Of the multitude of toxins known and the enormous variety of effects they cause, of particular interest are those that influence signal transduction. Intercellular communication by chemical signals is essential for the functioning of multicellular organisms. Many toxins exert their biological effects by interfering with the signal transduction initiated by these chemicals (hormones, transmitters, growth factors, and other mediators). Up-to-date information is provided by outstanding experts, who discuss the molecular mechanisms involved in the action of many toxins, as well as the use of toxins as informative tools with which to study signal transduction and their potential therapeutic usage.
This volume contains useful information for the experimentalist interested in toxins or in signal transduction, as well as for the reader interested in gaining a comprehensive overview of the field.
The Cellular and Molecular Mechanisms of Toxin Action series will include monographs on signal transduction, secretory systems, cytoskeleton, selective neurotoxicity of natural, recombinant and chimeric toxins giving a broader emphasis on the mechanism of action, structure-function relationship, and use of toxins as research tools and their therapeutic applications.
1. Overview of Signal Transduction 2. On the Toxin Binding Site of the Nicotine Acetylcholine Receptor 3. Muscarinic Toxins and Muscarinic Acetylcholine Receptors 4. Sodium Channels as Targets for Neurotoxins 5. Ionophore Polypeptide Toxins and Signal Transduction 6. Activation of Cholera Toxin by ADP-Ribolysation Factors (ARFs), 20-kDA Guanine Nucleotide-Binding Protein Components of the Vesicular Trafficking System 7. Diphtheria Toxin Mutations: Their Role in Structure-Function Studies 8. Adenylate Cyclase Toxin from Bordetella Pertussis: Modes of Interaction With Cells 9. Phosphoinositide- Specific Phospholipase C and Toxins 10. Protein Kinase C: Activators and Inhibitors