Toxicology of the Skin: 1st Edition (Hardback) book cover

Toxicology of the Skin

1st Edition

By Nancy A. Monteiro-Riviere

CRC Press

450 pages | 15 B/W Illus.

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Hardback: 9781420079173
pub: 2010-02-17
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This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barrier may result in damage to the skin or may alter absorption.

With contributions from over 40 international experts in the field of skin biology, the book presents the central role of the skin barrier to health and disease reviewing;

  • The skin’s anatomy and physiology, with focus on the stratum corneum as a barrier to foreign substances.
  • Dermal absorption, cutaneous metabolism, and epidermal transporters.
  • Altered barriers, racial skin types, aged skin, photoaged skin, cosmetics and skin sensitization.
  • Modern approaches to drug delivery across the skin barrier, including liposomes, microneedle technology, active and passive transdermal delivery.
  • Examples and case studies of chemical toxicity after topical exposures ranging from arsenic, metal working fluids, bromine, jet fuel, sulfur mustard and including the emerging area of nanomaterial penetration.

Toxicology of the Skin is essential reading for drug delivery pharmacologist, formulation scientists, dermatologists, toxicologists, molecular biologists, engineers, surgeons, students and anyone interested in skin irritation and skin absorption.


"…this book is a worthy addition to the Target Organ Toxicology Series. Reading this book has added to my knowledge of toxicity resulting from skin exposure and given me a greater appreciation of key factors, which should be taken into consideration when assessing risk from chemicals which come into contact with the skin… I would not hesitate to recommend it to anyone working in the regulatory field, as a general easy to read general quick reference book."

The British Toxicology Society Newsletter

Table of Contents

Part I: Skin Morphology and Barrier Properties

Structure and function of skin

Barrier function of skin

Skin lipids for barrier function

Tight junctions: a new barrier in the skin?

Basic principles involved in quantifying the dermal absorption of topically applied chemicals

Chemical structure-skin transport relationships

Cutaneous metabolism and active transport in transdermal drug delivery

Epidermal transporters and metabolism during dermal absorption: importance for toxicity

Hair follicle delivery

Part II: Altered Barriers

Structural and functional correlations of skin barrier in health and disease: models and evaluation

Are there differences in stratum structure & function in different racial skin types?

Skin absorption through a comprised skin barrier

The stratum corneum in aged and photo-aged skin

Cosmetics and skin barrier integrity

Sensing the environment

Skin Sensitization

Diseases associated with cutaneous barrier dysfunction: Basic science aspects, clinical perspectives

Skin surfactant proteins: presence & potential defense functions

Part III: Methods of Delivery

Liposomes as promising tools for the skin delivery & protection of damaged skin

Applications of microneedle technology to transdermal drug delivery

Active transdermal drug delivery

Part IV: Skin Toxicity

Nanomaterial penetration

Potential arsenic exposure through dermal penetration

Dermal absorption and cutaneous toxicity of metalworking fluids

Cutaneous bromine exposure: An overview and insight into post-exposure molecular responses

Effects of dermal exposure to jet fuel

Sulfur mustard toxicity

About the Author/Editors

Nancy Ann Monteiro-Riviere, Ph.D. is a Professor of Investigative Dermatology and Toxicology at the Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University (NCSU) as well as a Professor in the Joint Department of Biomedical Engineering at UNC-Chapel Hill/NCSU and Research Adjunct Professor of Dermatology, School of Medicine at UNC Chapel Hill. She received her B.S. in Biology from Stonehill College, M.S. and Ph.D. in Anatomy and Cell Biology from Purdue University and a postdoctoral fellowship in toxicology at CIIT in Research Triangle Park, NC. She was past-President of both the Dermal Toxicology and In Vitro Toxicology Specialty Sections of the National Society of Toxicology. Dr. Monteiro-Riviere is a Fellow of the Academy of Toxicological Sciences and American College of Toxicology. She serves as Associate Editor for Wiley Interdisciplinary Reviews in Nanomedicine and Nanobiotechnology and serves on seven toxicology editorial boards. She also serves on several national panels relating to dermal penetration and absorption, including many in nanotoxicology, such as the National Academies of Science Research Council to Review the Federal Strategy to Address Environmental, Health, and Safety Research Needs for Engineered Nanoscale Materials. She has published over 230 manuscripts and book chapters in the field of skin biology and toxicology and is also Co-Editor of the book "Nanotoxicology: Characterization and Dosing and Health Effects".

About the Series

Target Organ Toxicology Series

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Dermatology
MEDICAL / Pharmacology
MEDICAL / Pharmacy