Carnitine Metabolism and Human Nutrition offers a contemporary and in-depth look at the biological effects of carnitine metabolism and its application to clinical and sports nutrition, based on decades of robust scientific enquiry. It gathers and distills key results of the last 20 years of carnitine research to provide an invaluable reference tool for students, researchers, and clinicians.
This book addresses the importance of carnitine in skeletal muscle fuel metabolism, the complexities and importance of muscle carnitine transport, and the metabolic insight that has been gained from experiments manipulating muscle carnitine stores. The authors cover the potential application of carnitine supplementation in specific clinical populations and the role of carnitine as an ergogenic aid for athletes. They also provide a comprehensive mechanistic overview of skeletal muscle insulin resistance, including the role of carnitine shuttle systems in the metabolic abnormalities associated with obesity and the metabolic syndrome.
Carnitine Metabolism and Human Nutrition provides you with a comprehensive and up-to-date look at the properties and underlying metabolic biochemistry of carnitine. The book provides contributions from leading international scientists, each a pioneer in their chosen study of carnitine metabolism or its application to human nutrition.
Section I: Carnitine homeostasis and tissue metabolism
Carnitine homeostasis in humans
Carnitine and energy metabolism
Tariq R. Altamimi and Gary D. Lopaschuk
Section II: Carnitine transport and metabolism in skeletal muscle
The role of carnitine in the integration of skeletal muscle fuel metabolism
Skeletal muscle carnitine transport
Francis B. Stephens
The metabolic impact of manipulating the muscle carnitine pool
Benjamin T. Wall
Section III: Applications of carnitine in human nutrition
Carnitine metabolism and nutrition in dialysis patients
Eric P. Brass
Carnitine metabolism and nutrition in insulin resistance and type 2 diabetes
Shawna Wicks, Robert Noland, and Randall Mynatt
Carnitine metabolism and nutrition in peripheral vascular disease
Giusseppe Maria Andreozzi
Carnitine as an ergogenic aid for sports performance
Stuart D.R. Galloway and Elizabeth M. Broad
Conclusions and future directions
Craig Porter and Benjamin T. Wall