Vascular Control of Hemostasis
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Hemostasis represents a group of balanced activities that keep the blood flowing It is a complete response system which has developed to guarantee blood fluidity and to limit blood loss after wounding, and adapts after exposure to infectious micro-organisms The failure of this control system causes ischemia, severe damage to the distal tissues and, ultimately, death This book provides an up-to-date and comprehensive account of the control of hemostasis by vascular cells It is an indispensable guide for researchers in hemostasis and vascular biology, from the post-graduate level onwards It will also be of great interest to clinicians in vascular medicine and cardiology Topics covered include: hemostatic properties of the vessel wall; anticoagulant properties of the vessel wall; other aspects of coagulation; and changes in vascular hemostatic properties
Table of Contents
1. The Vessel Wall and Hemostasis 2. Tissue-Type Plasminogen Activator and the Vessel Wall: Synthesis, Storage, and Secretion 3. Anticoagulant Properties of Vascular Cells: Thrombomodulin and Protein C Activation Pathway 4. The Heparan Sulfate-Antithrombin Pathway: A Natural Anticoagulant Mechanism of the Blood Vessel Wall 5. The Role of Annexins in Vascular Hemostasis 6. Vessel Wall Activation of the Blood Coagulation System 7. Properties and Biosynthesis of Von Willebrand Factor: A Critical Review 8. Regulation of Platelet-Rich Thrombus Formation by the Endothelium 9. Platelet Adhesion 10. Vitronectin as the Link between Protease Cascades and Cell Adhesion in Hemostasis 11. Synthesis and Localization of PS-1 in the Vessel Wall 12. The Role of Plasminogen Activators in Vascular Pericellular Proteolysis 13. Evaluation of the Role of Fibrinolytic System in Transgenic Animals 14. Environmental Pertubation of Endothelium: Modulation of Vascular Properties by Hypoxia, Hyperglycemia, and Tumor-Derived Cytokines 15. Pathogenesis of the Altered Vascular Hemostasis Properties in Sepsis: In Vivo Studies 16. Viral Induction of Endothelial Cell Procoagulant Activity