The Chromosomal Imbalance Theory of Cancer

The Autocatalyzed Progression of Aneuploidy is Carcinogenesis

By David Rasnick

© 2012 – CRC Press

330 pages | 14 Color Illus. | 3 B/W Illus.

Purchasing Options:
Hardback: 9781578087372
pub: 2011-12-19
US Dollars$132.95
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About the Book

Exploring the chromosomal imbalance (aneuploidy) theory of cancer, this volume describes how cancer is initiated and why progression takes years to decades. It clarifies why cancer cells often become drug resistant, provides objective, quantitative measures for detecting cancer and monitoring its progression, and suggests non-toxic strategies of cancer therapy and prevention. The book posits that the autocatalyzed progression of aneuploidy is carcinogenesis. The clarity and unifying simplicity of the theory of chromosomal imbalance has the potential to fundamentally alter the course of cancer research, prevention, diagnosis and treatment.

Table of Contents

Introducing Cancer

Boveri’s Theory of Cancer was Ahead of its Time

Aneuploidy theory "Got Lost"

Genesis of "The Enemy Within"?

Clonal cancer

Tumorigenic retroviruses

Dominate oncogenes

Tumor suppressor genes

Driver genes

Gene Mutation Theory of Cancer

"Carcinogens are mutagens

Retroviral oncogenes

Are "cellular oncogenes" like retroviral oncogenes?

Updated gene mutation theory is popular but unconfirmed

The Chromosomal Imbalance Theory of Cancer

Heuristic explanation of how chromosomal imbalance (and not gene mutation) generates cancer phenotypes

Aneuploidy causes chromosomal instability—the hallmark of cancer

Cancer is a progressive somatic aneuploidy Syndrome

Quantitative analysis of how aneuploidy generates new cellular phenotypes

Theory of Chromosomal Imbalance Solves Mysteries and Paradoxes

Carcinogenesis is dependent on aneuploidy and not mutation

Aneuploidy causes the Warburg effect by increasing ATP demand

Balanced mitotic forces and species-specific sequential chromatid separation may govern the rate of transformation

Cancer vaccine is very unlikely

"Cancers are a genuine type of species"

New Perspectives for Cancer Prevention, Diagnosis and Therapy

International regulation of aneuploidy-inducing agents

Cancer detection

Cancer therapy

Conclusion

Subject Categories

BISAC Subject Codes/Headings:
MED027000
MEDICAL / Endocrinology & Metabolism
SCI017000
SCIENCE / Life Sciences / Cytology
SCI029000
SCIENCE / Life Sciences / Genetics & Genomics