Transferrin, a glycoprotein synthesized by all vertebrates, acts as the vehicle for transporting iron and possibly other transition elements between different sites in the body. Transferrin has other biological roles, including a mitiotic signal and an antibacterial agent. The structure, function, evolution, regulation of synthesis, cellular uptake and recycling, and genetic variablity of human and other animal transferrins are discussed.
The Chemistry and Biology of Iron. Iron Metabolism in Man. The Siderophilin Family. Transferrin Structure and Iron Binding. Transferrin Binding of Elements Other Than Iron. The Transferrin Gene-Structure, Regulation and Tissue Expression. The Transferrin Receptor and the Cellular Uptake of Iron. Genetic Variation of Human Transferrin. Animal Transferrins-Structure, Properties and Genetic Variation. Human Transferrin-Selected Clinical and Pathological Aspects. Index.