Continuing a long tradition, Lu’s Basic Toxicology, Seventh Edition, combines relatively comprehensive coverage of toxic substances in food, air, and water with brevity, thereby continuing to serve as an updated introductory text for toxicology students and for those involved in allied sciences that require a background in toxicology. The new edition, which now becomes an edited work with contributions from experts around the globe, features four new chapters and a number of existing chapters that have been updated and expanded, notably those on mechanisms of toxic effects, conventional toxicity studies, the cardiovascular system, and risk assessment and regulatory toxicology.
The book consists of four parts (Part I–Part IV) that provide guidance on principles of toxicology and testing procedures for toxicities as well as a concise, yet detailed, mechanism of both target organ and nontarget organ toxicities. The book is rounded off with a final section (Part IV) on the toxic effects of chemicals and risk assessment, giving toxicologists, both students and practicing professionals, the necessary tools to enhance their practice. This edition includes new chapters on Clinical Toxicology, Systems Toxicology, Chemicals and Children, and Toxicology of Reproductive Systems, providing the essentials of these topics in the same style as the other chapters in the book. With separate subject and chemical indexes, this is a useful, quick shelf reference for everyone working in toxicology today.
PART I: General Principles of Toxicology. History of Toxicology. Absorption, Distribution, and Excretion of Toxicants. Metabolism of Toxicants. Toxic Effects (Mechanisms of Toxic Effects). Modifying Factors of Toxic Effects. Conventional Toxicity Studies. Systems Toxicology. PART II: Testing Procedures for Nontarget Organ Toxicities. Carcinogenesis. Mutagenesis. Developmental Toxicology. Lactation. PART III: Target Organs and Systems. Toxicology of the Liver. Toxicology of the Kidney. Toxicology of the Immune System. Respiratory System Inhalation Toxicology. Toxicology of the Skin. Toxicology of the Eye. Toxicology of the Nervous System. Cardiovascular System. Toxicology of Reproductive Systems. Toxicology of the Endocrine System. PART IV: Toxic Substances and Risk Assessment. Food Additives and Contaminants. Toxicity of Pesticides. Nanotoxicology. Toxicity of Metals. Environmental Pollutants. Occupational Toxicology. Chemicals and Children. Clinical Toxicology. Risk Assessment and Regulatory Toxicology.