A Guide to Pharmaceutical Particulate Science: 1st Edition (Hardback) book cover

A Guide to Pharmaceutical Particulate Science

1st Edition

By Anthony J. Hickey, Timothy M. Crowder, Margaret D. Louey, Norman Orr

CRC Press

256 pages | 19 B/W Illus.

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pub: 2003-03-12
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Description

The pharmaceutical applications of powder technology have long been recognized. Yet while many books focus on aspects of powder formation and behavior, there has been no text that explores the power of particulate science in the design, manufacture, and control of quality medicines. Until now. A Guide to Pharmaceutical Particulate Science discusses key principles of particulate science and their practical applications.

The authors cover particulate material, its form and production, sampling from bodies of powder, particle size descriptors and statistics, behavior of particles, instrumental analysis, particle size measurement and synergy of adopted techniques, physical behavior of a powder, and in vitro and in vivo performance criteria. They draw the components of particulate science into a single concise description of their current and potential uses in product development. Exploring the growth in knowledge of particle properties and the variety of technological advances in particle manufacture, A Guide to Pharmaceutical Particulate Science gives readers the tools they need to grasp the science and its use in the industry.

Reviews

"[This book] treats … various topics … in a logical sequence. The references are extensive and provide the reader with valuable guidance to the relevant literature, especially in the pharmaceutical sciences. … [T]his book provides an excellent foundation for a didactic course in particulate science or powder technology. … [It] will likewise be valuable to scientists who are eager to acquire basic knowledge of particulate science in pharmaceutics."

- Pharmaceutical Research

"A useful guide to the subject…the volume covers a gap in the existing literature and should be on the shelves of company libraries."

- Organic Process Research and Development Journal

Table of Contents

INTRODUCTION AND OVERVIEW

Situation Analysis

Quality of Published Data on Particle Size in Pharmaceuticals

The Future of Crystal Engineering

Chemistry and Pharmacy Regulatory Submissions

Misconceptions and Misunderstandings of Particulate Science

Powerful Methods Complementary to Particle Sizing

Integration of Particle Sizing Methods with their In-Use Situation

Adjacencies and Interactions Between Particles

Lessons from Other Industries

Pharmaceutical Particulate Science as a Core Educational Requirement

Particle Characterization and its Impact on Regulatory Submissions from Formulation through Toxicology and Efficacy

Conclusion

PARTICULATE SYSTEMS: MANUFACTURE AND CHARACTERIZATION

States of Matter

Crystalline Solids

Crystal Symmetry

Euler's Relationship

Crystal Systems

Miller Indices

Space Lattices

Solid State Bonding

Isomorphs and Polymorphs

Enantiomorphs and Racemates

Crystal Habit

Crystal Imperfections

Methods of Particulate Production

Particulate Systems

Conclusion

SAMPLING AND MEASUREMENT BIASES

Sampling Strategies

Statistical Analyses

Sampling Techniques

Segregation

Sampling

Sampling Errors

Preparation Errors

Particle Size Measurements Errors

Conclusions

PARTICLE SIZE DESCRIPTIONS AND STATISTICS

Particle Size Descriptions

Particle Size Statistics

Mathematical Distributions

Applications

Conclusion

BEHAVIOR OF PARTICLES

Physical Properties

Particle Adhesion

Particle Motion in Bulk Powders

Particle Motion in Gaseous Dispersions

Particle Motion in Liquid Media

Conclusion

INSTRUMENTAL ANALYSIS

Direct Imaging

Indirect Imaging

Physical Methods of Particle Size Separation

Approaches to Calibration

Conclusions

METHODS OF PARTICLE SIZE MEASUREMENT AND THEIR IMPORTANCE FOR SPECIFIC APPLICATIONS (INSTRUMENT SYNERGY)

An Essay on Measures of Diameters

Conclusion

PARTICLE SIZE BEHAVIOR AND PHYSICAL BEHAVIOR OF A POWDER

Selection of the Appropriate Particle Size Expression

Powder Flow and Mixing

Dispersion

Granulation and Compression

Conclusion

CLINICAL EFFECT OF PHARMACEUTICAL PARTICULATE SYSTEMS

Oral Delivery

Parenteral Delivery

Respiratory Delivery

Nasal Delivery

Transdermal and Topical Delivery

Ocular Delivery

Otic Delivery

Buccal and Sublingual Delivery

Rectal Delivery

Vaginal Delivery

Conclusions

GENERAL CONCLUSIONS

REFERENCES

INDEX

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
SCI013000
SCIENCE / Chemistry / General