The emphasis of this book is on mechanisms/pathways regulating the expression and actions of classical and novel tumor angiogenesis regulators, their underlying biology as well as anti-angiogenic drugs currently in use to fight different cancers. This book provides an insight on how factors such as obesity, diabetes and other metabolic disorders can influence the development and growth of cancer. It will be of interest not only to oncologists but also to a wide range of medical practitioners and researchers.
Table of Contents
VEGF Signaling in Normal and Tumor Angiogenesis, Evangelia Pardali, Rinesh Godfrey and Johannes Waltenberger
Regulation of Angiogenesis via Notch Signaling in Human Malignancy, Shanchun Guo, Mingli Liu, Lily Yang, Guangdi Wang and Ruben R. Gonzalez-Perez
Endothelial and Cancer Stem Cell Regulation of Tumor Angiogenesis, Mingli Liu, Lily Yang, Shanchun Guo and Ruben R. Gonzalez-Perez
Differential Activation of Macrophages in Tumors: Roles in the Regulation of Tumor Development and Angiogenesis, Shalini P. Outram and S. Joseph Leibovich
Paracrine and Autocrine Control of Endothelial Cell Function by Inflammatory and Bioactive Lipid Mediators: Relevance for Tumor Angiogenesis, Charlotte E Farrar, Alexandra McSloy, Elena Garonna and Caroline PD Wheeler-Jones
Tumor Angiogenesis Regulators in Breast Cancer: Does Race matter? Laronna S. Colbert and Taliaferro-Smith
Regulation of Tumor Angiogenesis by Non-Classical Factors: Peptide and Protein Factors, Lipid and Steroid Factors and by Other Novel Small Molecules, Gary L. Sanford, Ravindra Kumar and Tanisha McGlothen
The Role of Cyclooxygenases and Lipoxygenases in the Regulation of Tumor Angiogenesis, Graham Pidgeon
Cathepsins and Other Proteases in Tumor Angiogenesis, Manu O. Platt and Jerald E. Dumas
Krüppel-like factor 5 (KLF5) and Tumor Angiogenesis, Rohinton S. Tarapore and Yizeng Yang
Signatures of Heightened Angiogenesis in Gynecologic Cancers: The Promise of Innovative Therapies, Whitfield Growdon, Rosemary Foster, Leslie Bradford and Bo R. Rueda
Obesity, Diabetes and Metabolic Syndrome Impact on TUMOR ANGIOGENESIS, João Incio and Raquel Soares
Gonzalez-Perez, Ruben R.; Rueda, Bo R.