. Duggleby, Luke W. Guddat and Siew Siew Pang; Exploring the Substrate Specificity of Benzoylformate Decarboxylase, Pyruvate Decarboxylase, and Benzaldehyde Lyase, Poetra Siegert, Martina Pohl, Malea M. Kneen, Irina D. Pogozheva, George L. Kenyon and Michael J. McLeish; Benzoylformate Decarboxylase - Intermediates, Transition States, and Diversions, Ronald Kluger, Qingyan Hu and Ian F. Moore; Structural and Functional Organization of Pyruvate Dehydrogenase Complexes, Z. Hong Zhou, Lester Reed and James K. Stoops.

Biography

Jordan, Frank; Patel, Mulchand S.