Functional Lipidomics: 1st Edition (Hardback) book cover

Functional Lipidomics

1st Edition

Edited by Li Feng, Glenn D. Prestwich

CRC Press

352 pages | 111 B/W Illus.

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pub: 2005-09-14
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Lipids play an essential role in cell signaling and subcellular structure. Systematic analysis of the total lipid structure of a cell or organism, the lipodome, can reveal novel avenues of therapeutic intervention and diagnosis. This analysis is best modeled after the lessons learned from proteomics. With contributions from pioneering researchers from the US, Europe, Canada, Japan, and China, Functional Lipidomics introduces lipidomics, explores the current state of the field, and provides a comprehensive background for future groundbreaking work in this burgeoning field.

The first book dedicated to the topic, Functional Lipidomics first defines and introduces the field before delving deeply into the methods, processes, analyses, and research aspects. The book uncovers the biosynthesis, metabolism, and function of fatty acids, acylglyerols, glycerophospholipids, sphingolipids, terpenes, and lipids that complex with proteins. Taking both academic and industrial perspectives, the contributors elaborate upon cutting-edge approaches to lipid analysis, diagnostic approaches using lipid and lipid-binding protein patterns, and the therapeutic significance of targeting proteins involved with the lipid signaling pathway.

Functional Lipidomics elucidates state-of-the-art strategies and techniques that enable us to understand biochemical patterns related to disease states, develop new targets for drug design, and identify important markers of a developmental stage, pathological condition, or disease treatment.

Table of Contents

The LIPID MAPS Approach to Lipidomics

Edward A. Dennis, H. Alex Brown, Raymond A. Deems, Christopher K. Glass, Alfred H. Merrill, Jr., Robert C. Murphy, Christian R.H. Raetz, Walter Shaw, Shankar Subramaniam, David W. Russell, Michael S. VanNieuwenhze, Stephen H. White, Joseph L. Witztum, and John Wooley

LC/MS Methodology in Lipid Analysis and Structural Characterization of Novel Lipid Species

Robert C. Murphy, Jessica Krank, and Robert M. Barkley

Functional Plasticity of Lipid Mediators: The Example of Endocannabinoids

Luciano De Petrocellis, Mario van der Stelt, and Vincenzo Di Marzo

Eicosanoid Lipidomics

Rebecca C. Bowers-Gentry, Raymond A. Deems, Richard Harkewicz, and Edward A. Dennis

Functional Lipidomics: Lysophosphatidic Acid as a Target for Molecular Diagnosis and Therapy of Ovarian Cancer

Janos L. Tanyi, David Crotzer, Judith Wolf, Shuangxing Yu, Yutaka Hasegawa, John Lahad, Kwai Wa Cheng, Makiko Umezu-Goto, Glenn D. Prestwich, Andrew Morris, Robert A. Newman, Edward A. Felix, Rose Lapis, and Gordon B. Mills

Analysis of Lysophospholipids in Human Body Fluids: Comparison of the Lysophospholipid Content in Malignant vs. Nonmalignant Diseases

Yi Jin Xiao and Yan Xu

Functional Lipidomics: Lessons and Examples from the Sphingolipids

Yusuf A. Hannun

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Analysis of Sphingolipids

M. Cameron Sullards and Alfred H. Merrill, Jr.

Methods of Probing Phosphoinositides–Protein Interactions

Li Feng, Colin Ferguson, Paul O. Neilsen, Leena Chakravarty, Piotr W. Rzepecki, and Glenn D. Prestwich

Fishing for Pharmaceutically Relevant phosphoinositide-Binding Proteins Using Chemical Proteomics

Christian Pasquali and Christian Rommel

Phosphoinositide Profiling in Complex Lipid Mixtures

Markus R. Wenk and Pietro De Camilli

Multiplexed Lipid Arrays of Antiimmunoglobulin M–Induced Changes in the Glycerophospholipid Composition of WEHI-231 Cells

Stephen B. Milne, Jeffrey S. Forrester, Pavlina T. Ivanova, Michelle D. Armstrong, and H. Alex Brown

Specific Lipid Alterations in Alzheimer’s Disease and Diabetes: Shotgun Global Cellular Lipidome Analyses by Electrospray Ionization Mass Spectrometry Using Intrasource Separation

Xianlin Han and Richard W. Gross

High-Throughput Lipid Profiling to Identify and Characterize Genes Involved in Lipid Metabolism, Signaling, and Stress Response

Ruth Welti, Jyoti Shah, Steven LeVine, Wynn Esch, Todd Williams, and Xuemin Wang

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
SCIENCE / Life Sciences / Cytology