Translational Research in Traumatic Brain Injury  book cover
1st Edition

Translational Research in Traumatic Brain Injury

ISBN 9781466584914
Published October 9, 2015 by CRC Press
436 Pages 9 Color & 34 B/W Illustrations

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Book Description

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow.

Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas:

  • Epidemiology
  • Pathophysiology
  • Diagnosis
  • Current treatment strategies and sequelae
  • Future therapies

Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Table of Contents

Peter Leo and Michael McCrea

Sport-Related Traumatic Brain Injury

Michael Clark and Kevin Guskiewicz

Diffuse Axonal Injury

Erik Su and Michael Bell

Blood-Brain Barrier Pathophysiology following Traumatic Brain Injury

Lulit Price, Christy Wilson, and Gerald Grant

Cellular and Molecular Mechanisms of Secondary Neuronal Injury following Traumatic Brain Injury

Kamesh Krishnamurthy and Daniel Laskowitz


Finnian Hanrahan and Matthew Campbell

Neurosteroids and Traumatic Brain Injury: Translating Biomarkers to Therapeutics; Overview and Pilot Investigations in Iraq and Afghanistan Era Veterans

Christine E. Marx, Jennifer C. Naylor, Jason D. Kilts, Charlotte E. Dunn, Larry A. Tupler, Steven T. Szabo, Bruce P. Capehart, Rajendra A. Morey, Lawrence J. Shampine, and VA Mid-Atlantic MIRECC Workgroup

Neuroplasticity after Traumatic Brain Injury

YouRong Sophie Su, Annand Veeravagu, and Gerald Grant

Genetic Influences in Traumatic Brain Injury

Ellen R. Bennett, Karin Reuter-Rice, and Daniel T. Laskowitz

Modeling Post-Traumatic Epilepsy for Therapy Development

Giulia Curia, Clifford L. Eastman, John W. Miller, and Raimondo D’Ambrosio

Translational Principles of Neuroprotective and Neurorestorative Therapy Testing in Animal Models of Traumatic Brain Injury

Edward D. Hall

Biomarkers of Traumatic Brain Injury and Their Relationship to Pathology

Jin Zhang, Vikram Puvenna, and Damir Janigro

Advanced Neuroimaging of Mild Traumatic Brain Injury

Inga K. Koerte, Jakob Hufschmidt, Marc Muehlmann, Alexander P. Lin, and Martha E. Shenton

Epilepsy after Traumatic Brain Injury

Kan Ding, Puneet K. Gupta, and Ramon Diaz-Arrastia

Intracranial Pressure Monitoring and Management

Peter Le Roux

Post-Traumatic Stress Disorder: Relationship to Traumatic Brain Injury and Approach to Treatment

Jonathon R. Howlett and Murray B. Stein

Traumatic Brain Injury and Potential for Neuromodulation

Shivanand P. Lad

Enhanced Functional Outcome from Traumatic Brain Injury with Brain-Machine Interface Neuromodulation: Neuroprosthetic Scaling in Relation to Injury Severity

Dennis A. Turner

Neurocognitive and Psychiatric Symptoms following Mild Traumatic Brain Injury

Wesley R. Cole and Jason M. Bailie

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Edited by

Daniel Laskowitz, MD, MHS, professor of neurology, anesthesiology & neurobiology; and director, Neurovascular Laboratories, Duke University Medical Center, Durham, North Carolina, USA

Gerald A. Grant, MD, FACS, division chief, Pediatric Neurosurgery; vice chair for pediatric neurosurgery and associate program director; and associate professor, Department of Neurosurgery; Stanford University/Lucile Packard Children's Hospital, California, USA