1st Edition

Carnitine Metabolism and Human Nutrition

Edited By Benjamin T. Wall, Craig Porter Copyright 2014
    186 Pages 11 B/W Illustrations
    by CRC Press

    Carnitine Metabolism and Human Nutrition offers a contemporary and in-depth look at the biological effects of carnitine metabolism and its application to clinical and sports nutrition, based on decades of robust scientific enquiry. It gathers and distills key results of the last 20 years of carnitine research to provide an invaluable reference tool for students, researchers, and clinicians.

    This book addresses the importance of carnitine in skeletal muscle fuel metabolism, the complexities and importance of muscle carnitine transport, and the metabolic insight that has been gained from experiments manipulating muscle carnitine stores. The authors cover the potential application of carnitine supplementation in specific clinical populations and the role of carnitine as an ergogenic aid for athletes. They also provide a comprehensive mechanistic overview of skeletal muscle insulin resistance, including the role of carnitine shuttle systems in the metabolic abnormalities associated with obesity and the metabolic syndrome.

    Carnitine Metabolism and Human Nutrition provides you with a comprehensive and up-to-date look at the properties and underlying metabolic biochemistry of carnitine. The book provides contributions from leading international scientists, each a pioneer in their chosen study of carnitine metabolism or its application to human nutrition.

    Section I: Carnitine homeostasis and tissue metabolism

    Carnitine homeostasis in humans
    Peggy Borum

    Carnitine and energy metabolism
    Tariq R. Altamimi and Gary D. Lopaschuk

    Section II: Carnitine transport and metabolism in skeletal muscle

    The role of carnitine in the integration of skeletal muscle fuel metabolism
    Craig Porter

    Skeletal muscle carnitine transport
    Francis B. Stephens

    The metabolic impact of manipulating the muscle carnitine pool
    Benjamin T. Wall

    Section III: Applications of carnitine in human nutrition

    Carnitine metabolism and nutrition in dialysis patients
    Eric P. Brass

    Carnitine metabolism and nutrition in insulin resistance and type 2 diabetes
    Shawna Wicks, Robert Noland, and Randall Mynatt

    Carnitine metabolism and nutrition in peripheral vascular disease
    Giusseppe Maria Andreozzi

    Carnitine as an ergogenic aid for sports performance
    Stuart D.R. Galloway and Elizabeth M. Broad

    Conclusions and future directions
    Craig Porter and Benjamin T. Wall


    Benjamin T. Wall, Craig Porter