750 Pages 780 B/W Illustrations
    by CRC Press

    Circadian rhythms influence most of our life activities, notably getting up and going to sleep every day. This new edition of Circadian Physiology delves into the mechanisms surrounding how these rhythms work, the physiology and biology behind them, and the latest research on this cutting-edge field. The book also discusses a wide variety of practical topics including the prevention of jet lag, management of shift work, sleep disorders, depression, and the optimal times for physical and intellectual activities.

    To facilitate its use as a textbook, the book contains summaries, suggestions for further reading, links to pertinent websites, and exercises at the end of each chapter. It also includes software for data analysis, tutorials, and simulation programs discussed throughout the text. In addition, more than a thousand references have been added, resulting in a total of more than 6000 references.

    The text has been thoroughly updated as a result of major advances in recent years. This edition adds discussion on the anatomical and physiological characterization of photoresponsive ganglionic cells in the mammalian retina, molecular circadian clocks in cells of multiple organs other than the hypothalamus and the pineal gland, and advances in the understanding of post-translational mechanisms in the operation of the molecular clock.

    HISTORY AND METHODS

    Early Research on Circadian Rhythms
    Remote Past
    Twentieth Century
    Current Trends
    Ethics of Animal Research
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Research Methods in Circadian Physiology
    Scientific Method
    Research on Populations and Organisms
    Research on Organs, Cells, and Molecules
    Research on the Environment
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Analysis of Circadian Rhythmicity
    Data Analysis
    Parameters of Circadian Rhythms
    Statistical Significance
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    PHENOMENOLOGY

    Ultradian and Infradian Rhythms
    Environmental Rhythms
    Ultradian Rhythms
    Infradian Rhythms
    Annual Rhythms
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Daily and Circadian Rhythms
    Environmental and Populational Rhythms
    Behavioral Rhythms
    Autonomic Rhythms
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    MECHANISMS


    Endogenous Mechanisms
    Endogenous Rhythmicity
    Inheritance Mechanisms
    Single or Multiple Oscillators
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Photic Environmental Mechanisms
    Nonparametric Theory of Entrainment
    Photic Parameters
    Synthesis and Models
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Nonphotic Environmental Mechanisms
    Nonphotic Entrainment
    Searching for a Common Mechanism
    Separate Food-Entrainable Pacemaker
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Integration of Mechanisms
    Internal Temporal Order
    Ecology and Evolution
    Lifetime Changes
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Homeostasis and Circadian Rhythmicity
    Temperature Regulation
    Sleep, Feeding, and Energy Expenditure
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    PHYSICAL SUBSTRATES

    Receptors
    Sensory Input
    Photic Receptors
    Nonphotic Receptors
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Pacemakers
    Suprachiasmatic Nucleus
    Cellular Processes
    Molecular Processes
    Other Pacemakers
    Summary
    Exercises
    Suggestions for Further Reading
    References

    Afference and Efference
    Afferent Pathways
    Efferent Pathways
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    APPLICATIONS

    Optimal Timing on Earth and in Space

    Patterns of Human Mobility
    Best Time for Sports and Intellectual Activities
    Space Exploration
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Jet-Lag and Shift Work

    Jet-Lag Syndrome
    Shift-Work Malaise
    Daylight-Saving Time
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Human Medicine

    Chronotherapeutics
    Sleep Disorders
    Depression
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Pet Selection and Veterinary Medicine

    Pet Selection
    Veterinary Medicine
    Summary
    Exercises
    Suggestions for Further Reading
    Websites to Explore
    References

    Appendix A: Assessment of Learning


    Appendix B: Dictionary of Circadian Physiology


    Appendix C: Organisms Used


    Biography

    Roberto Refinetti, PhD, is a physiological psychology professor, circadian physiology researcher, and chair of the department of psychology at Boise State University in Idaho, USA. He is also a member of the graduate faculty of the University of Messina (Italy) and was formerly associated with the University of South Carolina, the University of Virginia, the University of Illinois, the University of São Paulo (Brazil), and the University of California at Santa Barbara, where he earned his doctorate. His research program in circadian physiology, which concentrates on the integration of circadian and homeostatic mechanisms, has been funded by the U.S. National Science Foundation and the National Institutes of Health. Professor Refinetti is editor-in-chief of the Journal of Circadian Rhythms and of the interdisciplinary journal Sexuality & Culture.

    Praise for the Previous Edition:

    "... the text remains one of the few comprehensive and scientific introductions to circadian physiology ..."
    —Roy Shephard, MD, PhD, Applied Physiology, University of Toronto, Canada