This book concentrates on the use of biomaterials in nanomedicine. The areas of focus include drug delivery by polymers, lipids, and carbohydrates for the delivery of small molecules, RNA interference, and proteins; the use of nano-proteins such as antibodies and peptides as targeting agents for therapeutics and diagnosis; the use of nanocarrier-based biomaterials for manipulation of stem cells; different aspects of toxicity of nanocarriers (the immune response, liver toxicity, and many more); and success stories of biomaterials that have reached the clinics. The book covers theoretical and experimental analysis of various biomaterials that are used in nanomedicine, research methods and preparation techniques, and several promising applications.
Table of Contents
Biomaterial-Based Particulate Drug Carriers, R. Margalit
Single-Chain Polymer Nanoparticles for Application in Nanomedicine, I. Loinaz
Polyethylene Glycol Polyester Block Co-Polymers: Biocompatible Carriers for Nanoparticulate Drug Delivery, M. L. Forrest
Recent Progress in Polymer Therapeutics as Nanomedicines, R. Satchi-Fainaro
Polysaccharides as Nanomaterials for Therapeutics, D. Peer
RNAi as New Class of Nanomedicines, D. M. Dykxhoorn
Novel RNA Interference (RNAi)-Based Nanomedicines for Treating Viral Infections, P. Kumar
Detection and Description of Tissue Disease: Advances in the Use of Nanomedicine for Medical Imaging, J. L. Dearling and A. B. Packard
Image-Based High-Content Analysis, Stem Cells and Nanomedicines: A Novel Strategy for Drug Discovery, M. Weil
Wrong Resemblance? Role of the Immune System in the Biocompatibility of Nanostructured Materials, T. Vorup-Jensen
Complement Activation, Immunogenicity and Immune Suppression as Potential Side Effects of Liposomes, J. Szebeni and Y. Barenholz
The Story of DOXIL — A Personal Account, Y. Barenholz
Dan Peer is a principal investigator and a senior lecturer and leads an NIH-funded laboratory at Tel Aviv University, Israel. Dan completed his education in biochemistry and biophysics from Tel Aviv University, Israel. From January 2005 to August 2008, he worked at Harvard Medical School. He joined the Department of Cell Research and Immunology, in the Faculty of life sciences at Tel Aviv University in September 2008 to establish the laboratory of nanomedicine. Dan’s research was between the first to demonstrate systemic delivery of RNAi using targeted nano-carriers to the immune system and the first to utilize RNAi for in vivo validation of new drug targets within the immune system. His work was published in premier scientific journals such as Science, Nature Nanotechnology, and PNAS. He is the editor and author of several books in the field of nanomedicine, an associate editor of Journal of Biomedical Nanotechnology, and Frontiers in Biotechnology and Drug Delivery, and on the editorial board of the journals Nanotechnology and Journal of Controlled Release. Dan has received more than 20 awards and honors.
"The nanomedicine revolution has begun. To date, nearly 30 nanotechnology-based products have been approved for clinical use, including liposomal formulations and stealth polymer–drug conjugates. Importantly, the application of nanotechnology to medicine will continue to progressively and fundamentally change the landscape for the pharmaceutical and biotechnology industries. Dan Peer has done an exceptional job bringing together the world’s leading experts to provide an authoritative compilation covering the essential fundamentals and state-of-the-art approaches. The book includes essential methods for preparing nanomaterials, testing the function, and analyzing their safety with relevance to potential regulatory hurdles that may be encountered. This book will undoubtedly become an essential reference for scientists and technologists who aim to characterize, study, and develop clinically relevant and safe nanomedicines."
—Prof. Jeffrey M. Karp - Harvard Stem Cell Institute, USA
"This book is a compendium of recent developments in nanomedicine and advanced drug delivery systems that highlight leading laboratories’ key findings on nanomaterial design, selection, and adverse effects. It is a valuable reference for both students and researchers."
—Prof. S. Moein Moghimi - University of Copenhagen, Denmark