Best Seller!
Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach, 1st Edition (Hardback) book cover

Understanding Drug Release and Absorption Mechanisms

A Physical and Mathematical Approach, 1st Edition

By Mario Grassi, Gabriele Grassi, Romano Lapasin, Italo Colombo

CRC Press

648 pages | 167 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9780849330872
pub: 2006-12-26
SAVE ~$32.25
Currently out of stock
$215.00
$182.75
x
eBook (VitalSource) : 9780429129278
pub: 2006-12-26
from $28.98


FREE Standard Shipping!

Description

Demand for better reliability from drug delivery systems has caused designers and researchers to move away from trial-and-error approaches and toward model-based methods of product development. Developing such models requires cross-disciplinary physical, mathematical, and physiological knowledge. Combining these areas under a single cover, Understanding Drug Release and Absorption Mechanisms builds a firm understanding ofall elements needed to conceive, build, and implement successful models of drug release.

Written by experts with broad industrial and academic experience, this book discusses the underlying physical principles, shows how to build mathematical models based on these principles, and finally compares the resulting models with experimental results. The authors begin by introducing the basics of modeling, physiological details of gastrointestinal and dermal absorption pathways, rheology, mass transport and thermodynamics, dissolution and partitioning, as well as size effects on the dissolution of crystallites. From this baseline, the authors explore applications in drug release from various delivery systems, specifically matrix systems, microemulsions, and permeability through membranes.

Working systematically from theory to working models, Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach demonstrates the steps involved in designing, building, and implementing realistic and reliable models of drug release without unrealistically simplifying the theoretical parameters.

Table of Contents

Mathematical Modeling

Introduction

Model Building

Model Fitting

Models Comparison

Conclusions

References

Gastrointestinal Tract

Macro- and Microscopic Anatomy of the Gastrointestinal Tract

Intestinal Absorption

Human and Animal GI Tract: A Comparison

Skin

Anatomy

Skin Delivery Strategies

Animal Model of Skin Delivery

References

Rheology

Introduction

Viscosity and Newtonian Fluids

Shear-Dependent Viscosity and Non-Newtonian Fluids

Shear Flows

Not Only Viscosity: Normal Stress Differences and Other Material Functions

Extensional Flows and Complex Flows

Time-Dependence: Thixotropy and Viscoelasticity

Linear Viscoelasticity

Rheological Properties and Structural Features

Conclusive Considerations on Rheology Applications to Drug Delivery Systems

References

Mass Transport

Introduction

Thermodynamic Concepts

Kinetics

Fick’s Equation

Effect of Initial and Boundary Conditions

Conclusions

References

Drug Dissolution and Partitioning

Introduction

Dissolution

Partitioning

Dissolution and Partitioning

Conclusions

References

Dissolution of Crystallites: Effects of Size on Solubility

Introduction

Thermodynamic Concepts

Experimental Methods and Limitations

Conclusions

References

Drug Release from Matrix Systems

Introduction

Matrices

Mathematical Modeling

Conclusions

References

Drug Release from Microemulsions

Introduction

Microemulsions: Structure

Microemulsions: Thermodynamics

Microemulsions: Experimental Characterization

Microemulsions and Drug Release

Conclusions

References

Drug Permeation through Membranes

Introduction

Synthetic Membranes

Biological Membranes

Conclusions

References Index

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
MED071000
MEDICAL / Pharmacology
SCI013060
SCIENCE / Chemistry / Industrial & Technical