518 Pages
by
CRC Press
Of the multitude of toxins known and the enormous variety of effects they cause, of particular interest are those that influence signal transduction. Intercellular communication by chemical signals is essential for the functioning of multicellular organisms. Many toxins exert their biological effects by interfering with the signal transduction initiated by these chemicals (hormones, transmitters,... Read more
1. Overview of Signal Transduction 2. On the Toxin Binding Site of the Nicotine Acetylcholine Receptor 3. Muscarinic Toxins and Muscarinic Acetylcholine Receptors 4. Sodium Channels as Targets for Neurotoxins 5. Ionophore Polypeptide Toxins and Signal Transduction 6. Activation of Cholera Toxin by ADP-Ribolysation Factors (ARFs), 20-kDA Guanine Nucleotide-Binding Protein Components of the Vesicular Trafficking System 7. Diphtheria Toxin Mutations: Their Role in Structure-Function Studies 8. Adenylate Cyclase Toxin from Bordetella Pertussis: Modes of Interaction With Cells 9. Phosphoinositide- Specific Phospholipase C and Toxins 10. Protein Kinase C: Activators and Inhibitors
Biography
Yehuda Gutman
