Vitamin D: Oxidative Stress, Immunity, and Aging, 1st Edition (e-Book) book cover

Vitamin D

Oxidative Stress, Immunity, and Aging, 1st Edition

Edited by Adrian F. Gombart

CRC Press

462 pages

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Description

Vitamin D insufficiency/deficiency is a worldwide, public health problem in both developed and developing countries. Rickets among infants has reemerged. Low levels of vitamin D are associated with increased risk and mortality from cancer. At the same time, the beneficial effects of vitamin D on a host of conditions have recently been discovered. F

Table of Contents

Vitamin D: An Overview. Vitamin D: A Fountain of Youth in Gene Regulation. Vitamin D Receptor: Genomic and Epigenomic Effects. Vitamin D Analogs and Their Clinical Uses. Extrarenal CYP27B1 and Vitamin D Physiology. Oxidative Stress. Vitamin D and Oxidative Stress. Vitamin D3 Upregulated Protein 1 (VDUP1): Roles in Redox Signaling and Stress-Mediated Diseases. Vitamin D and Its Role in Photoprotection of the Skin. Vitamin D and Adipose Tissue: 1a, 25-Dihydroxyvitamin D3 (Calcitriol) Modulation of Energy Metabolism, Reactive Oxygen Species, and Inflammatory Stress. Membrane Receptors for Vitamin D Metabolites and the Role of Reactive Oxygen Species. Immunity and Disease. Vitamin D and Human Innate Immunity. Vitamin D and Autoimmune Disease. Vitamin D: Anti-Inflammatory Actions to Prevent and Treat Diseases. Vitamin D and Infection. Aging. Potential Role of Vitamin D and Fibroblast Growth Factor 23-Klotho System in Aging. Vitamin D and Cardiovascular Disease. Vitamin D, Aging, and Chronic Diseases. Vitamin D: Defending the Aging Nervous System. Index.

About the Editor

Adrian F. Gombart received a Ph.D. degree in microbiology from the University of Washington. For many years, he was an assistant and associate professor at Cedars-Sinai Medical Center and the David Geffen School of Medicine at the University of California, Los Angeles, in the Department of Biomedical Sciences and Division of Hematology and Oncology. He is currently a principal investigator in the Linus Pauling Institute and an associate professor in the Department of Biochemistry and Biophysics at Oregon State University. Dr. Gombart is a member of the American Society for Hematology and the Society for Leukocyte Biology. Dr. Gombart's research interests focus on the role of vitamin D in the innate immune response against infection. His laboratory studies the regulation of antimicrobial peptide gene expression by vitamin D and other nutritional compounds. He was recognized for his contributions to the field of vitamin D and immunity, with a Young Investigator Award from the Vitamin D Workshop in 2005.

Subject Categories

BISAC Subject Codes/Headings:
MED032000
MEDICAL / Geriatrics
MED060000
MEDICAL / Nutrition
SCI017000
SCIENCE / Life Sciences / Cytology