450 pages | 15 B/W Illus.
This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barrier may result in damage to the skin or may alter absorption.
With contributions from over 40 international experts in the field of skin biology, the book presents the central role of the skin barrier to health and disease reviewing;
Toxicology of the Skin is essential reading for drug delivery pharmacologist, formulation scientists, dermatologists, toxicologists, molecular biologists, engineers, surgeons, students and anyone interested in skin irritation and skin absorption.
"…this book is a worthy addition to the Target Organ Toxicology Series. Reading this book has added to my knowledge of toxicity resulting from skin exposure and given me a greater appreciation of key factors, which should be taken into consideration when assessing risk from chemicals which come into contact with the skin… I would not hesitate to recommend it to anyone working in the regulatory field, as a general easy to read general quick reference book."
—The British Toxicology Society Newsletter
Part I: Skin Morphology and Barrier Properties
Structure and function of skin
Barrier function of skin
Skin lipids for barrier function
Tight junctions: a new barrier in the skin?
Basic principles involved in quantifying the dermal absorption of topically applied chemicals
Chemical structure-skin transport relationships
Cutaneous metabolism and active transport in transdermal drug delivery
Epidermal transporters and metabolism during dermal absorption: importance for toxicity
Hair follicle delivery
Part II: Altered Barriers
Structural and functional correlations of skin barrier in health and disease: models and evaluation
Are there differences in stratum structure & function in different racial skin types?
Skin absorption through a comprised skin barrier
The stratum corneum in aged and photo-aged skin
Cosmetics and skin barrier integrity
Sensing the environment
Diseases associated with cutaneous barrier dysfunction: Basic science aspects, clinical perspectives
Skin surfactant proteins: presence & potential defense functions
Part III: Methods of Delivery
Liposomes as promising tools for the skin delivery & protection of damaged skin
Applications of microneedle technology to transdermal drug delivery
Active transdermal drug delivery
Part IV: Skin Toxicity
Potential arsenic exposure through dermal penetration
Dermal absorption and cutaneous toxicity of metalworking fluids
Cutaneous bromine exposure: An overview and insight into post-exposure molecular responses
Effects of dermal exposure to jet fuel
Sulfur mustard toxicity